scholarly journals Clinical translation and implementation of optical imaging agents for precision image-guided cancer surgery

2020 ◽  
Author(s):  
F. B. Achterberg ◽  
M. M. Deken ◽  
R. P. J. Meijer ◽  
J. S. D. Mieog ◽  
J. Burggraaf ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Cancer Surgery ◽  
Clinical Translation ◽  
Imaging Agents ◽  
Image Guided

scholarly journals Tri-functional platform for construction of modular antibody fragments for in vivo18F-PET or NIRF molecular imaging

2020 ◽  
Vol 11 (7) ◽  
pp. 1832-1838
Author(s):  
Raymond F. Gamache ◽  
Kirstin A. Zettlitz ◽  
Wen-Ting K. Tsai ◽  
Jeffrey Collins ◽  
Anna M. Wu ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Optical Imaging ◽  
Targeted Delivery ◽  
Antibody Fragments ◽  
Imaging Agents ◽  
Universal Approach

To provide a universal approach towards the targeted delivery of PET and optical imaging agents, we have developed a tri-functional platform (TFP) for the facile construction of modular, target-specific tracers.

scholarly journals Dual-mode optical imaging system for fluorescence image-guided surgery

2014 ◽  
Vol 39 (13) ◽  
pp. 3830 ◽  
Author(s):  
Nan Zhu ◽  
Suman Mondal ◽  
Shengkui Gao ◽  
Samuel Achilefua ◽  
Viktor Gruev ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Imaging System ◽  
Image Guided Surgery ◽  
Dual Mode ◽  
Fluorescence Image ◽  
Guided Surgery ◽  
Image Guided ◽  
Optical Imaging System

scholarly journals Recommendations for reporting on emerging optical imaging agents to promote clinical approval

Theranostics ◽  
2018 ◽  
Vol 8 (19) ◽  
pp. 5336-5347 ◽  
Author(s):  
Willemieke S. Tummers ◽  
Jason M Warram ◽  
Nynke S. van den Berg ◽  
Sarah E. Miller ◽  
Rutger-Jan Swijnenburg ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Imaging Agents

Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image‐guided oral cancer surgery applications

Head & Neck ◽  
2018 ◽  
Vol 41 (4) ◽  
pp. 1032-1038 ◽  
Author(s):  
Yuxin Wang ◽  
Diya Xie ◽  
Ziyang Wang ◽  
Xudong Zhang ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Indocyanine Green ◽  
Normal Tissue ◽  
Cancer Surgery ◽  
Image Guided ◽  
Tissue Fluorescence ◽  
Kinetics Of

scholarly journals Image-guided in situ detection of bacterial biofilms in a human prosthetic knee infection model: a feasibility study for clinical diagnosis of prosthetic joint infections

2020 ◽  
Author(s):  
Jorrit W. A. Schoenmakers ◽  
Marjolein Heuker ◽  
Marina López-Álvarez ◽  
Wouter B. Nagengast ◽  
Gooitzen M. van Dam ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Bacterial Species ◽  
Bacterial Biofilms ◽  
Infection Model ◽  
Knee Infection ◽  
Prosthetic Knee ◽  
Image Guided ◽  
Prosthetic Joints ◽  
Prosthetic Joint Infections ◽  
Prosthetic Knee Infection

Abstract Purpose Due to an increased human life expectancy, the need to replace arthritic or dysfunctional joints by prosthetics is higher than ever before. Prosthetic joints are unfortunately inherently susceptible to bacterial infection accompanied by biofilm formation. Accurate and rapid diagnosis is vital to increase therapeutic success. Yet, established diagnostic modalities cannot directly detect bacterial biofilms on prostheses. Therefore, the present study was aimed at investigating whether arthroscopic optical imaging can accurately detect bacterial biofilms on prosthetic joints. Methods Here, we applied a conjugate of the antibiotic vancomycin and the near-infrared fluorophore IRDye800CW, in short vanco-800CW, in combination with arthroscopic optical imaging to target and visualize biofilms on infected prostheses. Results We show in a human post-mortem prosthetic knee infection model that a staphylococcal biofilm is accurately detected in real time and distinguished from sterile sections in high resolution. In addition, we demonstrate that biofilms associated with the clinically most relevant bacterial species can be detected using vanco-800CW. Conclusion The presented image-guided arthroscopic approach provides direct visual diagnostic information and facilitates immediate appropriate treatment selection.

scholarly journals Near-infrared emitting lanthanide(iii) complexes as prototypes of optical imaging agents with peptide targeting ability: a methodological approach

RSC Advances ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 1747-1751 ◽  
Author(s):  
Monika Cieslikiewicz-Bouet ◽  
Svetlana V. Eliseeva ◽  
Vincent Aucagne ◽  
Agnès F. Delmas ◽  
Isabelle Gillaizeau ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Azo Dye ◽  
Near Infrared ◽  
Methodological Approach ◽  
Imaging Agents ◽  
Targeting Ability ◽  
Peptide Targeting

NIR Ln(iii) complexes combining a cyclen derivative, azo-dye as a sensitizer and a cRGD peptide as a targeting moiety.

P112: Image guided breast cancer surgery: Intra-Operative Ultrasound (IOUS) vs. Guidewire (GW) placement - A cost analysis

2020 ◽  
Vol 46 (6) ◽  
pp. e40
Author(s):  
Liran Barzilai ◽  
Abdul Syed ◽  
Emma Gray ◽  
Sudhakar Eleti ◽  
Jessica Fairbanks ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cost Analysis ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Image Guided ◽  
Operative Ultrasound

Image-guided surgery using fluorescence: road to clinical translation of novel probes

2016 ◽  
Author(s):  
Pim J. Bongers ◽  
Leonora S. F. Boogerd ◽  
Henricus J. M. Handgraaf ◽  
Charlotte E. S. Hoogstins ◽  
Cornelis J. H. van de Velde ◽  
...  
Keyword(s):  
Clinical Translation ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided

Image-guided near-infrared fluorescent sentinel lymph node mapping in human breast cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e11591-e11591
Author(s):  
S. Troyan ◽  
S. Gibbs-Strauss ◽  
S. Gioux ◽  
R. Oketokoun ◽  
F. Azar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Optical Imaging ◽  
Real Time ◽  
Near Infrared ◽  
Imaging System ◽  
Sulfur Colloid ◽  
Guided Surgery ◽  
Image Guided ◽  
Nir Fluorescence ◽  
Surgical Field

e11591 Background: Breast cancer surgery is presently performed without real-time image-guidance. We have developed a novel optical imaging system for image-guided surgery that uses invisible near-infrared (NIR) fluorescent light to highlight structures on the surgical field with high sensitivity, specificity, and contrast. We have also performed the first human clinical trial of the imaging system in women undergoing SLN mapping for breast cancer. Methods: We used a portable imaging system with an articulating arm that has 6 degrees of freedom, high power LED light source, custom optics, custom software, and sterile drape. The imaging system provided simultaneous and real-time imaging of color video and NIR fluorescence at up to 15 frames per second. N = 6 women with biopsy- confirmed breast cancer undergoing SLN mapping gave informed consent. All subjects received conventional mapping with Tc-99m sulfur colloid using a handheld gamma probe as well as NIR fluorescence-guided SLN mapping using a mixture of indocyanine green (ICG) diluted to a final concentration of 10 μM in human serum albumin (ICG:HSA). Results: The imaging system was easy to position in the operating room, with the articulating arm providing 50” horizontal reach and 70” vertical reach. Working distance to the patient was 18”. NIR fluorescence excitation was 20 mW/cm2 at 760 nm. NIR-depleted white light was 40,000 lux. A total of 1.6 ml of ICG:HSA was injected intra-tumorally and peri-tumorally and the site massaged for 5 min. 8 of 9 SLNs identified by Tc- 99m sulfur colloid were also identified by NIR fluorescence. However, NIR fluorescence identified an SLN, confirmed to have cancer in it, that was not identified by Tc-99m sulfur colloid. These differences were consistent with asynchrony in the injection techniques. Unlike the gamma-ray probe, NIR fluorescence provided high-resolution, large area optical imaging of the surgical field, and helped guide surgical resection. Conclusions: In this 6-patient pilot study, a novel NIR fluorescence optical imaging system was used for the first time, and provided real-time image-guided surgery for SLN mapping of breast cancer. No significant financial relationships to disclose.

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