Parathyroid Hormone versus Phorbol Ester Stimulation of Activator Protein-1 Gene Family Members in Rat Osteosarcoma Cells

1997 ◽  
Vol 61 (1) ◽  
pp. 52-58 ◽  
Author(s):  
R. C. Koe ◽  
J. C. Clohisy ◽  
D. R. Tyson ◽  
M. R. Pulumati ◽  
T. F. Cook ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Gene Family ◽  
Phorbol Ester ◽  
Family Members ◽  
Activator Protein 1 ◽  
Osteosarcoma Cells ◽  
Activator Protein ◽  
Stimulation Of

Activator protein-1 is necessary for angiotensin-II stimulation of human adrenocorticotropin receptor gene transcription

2001 ◽  
Vol 268 (6) ◽  
pp. 1802-1810
Author(s):  
Danielle Naville ◽  
Estelle Bordet ◽  
Marie-Claude Berthelon ◽  
Philippe Durand ◽  
Martine Begeot
Keyword(s):  
Angiotensin Ii ◽  
Gene Transcription ◽  
Receptor Gene ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Stimulation Of

Activator Protein-1 Inhibition by 3-[(Dodecylthiocarbonyl)Methyl]-Glutamaride Impairs Invasion and Radiosensitizes Osteosarcoma Cells In Vitro

2013 ◽  
Vol 28 (4) ◽  
pp. 351-358
Author(s):  
María Sol Brassesco ◽  
Julia Alejandra Pezuk ◽  
Jaqueline Carvalho de Oliveira ◽  
Elvis Terci Valera ◽  
Harley Francisco de Oliveira ◽  
...  
Keyword(s):  
Activator Protein 1 ◽  
Osteosarcoma Cells ◽  
Activator Protein

Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms

2016 ◽  
Vol 17 (3) ◽  
pp. 291-304 ◽  
Author(s):  
Alexandra Papoudou-Bai ◽  
Eleftheria Hatzimichael ◽  
Alexandra Barbouti ◽  
Panagiotis Kanavaros
Keyword(s):  
Expression Patterns ◽  
Family Members ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Lymphoid Neoplasms

scholarly journals Expression of activator protein-1 (AP-1) family members in breast cancer

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Amirhossein Kharman-Biz ◽  
Hui Gao ◽  
Reza Ghiasvand ◽  
Chunyan Zhao ◽  
Kazem Zendehdel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family Members ◽  
Activator Protein 1 ◽  
Activator Protein

scholarly journals Differential Activation of the Connexin 43 Promoter by Dimers of Activator Protein-1 Transcription Factors in Myometrial Cells

Endocrinology ◽  
2005 ◽  
Vol 146 (4) ◽  
pp. 2048-2054 ◽  
Author(s):  
Jennifer A. Mitchell ◽  
Stephen J. Lye
Keyword(s):  
Transcription Factors ◽  
Connexin 43 ◽  
Family Members ◽  
Expression Vectors ◽  
Central Component ◽  
Activator Protein 1 ◽  
Cx43 Expression ◽  
Myometrial Cells ◽  
Activator Protein ◽  
Expression Of Genes

Abstract The expression of activator protein-1 (AP-1) transcription factors is increased in the myometrium at term and may therefore regulate the expression of genes, such as connexin 43 (Cx43), required for the onset of labor. The region upstream of the mouse, rat, and human Cx43 genes contains two consensus AP-1 binding sequences, a proximal AP-1, located close to the TATA box, and a distal AP-1, 1 kb upstream. A transient transfection system was developed in which Syrian hamster myometrial cells were transfected with Cx43 promoter-luciferase constructs in combination with expression vectors for the AP-1 family. Transfection with c-Jun or JunB had no effect on transcription from the Cx43 promoter, whereas transfection with JunD or combinations of Jun and Fos family members led to significant increases in transcription. Deletion of the distal AP-1 site did not abrogate transcription driven by Fos/Jun, whereas a 2-bp mutation in the proximal AP-1 site significantly reduced pCx43 transactivation by AP-1 dimers. Dimers comprising Fos/Jun proteins conferred greater transcriptional activity than Jun dimmers, with Fra-2/JunB combination conferring greatest activity. These data suggest that increased expression of Fos family members in the myometrium at term drives the increase in Cx43 transcription and expression during labor. Because expression of Fra-2 increases earlier than other Fos family members and confers the highest transcriptional drive to the Cx43 promoter, our data suggest that Fra-2 is a central component in the regulation of Cx43 expression during labor.

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