A single center’s experience in pediatric cystine stone disease management: what changed over time?

Urolithiasis ◽  
2020 ◽  
Vol 48 (6) ◽  
pp. 493-499
Author(s):  
Tariq Asi ◽  
Hasan Serkan Dogan ◽  
Ali Cansu Bozaci ◽  
Burak Citamak ◽  
Mesut Altan ◽  
...  
2018 ◽  
Vol 56 (1) ◽  
pp. 269-288 ◽  
Author(s):  
Amy O. Charkowski

Bacterial soft rot is a disease complex caused by multiple genera of gram-negative and gram-positive bacteria, with Dickeya and Pectobacterium being the most widely studied soft-rot bacterial pathogens. In addition to soft rot, these bacteria also cause blackleg of potato, foot rot of rice, and bleeding canker of pear. Multiple Dickeya and Pectobacterium species cause the same symptoms on potato, complicating epidemiology and disease resistance studies. The primary pathogen species present in potato-growing regions differs over time and space, further complicating disease management. Genomics technologies are providing new management possibilities, including improved detection and biocontrol methods that may finally allow effective disease management. The recent development of inbred diploid potato lines is also having a major impact on studying soft-rot pathogens because it is now possible to study soft-rot disease in model plant species that produce starchy vegetative storage organs. Together, these new discoveries have changed how we face diseases caused by these pathogens.


2019 ◽  
Author(s):  
Eline Meijer ◽  
Annelies E. van Eeden ◽  
Annemarije L. Kruis ◽  
Melinde R.S. Boland ◽  
W. J.J. (Pim) Assendelft ◽  
...  

Abstract Background: The cluster randomized controlled trial on (cost-)effectiveness of integrated chronic obstructive pulmonary disease (COPD) management in primary care (RECODE) showed that integrated disease management (IDM) in primary care had no effect on quality of life (QOL) in COPD patients compared with usual care. It is possible that only a subset of COPD patients in primary care benefit from IDM. We therefore examined which patients benefit from IDM, and whether patient characteristics predict clinical improvement over time. Method: Post-hoc analyses of the RECODE trial among 1086 COPD patients. Logistic regression analyses were performed with baseline characteristics as predictors to examine determinants of improvement in QOL, defined as a minimal decline in Clinical COPD Questionnaire (CCQ) of 0.4 points after 12 and 24 months of IDM. We also performed moderation analyses to examine whether predictors of clinical improvement differed between IDM and usual care. Results: Regardless of treatment type, more severe dyspnea (MRC) was the most important predictor of clinically improved QOL at 12 and 24 months, suggesting that these patients have most room for improvement. Although the interaction effect between gender and treatment condition was nonsignificant, it appeared that male patients were worse off with IDM than usual care. Conclusions: More severe dyspnea is a key predictor of improved QOL in COPD patients over time. Future IDM programs, provided that they are effective, may benefit from tailoring to gender such that the programs meet the individual needs of both female and male COPD patients. Trial registration: Netherlands Trial Register, NTR2268. Registered 31 March 2010, https://www.trialregister.nl/trial/2144 .


2021 ◽  
Vol 13 (11) ◽  
pp. 11
Author(s):  
Esther Gloria Mbabazi ◽  
Enoch M. Kikulwe ◽  
Joseph Lule Kyanjo ◽  
Nasser Mulumba ◽  
Edward Kato ◽  
...  

The livelihoods of millions of banana-farming households have been affected by Banana Xanthomonas Wilt (BXW) in Uganda for nearly two decades. The disease has no known cure, all banana cultivars grown are susceptible to it and it is endemic in all banana-producing regions in the country. This study analysed the long-term impact of the disease on the livelihoods of banana-producing households. Using a balanced panel dataset of 1,056 households, which were visited in 2015 and revisited in 2018, provides the opportunity to empirically measure the long-term consequences of the disease on farmers’ economic wellbeing in the four major banana growing regions in Uganda. We find striking results pertinent to disease incidence, success in disease management, household income and poverty when deploying BXW control practices. Although the disease has remained present in farmers’ fields, there is a significant reduction in household poverty levels. Results show that some farmers expanded the production of beans and coffee without encroaching on their banana plantations. Increase in bean production was largely through intercropping. Investment in coffee was constrained by land ownership, hence only a viable venture for the wealthy farmers who own bigger pieces of land. Land-poor farmers continued to rely on bananas for their livelihoods. Consistent participation in disease management training significantly influenced adoption of the cultural control practices. Consequently, farming households that systematically adopted these practices were able to maintain low levels of disease incidence, improve productivity by 438 kg/ha/year and increased their daily and annual household income by US$1.75 and UGX 2.383 million (US$648), respectively. The findings suggest that banana is an important crop to smallholder farmers and expansion into other cash crops requires bigger resource outlays, and that despite continued exposure to BXW, farmers’ income increased over time. Farmers should continuously and systematically use the recommended control practices to avoid BXW resurgence and, consequently, a reduction in their income.


2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Manint Usawachintachit ◽  
Matthew Hudnall ◽  
Alexander Rifkind ◽  
David Tzou ◽  
Ryan Hsi ◽  
...  

Plant Disease ◽  
2004 ◽  
Vol 88 (6) ◽  
pp. 657-661 ◽  
Author(s):  
D. S. Mueller ◽  
S. N. Jeffers ◽  
J. W. Buck

Integrated disease management should provide the most effective means of controlling rusts on ornamental crops over time, and fungicides are an important component of an integrated rust management program. Proper timing of fungicide applications is critical for effective disease management; however, information about application timing is lacking for rusts on ornamental crops. The objective of this study was to determine how fungicides affected rust development on daylily, geranium, and sunflower plants when applied several days before or after inoculation. Five fungicides registered for use against rusts on ornamental crops were evaluated: the strobilurin azoxystrobin; three sterol biosynthesis inhibiting fungicides—myclobutanil, propiconazole, and triadimefon; and the broad spectrum protectant chlorothalonil. All five fungicides significantly reduced lesion development by rust pathogens on daylily, geranium, and sunflower plants when these compounds were applied preventatively up to 15 days before inoculation and infection with a few exceptions (e.g., propiconazole on geranium and triadimefon on sunflower). Curative activity, which resulted from fungicide application after inoculation, was observed for the three rusts with some products (azoxystrobin on all three plants and myclobutanil, propiconazole, and triadimefon on geranium) when applied up to 7 days postinoculation. In general, fungicide efficacy with several of the products decreased as the time from application to inoculation (preventative activity) or inoculation to application (curative activity) increased.


2018 ◽  
Vol 32 (2) ◽  
pp. 148-153 ◽  
Author(s):  
Manint Usawachintachit ◽  
Benjamin Sherer ◽  
Matthew Hudnall ◽  
David T. Tzou ◽  
Kazumi Taguchi ◽  
...  

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