scholarly journals Vertebral disk morphology of the lumbar spine: a retrospective analysis of collagen-sensitive mapping using dual-energy computed tomography

2020 ◽  
Author(s):  
Friederike Schömig ◽  
Matthias Pumberger ◽  
Yannick Palmowski ◽  
Ann-Kathrin Ditges ◽  
Torsten Diekhoff ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lumbar Spine ◽  
Diagnostic Accuracy ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Dual Energy ◽  
Interrater Agreement ◽  
Dual Energy Computed Tomography ◽  
Disk Displacement ◽  
Disk Pathology

Abstract Objectives To investigate the diagnostic accuracy of collagen-sensitive maps derived from dual-energy computed tomography (DECT) for the detection of lumbar disk pathologies in a feasibility setting. Materials and methods We retrospectively reviewed magnetic resonance imaging (MRI), computed tomography (CT), and DECT datasets acquired in patients who underwent periradicular therapy of the lumbar spine from June to December 2019. Three readers scored DECT collagen maps, conventional CT, and MRI for presence, type, and extent of disk pathology. Contingency table analyses were performed to determine diagnostic accuracy using MRI as standard of reference. Interrater agreement within and between imaging modalities was evaluated by computing intraclass correlation coefficients (ICCs) and Cohen’s kappa. Correlation between sum scores of anteroposterior disk displacement was determined by calculation of a paired t test. Results In 21 disks in 13 patients, DECT had a sensitivity of 0.87 (0.60–0.98) and specificity of 1.00 (0.54–1.00) for the detection of disk pathology. Intermodality agreement for anteroposterior disk displacement was excellent for DECT (ICC 0.963 [0.909–0.985]) and superior to CT (ICC 0.876 [0.691–0.95]). For anteroposterior disk displacement, DECT also showed greater within-modality interrater agreement (ICC 0.820 [0.666–0.916]) compared with CT (ICC 0.624 [0.39–0.808]). Conclusion Our data suggest that collagen-sensitive imaging has an added benefit, allowing more accurate evaluation of the extent of disk displacement with higher interrater reliability. Thus, DECT could provide useful diagnostic information in patients undergoing CT for other indications or with contraindications to MRI.

scholarly journals Distribution of bony erosions in feet and performance of two bone erosion scores: A dual-energy computed tomography study of 61 patients with gout

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259194
Author(s):  
Amandine Chabernaud Negrier ◽  
Lokmane Taihi ◽  
Eric Vicaut ◽  
Pascal Richette ◽  
Thomas Bardin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Erosion ◽  
Intraclass Correlation ◽  
Metatarsophalangeal Joint ◽  
Dual Energy ◽  
Radiology Department ◽  
Crystal Deposition ◽  
First Metatarsophalangeal Joint ◽  
Dual Energy Computed Tomography ◽  
Bone Erosions

Objectives To assess the distribution of bone erosions and two erosion scores in the feet of patients with gout and analyze the association between erosion scores and monosodium urate (MSU) crystal deposition using dual-energy computed tomography (DECT). Materials and methods We included all patients who underwent DECT of both feet between 2016 and 2019 in our radiology department, with positive detection of MSU deposits. Data on sex, age, treatment, serum urate, and DECT urate volumes were obtained. CT images were analyzed to score bone erosions in 31 sites per foot by using the semi-quantitative method based on the Rheumatoid Arthritis MRI Scoring (RAMRIS) system and the Dalbeth-simplified score. Reproducibility for the two scores was calculated with intraclass correlation coefficients (ICCs). Correlations between clinical features, erosion scores and urate crystal volume were analyzed by the Spearman correlation coefficient (r). Results We studied 61 patients (mean age 62.0 years); 3,751 bones were scored. The first metatarsophalangeal joint and the midfoot were the most involved in terms of frequency and severity of bone erosions. The distribution of bone erosions was not asymmetrical. The intra- and inter-observer reproducibility was similar for the RAMRIS and Dalbeth-simplified scores (ICC 0.93 vs 0.94 and 0.96 vs 0.90). DECT urate volume was significantly correlated with each of the two erosion scores (r = 0.58–0.63, p < 0.001). There was a high correlation between the two scores (r = 0.96, p < 0.001). Conclusions DECT demonstrates that foot erosions are not asymmetric in distribution and predominate at the first ray and midfoot. The two erosion scores are significantly correlated with DECT urate volume. An almost perfect correlation between the RAMRIS and Dalbeth-simplified scores is observed.

Diagnostic accuracy of dual-energy computed tomography (DECT) to differentiate uric acid from non-uric acid calculi: systematic review and meta-analysis

2020 ◽  
Vol 30 (5) ◽  
pp. 2791-2801 ◽  
Author(s):  
Trevor A. McGrath ◽  
Robert A. Frank ◽  
Nicola Schieda ◽  
Brian Blew ◽  
Jean-Paul Salameh ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Systematic Review ◽  
Uric Acid ◽  
Diagnostic Accuracy ◽  
Meta Analysis ◽  
Dual Energy ◽  
Dual Energy Computed Tomography

Diagnostic Accuracy of Dual-Energy CT in Detection of Acute Pulmonary Embolism: A Systematic Review and Meta-Analysis

2020 ◽  
pp. 084653712090206 ◽  
Author(s):  
Waleed Abdellatif ◽  
Mahmoud Ahmed Ebada ◽  
Souad Alkanj ◽  
Ahmed Negida ◽  
Nicolas Murray ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Systematic Review ◽  
Pulmonary Embolism ◽  
Diagnostic Accuracy ◽  
Likelihood Ratio ◽  
Acute Pulmonary Embolism ◽  
Meta Analysis ◽  
Dual Energy ◽  
Dual Energy Computed Tomography ◽  
Sensitivity Specificity

Purpose: In this systematic review and meta-analysis, we aimed to investigate the accuracy of dual-energy computed tomography (DECT) in the detection of acute pulmonary embolism (PE). Methods: We searched Medline (via PubMed), EBSCO, Web of Science, Scopus, and the Cochrane Library for relevant published studies. We selected studies assessing the accuracy of DECT in the detection of PE. Quality assessment of bias and applicability was conducted using the Quality of Diagnostic Accuracy Studies-2 tool. Meta-analysis was performed to calculate mean estimates of sensitivity, specificity, positive likelihood ratio (PLR), and negative likelihood ratio (NLR). The summary receiver operating characteristic (sROC) curve was drawn to get the Cochran Q-index and the area under the curve (AUC). Results: Seven studies were included in our systematic review. Of the 182 patients included, 108 patients had PEs. The pooled analysis showed an overall sensitivity and specificity of 88.9% (95% confidence interval [CI]: 81.4%-94.1%) and 94.6% (95% CI: 86.7%-98.5%), respectively. The pooled PLR was 8.186 (95% CI: 3.726-17.986), while the pooled NLR was 0.159 (95% CI: 0.093-0.270). Cochran-Q was 0.8712, and AUC was 0.935 in the sROC curve. Conclusion: Dual-energy computed tomography shows high sensitivity, specificity, and diagnostic accuracy in the detection of acute PE. The high PLR highlights the high clinical importance of DECT as a prevalence-independent, rule-in test. Studies with a larger sample size with standardized reference tests are still needed to increase the statistical power of the study and support these findings.

scholarly journals Disk injury in patients with vertebral fractures—a prospective diagnostic accuracy study using dual-energy computed tomography

2019 ◽  
Vol 29 (8) ◽  
pp. 4495-4502 ◽  
Author(s):  
Matthias Pumberger ◽  
Michael Fuchs ◽  
Nils Engelhard ◽  
Kay Geert Hermann ◽  
Michael Putzier ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Diagnostic Accuracy ◽  
Vertebral Fractures ◽  
Dual Energy ◽  
Diagnostic Accuracy Study ◽  
Dual Energy Computed Tomography ◽  
Accuracy Study

Visualizing patterns of intervertebral disc damage with dual-energy computed tomography: assessment of diagnostic accuracy in an ex vivo spine biophantom

2021 ◽  
pp. 028418512110258
Author(s):  
Julian Pohlan ◽  
Carsten Stelbrink ◽  
Niklas Tuttle ◽  
Felix Kubicka ◽  
Ho Jung Kwon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Intervertebral Disc ◽  
Diagnostic Accuracy ◽  
Ex Vivo ◽  
Dual Energy ◽  
Detection Accuracy ◽  
Single Source ◽  
Ct Scanner ◽  
Dual Energy Computed Tomography ◽  
Diagnostic Potential

Background Previously, dual-energy computed tomography (DECT) has been established for imaging spinal fractures as an alternative modality to magnetic resonance imaging (MRI). Purpose To analyze the diagnostic accuracy of DECT in visualizing intervertebral disc (IVD) damage. Material and Methods The lumbar spine of a Great Dane dog was used as an ex vivo biophantom. DECT was performed as sequential volume technique on a single-source CT scanner. IVDs were imaged before and after an injection of sodium chloride solution and after anterior discectomy in single-source sequential volume DECT technique using 80 and 135 kVp. Chondroitin/Collagen maps (cMaps) were reconstructed at 1 mm and compared with standard CT. Standardized regions of interest (ROI) were placed in the anterior anulus fibrosus, nucleus pulposus, and other sites. Three blinded readers classified all images as intact disc, nucleus lesion, or anulus lesion. Additionally, clinical examples from patients with IVD lesions were retrospectively identified from the radiological database. Results Interrater reliability was almost perfect with a Fleiss kappa of 0.833 (95% confidence interval [CI] 0.83–0.835) for DECT, compared with 0.780 (95% CI 0.778–0.782) for standard CT. For overall detection accuracy of IVD, DECT achieved 91.0% sensitivity (95% CI 83.6–95.8) and 92.0% specificity (95% CI 80.8–97.8). Standard CT showed 91.0% sensitivity (95% CI 83.6–95.8) and 78.0% specificity (95% CI 64.0–88.5). Conclusion DECT reliably identified IVD damage in an ex vivo biophantom. Clinical examples of patients with different lesions illustrate the accurate depiction of IVD microstructure. These data emphasize the diagnostic potential of DECT cMaps.

Identification of bone marrow edema around the ankle joint in non-traumatic patients: Diagnostic accuracy of dual-energy computed tomography

2021 ◽  
Vol 69 ◽  
pp. 341-348
Author(s):  
Giovanni Foti ◽  
Massimo Guerriero ◽  
Niccolò Faccioli ◽  
Alessandro Fighera ◽  
Luigi Romano ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Marrow ◽  
Diagnostic Accuracy ◽  
Ankle Joint ◽  
Bone Marrow Edema ◽  
Dual Energy ◽  
Dual Energy Computed Tomography ◽  
Marrow Edema
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