scholarly journals Novel genetic risk factors for asthma in African American children: Precision Medicine and the SAGE II Study

2016 ◽  
Vol 68 (6-7) ◽  
pp. 391-400 ◽  
Author(s):  
Marquitta J. White ◽  
O. Risse-Adams ◽  
P. Goddard ◽  
M. G. Contreras ◽  
J. Adams ◽  
...  
Keyword(s):  
Risk Factors ◽  
African American ◽  
Precision Medicine ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
African American Children ◽  
American Children

scholarly journals Novel Genetic Risk factors for Asthma in African American Children: Precision Medicine and The SAGE II Study

2016 ◽  
Author(s):  
MJ White ◽  
O Risse-Adams ◽  
P Goddard ◽  
MG Contreras ◽  
J Adams ◽  
...  
Keyword(s):  
Risk Factors ◽  
African American ◽  
Genetic Risk ◽  
Ethnic Disparities ◽  
Genetic Risk Factors ◽  
Asthma Prevalence ◽  
African American Children ◽  
Inflammatory Disorder ◽  
Common Chronic Disease ◽  
American Children

AbstractBackgroundAsthma, an inflammatory disorder of the airways, is the most common chronic disease of children worldwide. There are significant racial/ethnic disparities in asthma prevalence, morbidity and mortality among U.S. children. This trend is mirrored in obesity, which may share genetic and environmental risk factors with asthma. The majority of asthma biomedical research has been performed in populations of European decent.ObjectiveWe sought to identify genetic risk factors for asthma in African American children. We also assessed the generalizability of genetic variants associated with asthma in European and Asian populations to African American children.MethodsOur study population consisted of 1227 (812 asthma cases, 415 controls) African American children with genome-wide single nucleotide polymorphism (SNP) data. Logistic regression was used to identify associations between SNP genotype and asthma status.ResultsWe identified a novel variant in the PTCHD3 gene that is significantly associated with asthma (rs660498, p = 2.2 x10−7) independent of obesity status. Approximately 5% of previously reported asthma genetic associations identified in European populations replicated in African Americans.ConclusionsOur identification of novel variants associated with asthma in African American children, coupled with our inability to replicate the majority of findings reported in European Americans, underscores the necessity for including diverse populations in biomedical studies of asthma.

scholarly journals Carbohydrate intake and cardiometabolic risk factors in high BMI African American children

2010 ◽  
Vol 7 (1) ◽  
pp. 10 ◽  
Author(s):  
Sushma Sharma ◽  
Lindsay S Roberts ◽  
Robert H Lustig ◽  
Sharon E Fleming
Keyword(s):  
Risk Factors ◽  
African American ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Carbohydrate Intake ◽  
African American Children ◽  
American Children ◽  
High Bmi

scholarly journals Sugar intake and cardio metabolic risk factors in high BMI African American children

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Sushma Sharma ◽  
Lindsay S Roberts ◽  
Mark L Hudes ◽  
Robert H Lustig ◽  
Sharon E Fleming
Keyword(s):  
Risk Factors ◽  
African American ◽  
Metabolic Risk Factors ◽  
African American Children ◽  
Metabolic Risk ◽  
Sugar Intake ◽  
American Children ◽  
High Bmi
Sign in / Sign up

Export Citation Format

Share Document