Family Processes as Resources for African American Children Exposed to a Constellation of Sociodemographic Risk Factors

2000 ◽  
Vol 29 (1) ◽  
pp. 53-65 ◽  
Author(s):  
Karla Klein ◽  
Rex Forehand
2016 ◽  
Vol 68 (6-7) ◽  
pp. 391-400 ◽  
Author(s):  
Marquitta J. White ◽  
O. Risse-Adams ◽  
P. Goddard ◽  
M. G. Contreras ◽  
J. Adams ◽  
...  

2016 ◽  
Author(s):  
MJ White ◽  
O Risse-Adams ◽  
P Goddard ◽  
MG Contreras ◽  
J Adams ◽  
...  

AbstractBackgroundAsthma, an inflammatory disorder of the airways, is the most common chronic disease of children worldwide. There are significant racial/ethnic disparities in asthma prevalence, morbidity and mortality among U.S. children. This trend is mirrored in obesity, which may share genetic and environmental risk factors with asthma. The majority of asthma biomedical research has been performed in populations of European decent.ObjectiveWe sought to identify genetic risk factors for asthma in African American children. We also assessed the generalizability of genetic variants associated with asthma in European and Asian populations to African American children.MethodsOur study population consisted of 1227 (812 asthma cases, 415 controls) African American children with genome-wide single nucleotide polymorphism (SNP) data. Logistic regression was used to identify associations between SNP genotype and asthma status.ResultsWe identified a novel variant in the PTCHD3 gene that is significantly associated with asthma (rs660498, p = 2.2 x10−7) independent of obesity status. Approximately 5% of previously reported asthma genetic associations identified in European populations replicated in African Americans.ConclusionsOur identification of novel variants associated with asthma in African American children, coupled with our inability to replicate the majority of findings reported in European Americans, underscores the necessity for including diverse populations in biomedical studies of asthma.


2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Sushma Sharma ◽  
Lindsay S Roberts ◽  
Mark L Hudes ◽  
Robert H Lustig ◽  
Sharon E Fleming

2020 ◽  
Vol 5 (3) ◽  
pp. p129
Author(s):  
Shervin Assari

Background: Positive urgency reflects a specific facet of impulsivity and correlates with several health-related risk behaviors such as obesity, food addiction, and substance use. However, less is known about whether positive urgency is similarly or differently associated with high body mass index (BMI) across diverse racial groups. Aim: The aim of this study was to investigate racial differences in the associations between positive urgency and BMI in 9-10-year-old children in the US. Materials and Methods: This cross-sectional study used the Adolescent Brain Cognitive Development (ABCD) study. Participants were 11590 American children between ages 9 and 10 years old. The independent variable was positive urgency measured by the Urgency, Premeditation (lack of), Perseverance (lack of), Sensation Seeking, Positive Urgency, Impulsive Behavior Scale (UPPS-SS). The primary outcome was BMI. Race was the moderator. Demographic variables (age and sex) were covariates. Mixed-effects regression models were used for data analysis to adjust for the nested nature of the ABCD data. We also used weights (propensity score) to generate nationally representative results. Results: In the pooled sample, race showed a statistically significant interaction with positive urgency on children’s BMI, indicating a stronger effect of positive urgency on BMI for White children, compared to African American children. Conclusion: The association between positive urgency and BMI seems to be weaker in African American children than in White American children. The role of individual-level risk factors such as impulsive traits may be smaller for African American than White American children. Future research should study the role of obesogenic environments and other area level indicators in altering the effects of individual-level risk factors on BMI and obesity.


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