Age effects on cortical thickness in young Down’s syndrome subjects: a cross-sectional gender study

2015 ◽  
Vol 57 (4) ◽  
pp. 401-411 ◽  
Author(s):  
Andrea Romano ◽  
Marta Moraschi ◽  
Riccardo Cornia ◽  
Alessandro Bozzao ◽  
Olga Gagliardo ◽  
...  
Keyword(s):  
Cortical Thickness ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Age Effects ◽  
Cross Sectional ◽  
Gender Study

Atrioventricular septal defect with tetralogy of Fallot

1991 ◽  
Vol 1 (4) ◽  
pp. 396-398
Author(s):  
Bharat Dalvi ◽  
Krishnagopal Gupta ◽  
Satyavan Sharma
Keyword(s):  
Tetralogy Of Fallot ◽  
Septal Defect ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Atrioventricular Septal Defect ◽  
Cross Sectional

SummaryWe present a case of atrioventricular septal defect associated with tetralogy of Fallot which was diagnosed by cross-sectional echocardiography and angiography. The diagnosis was confirmed at necropsy. This case is unusual for the absence of Down's syndrome. We discuss the role of clinical, echocardiographic, hemodynamic and angiographic studies.

Age-Related Cortical Thickness Reduction in Non-Demented Down's Syndrome Subjects

2015 ◽  
Vol 26 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Andrea Romano ◽  
Riccardo Cornia ◽  
Marta Moraschi ◽  
Alessandro Bozzao ◽  
Laura Chiacchiararelli ◽  
...  
Keyword(s):  
Cortical Thickness ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Thickness Reduction ◽  
Age Related

scholarly journals Age-related decrements in cortical gyrification: Evidence from an accelerated longitudinal dataset

2020 ◽  
Author(s):  
Christopher R. Madan
Keyword(s):  
Cortical Thickness ◽  
Healthy Adults ◽  
Age Effects ◽  
Age Changes ◽  
Cross Sectional ◽  
Age Related ◽  
Sulcal Morphology ◽  
Longitudinal Dataset

AbstractCortical gyrification has been found to decrease due to aging, but thus far this has only been examined in cross-sectional samples. Interestingly, the topography of these age-related differences in gyrification follow a distinct gradient along the cortex relative to age effects on cortical thickness, likely suggesting a different underlying neurobiological mechanism. Here I examined several aspects of gyrification in an accelerated longitudinal dataset of 280 healthy adults aged 45-92 with an interval between first and last MRI session of up to 10 years (total of 815 MRI sessions). Results suggest that age changes in sulcal morphology underlie these changes in gyrification.

Incidence of Celiac Disease in Children with Down’s Syndrome

2021 ◽  
Vol 15 (10) ◽  
pp. 2582-2583
Author(s):  
Sana Pervez ◽  
Syed Sajid Munir ◽  
Maimoona Saeed
Keyword(s):  
Down Syndrome ◽  
Celiac Disease ◽  
Biopsy Specimen ◽  
Venous Blood ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Keywords Celiac Disease

Aim: Incidence of celiac disease among children with down’s syndrome Setting: Pediatrics department, Khyber Teaching Hospital, Peshawar Study design: Cross sectional study Study duration: 20/7/2019 to 20/1/2020 Methodology: A total of 241 subjects were selected. Five ml of venous blood was obtained from all patients to detect the Anti-tTG Ab. Among those patients who are positive for the antibody, endoscopy and biopsy specimen from duodenum were sent to hospital laboratory to confirm the presence of villus atrophy. Results: Mean age was 8 ± 4.57. 44% children were male and 56% children were female. More over 4% children had celiac disease and 96% children didn’t have celiac disease. Conclusion: The frequency of celiac disease was 4% among children presenting with Down syndrome. Keywords: Celiac disease, Down’s syndrome.

scholarly journals Cholelithiasis and biliary sludge in Down’s syndrome patients

2007 ◽  
Vol 125 (6) ◽  
pp. 329-332 ◽  
Author(s):  
Márcia Cristina Bastos Boëchat ◽  
Kátia Silveira da Silva ◽  
Juan Clinton Llerena Jr ◽  
Paulo Roberto Mafra Boëchat
Keyword(s):  
Ultrasound Examination ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Gallstone Formation ◽  
Abdominal Ultrasound ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Brazilian Literature ◽  
Biliary Sludge ◽  
Abdominal Ultrasound Examination

CONTEXT AND OBJECTIVE: Although studies have demonstrated increased frequency of gallbladder abnormalities among Down’s syndrome (DS) patients in some countries, there is only one paper on this subject in the Brazilian literature. The aim of this study was to demonstrate the prevalence, clinical characteristics and evolution of lithiasis and biliary sludge among DS patients in a maternity and children’s hospital in Rio de Janeiro. DESIGN AND SETTING: This was a cross-sectional study followed by a retrospective cohort study on all individuals with an ultrasound diagnosis of gallbladder abnormalities. METHODS: 547 DS patients (53.2% male, 46.8% female) attending the Instituto Fernandes Figueira in 2001 underwent abdominal ultrasound examination at ages of between one day and three years (mean: five months). Clinical and ultrasound data were analyzed. RESULTS: In 50 patients (9.1%), the ultrasound demonstrated gallbladder abnormalities (6.9% lithiasis and 2.1% biliary sludge). Spontaneous resolution was observed in 66.7% of the patients with biliary sludge and 28.9% with lithiasis. Cholecystectomy was carried out on 26.3% of the patients with gallstones. CONCLUSION: The results from this study and comparison with the literature suggest that DS patients are at risk of developing lithiasis and biliary sludge and should be monitored throughout the neonatal period, even if there are no known risk factors for gallstone formation. Most frequently, these gallbladder abnormalities occur without symptoms and spontaneously resolve in most non-symptomatic patients. DS patients should be monitored with serial abdominal ultrasound, and cholecystectomy is indicated for symptomatic cases or when cholecystitis is present.

scholarly journals Parental consanguinity and congenital heart defects in Afghan children with Down’s syndrome

2021 ◽  
Vol 61 (6) ◽  
pp. 306-10
Author(s):  
Abdul Muhib Sharifi ◽  
S. Najmuddin Jalal ◽  
M. Sharif Sediqi ◽  
M. Akbar Ibrahimi ◽  
A. Wali Sharifi
Keyword(s):  
Congenital Heart ◽  
Septal Defect ◽  
Heart Defects ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Marriage Rate ◽  
Cross Sectional Study ◽  
Consanguineous Marriage ◽  
Cross Sectional ◽  
Low Prevalence

Abstract Background: It seems that parents’ consanguinity status effects the pattern of congenital heart defects (CHDs). In this study the CHD pattern in children with Down’s syndrome (DS) was determined in Afghanistan’s children population with a high consanguineous marriage rate and compared with historical cohorts from populations with low prevalence of parental consanguinity. Objective: This analytic cross sectional study aimed to determine the frequency and distribution of CHDs in Afghanistan children with Down’s Syndrome as a group in a community with a high consanguineous marriage rate and comparing these with different global studies and populations with low prevalence of consanguinity. Methods: This analytic cross sectional study was conducted in a pediatric teaching hospital in Kabul city - Afghanistan, named Maiwand Hospital. The subjects were all children with DS proven by clinical and cytogenetic study and referred to the pediatric cardiology service from September 2018–September 2020. Parents’ consanguinity was documented and 2D echocardiography and Doppler studies were performed by two experienced pediatric cardiologists after physical examination, ECG, and chest X-ray for each patient. Results: During the two-year study period, 120 DS patients were identified, 78 (65%) of whom had CHDs. The prevalence of isolated and multiple CHD in the 78 children with DS were 35% (42 patients) and 30% (36 patients), respectively. Ventricular septal defect (20.5%) and atrial septal defect (15.3%) were the most common isolated defects. The combination of VSD and PDA (20.5%) were the most frequent multiple CHDs. The most com­mon associations of CHD were VSD + PDA (20.5%) and VSD + ASD (10.2%). Consanguinity was found in 69.2 % of all parents. Conclusions: A higher frequency of CHD was documented in DS children from this population with a high consanguineous marriage rate. The frequencies of specific lesions were almost similar to those reported locally and internationally; VSD was the most frequently detected in this study. Interesting was the predominance of left-right shunt lesions and the relative rarity of cyanotic and complex CHD in this DS population. key words: congenital heart disease, atrioventricular septal defect, Down’s syndrome, trisomy 21, Afghanistan

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