The Effect of High-Dose Vitamin D Supplementation on Calciotropic Hormones and Bone Mineral Density in Obese Subjects with Low Levels of Circulating 25-Hydroxyvitamin D: Results from a Randomized Controlled Study

Purpose: To investigate the effect of weekly single high dose vitamin D supplementation on serum 25-hydroxyvitamin D [25(OH)D], and non-specific musculoskeletal pain in female nurses. Methods: In this prospective study in Kashan/Iran, from April 1, 2014, through September 30, 2014, the 150 nurses with vitamin D deficiency received the weekly pearls of 50,000 units of vitamin D3 for 10 weeks. The serum level of 25(OH)D was measured before and after supplement therapy. The subjects were also asked to complete the Extended Nordic Musculoskeletal Questionnaire. All analyses were conducted with SPSS version 16. Results: After 10 weeks of intervention there was [Formula: see text][Formula: see text]ng/mL increase in 25(OH)D. The 82 nurses (54.7%) had 25(OH)D in normal range, while the 68 nurses (45.3%) were still vitamin D deficient. Weight could explain 15.4% increase in 25(OH)D. Before intervention 135 (90%), of nurses reported musculoskeletal pain in at least one region, after intervention this number decreased to 72.7%. There was a statistically significant improvement in musculoskeletal pain in neck, shoulders, upper back, lower back, hips/tights, knees, and ankles/feet after intervention. Conclusions: The weekly single high dose of vitamin D for 10 weeks could resolve vitamin D deficiency in about half of the patients. Patients with non-specific musculoskeletal pain might benefit from vitamin D supplementation.

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Impact of high-dose vitamin D 3 on plasma free 25-hydroxyvitamin D concentrations and antimicrobial peptides in critically ill mechanically ventilated adults

Nutrition ◽

10.1016/j.nut.2017.02.002 ◽

2017 ◽

Vol 38 ◽

pp. 102-108 ◽

Cited By ~ 11

Author(s):

Jenny E. Han ◽

Jessica A. Alvarez ◽

Jennifer L. Jones ◽

Vin Tangpricha ◽

Mona A. Brown ◽

...

Keyword(s):

Vitamin D ◽

Antimicrobial Peptides ◽

Critically Ill ◽

High Dose ◽

Mechanically Ventilated ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Vitamin D 3 ◽

High Dose Vitamin

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Effect of vitamin D supplement on depression scores in people with low levels of serum 25-hydroxyvitamin D: nested case—control study and randomised clinical trial

The British Journal of Psychiatry ◽

10.1192/bjp.bp.111.104349 ◽

2012 ◽

Vol 201 (5) ◽

pp. 360-368 ◽

Cited By ~ 108

Author(s):

Marie Kjærgaard ◽

Knut Waterloo ◽

Catharina E. A. Wang ◽

Bjørg Almås ◽

Yngve Figenschau ◽

...

Keyword(s):

Vitamin D ◽

Depressive Symptoms ◽

Rating Scale ◽

Seasonal Pattern ◽

Depression Scale ◽

High Serum ◽

High Dose ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Low Levels

AimsTo compare depressive symptoms in participants with low and high serum 25-hydroxyvitamin D (25(OH)D) levels and to examine whether supplementation with vitamin D3 would improve symptoms in those with low serum 25(OH)D levels.MethodParticipants with low 25(OH)D levels were randomised to either placebo or 40 000 IU vitamin D3 per week for 6 months. Individuals with high serum 25(OH)D levels were used as nested controls. Depressive symptoms were evaluated with the Beck Depression Inventory, Hospital Anxiety and Depression Scale, Seasonal Pattern Assessment Scale and Montgomery-Åsberg Depression Rating Scale. The study was registered at ClinicalTrials.gov (NCT00960232).ResultsParticipants with low 25(OH)D levels (n=230) at baseline were more depressed (P<0.05) than participants with high 25(OH)D levels (n=114). In the intervention study no significant effect of high-dose vitamin D was found on depressive symptom scores when compared with placebo.ConclusionsLow levels of serum 25(OH)D are associated with depressive symptoms, but no effect was found with vitamin D supplementation.

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Effect of High‐Dose Vitamin D Supplementation on Bone Density in Youth with Osteogenesis Imperfecta: A Randomized Controlled Trial

The FASEB Journal ◽

10.1096/fasebj.29.1_supplement.758.9 ◽

2015 ◽

Vol 29 (S1) ◽

Author(s):

Laura Plante ◽

Louis‐Nicolas Veilleux ◽

Hope Weiler ◽

Frank Rauch

Keyword(s):

Vitamin D ◽

Randomized Controlled Trial ◽

Bone Density ◽

Osteogenesis Imperfecta ◽

Controlled Trial ◽

Vitamin D Supplementation ◽

High Dose ◽

Randomized Controlled ◽

High Dose Vitamin

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Are Indian obese children and adolescents at increased risk for Vitamin D deficiency?

Indian Journal of Medical Sciences ◽

10.25259/ijms_510_2020 ◽

2021 ◽

Vol 0 ◽

pp. 1-5

Author(s):

Aashima Dabas ◽

T. Aravind ◽

Sangeeta Yadav ◽

Mukta Mantan ◽

Smita Kaushik

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D Supplementation ◽

Obese Children ◽

Indian Children ◽

Hydroxyvitamin D ◽

Increased Risk ◽

High Risk Factor ◽

25 Hydroxyvitamin D ◽

Obese Subjects

Objectives: Obesity has been mentioned as a high risk factor for Vitamin D deficiency (VDD) requiring supplementation in Indian children. Material and Methods: Forty obese and age-matched non-obese subjects (age 5–18 years) were assessed for lifestyle parameters, metabolic profile, and serum 25-hydroxyvitamin D (25OHD). VDD was defined as serum 25OHD < 12 ng/mL. Results: Mean 25OHD was comparable among obese and controls (15.0 ± 9.95 and 15.1 ± 4.79 ng/mL; P = 0.97) with VDD seen in 82% of cases and 85% of controls. Pubertal cases had lower 25OHD values than prepubertal obese cases (10.78 ± 4.69 and 17.2 ± 11 ng/mL; P = 0.06). Mean duration of physical activity (<2 h/week) and screen time (>2 h/day) was similar across prepubertal and pubertal groups and between obese and controls. Obesity was not associated with risk for VDD among cases and controls (odds ratio 0.83, 95% C.I. 0.25–2.7, P = 0.76). Conclusion: Obese pubertal subjects were more at risk for VDD than prepubertal subjects. Routine Vitamin D supplementation to obese Indian children may be considered during adolescence.

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