human immunodeficiency virus envelope
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scholarly journals Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection

2020 ◽  
Vol 7 (10) ◽  
Author(s):  
Hongshuo Song ◽  
Meera Bose ◽  
Suteeraporn Pinyakorn ◽  
Eric Sanders-Buell ◽  
Anne Marie O’Sullivan ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Human Immunodeficiency Virus ◽  
Acute Infection ◽  
Viral Dynamics ◽  
Virus Envelope ◽  
Acute Infections ◽  
Human Immunodeficiency Virus Envelope ◽  
Immunodeficiency Virus ◽  
Host Genetic ◽  
Human Immunodeficiency Virus 1

Abstract We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

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