Epigenetic therapy in combination with a multi-epitope cancer vaccine targeting shared tumor antigens for high-risk myelodysplastic syndrome - a phase I clinical trial

Cancer Immunology Immunotherapy ◽

10.1007/s00262-021-02993-6 ◽

2021 ◽

Author(s):

Staffan Holmberg-Thydén ◽

Inge Høgh Dufva ◽

Anne Ortved Gang ◽

Marie Fredslund Breinholt ◽

Lone Schejbel ◽

...

Keyword(s):

Clinical Trial ◽

High Risk ◽

Myelodysplastic Syndrome ◽

Phase I ◽

Cancer Vaccine ◽

Tumor Antigens ◽

Phase I Clinical Trial ◽

Epigenetic Therapy

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Is the “3+3” Dose-Escalation Phase I Clinical Trial Design Suitable for Therapeutic Cancer Vaccine Development? A Recommendation for Alternative Design

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-13-2671 ◽

2014 ◽

Vol 20 (18) ◽

pp. 4758-4767 ◽

Cited By ~ 25

Author(s):

Osama E. Rahma ◽

Emily Gammoh ◽

Richard M. Simon ◽

Samir N. Khleif

Keyword(s):

Clinical Trial ◽

Phase I ◽

Cancer Vaccine ◽

Dose Escalation ◽

Trial Design ◽

Vaccine Development ◽

Clinical Trial Design ◽

Phase I Clinical Trial ◽

Therapeutic Cancer Vaccine ◽

Alternative Design

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Phase I Clinical Trial of Targeted Marrow Irradiation in Combination with Fludarabine and Busulfan for Conditioning of Hematopoietic Cell Transplant in High Risk Patients

Biology of Blood and Marrow Transplantation ◽

10.1016/j.bbmt.2017.12.375 ◽

2018 ◽

Vol 24 (3) ◽

pp. S321

Author(s):

Paolo Caimi ◽

Naveed Ali ◽

Brenda Cooper ◽

Richard Creger ◽

Ehsan Malek ◽

...

Keyword(s):

Clinical Trial ◽

High Risk ◽

Phase I ◽

Hematopoietic Cell ◽

Phase I Clinical Trial ◽

Cell Transplant ◽

Hematopoietic Cell Transplant ◽

High Risk Patients ◽

Risk Patients

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First-in-human phase I clinical trial of NY-ESO-1 protein cancer vaccine with a novel adjuvant MIS416, NOD2 and TLR9 stimulant, for patients with NY-ESO-1 expressing solid tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.15_suppl.e15176 ◽

2018 ◽

Vol 36 (15_suppl) ◽

pp. e15176-e15176 ◽

Cited By ~ 1

Author(s):

Mikiya Ishihara ◽

Yasutaka Tono ◽

Yoshihiro Miyahara ◽

Naozumi Harada ◽

Shinichi Kageyama ◽

...

Keyword(s):

Clinical Trial ◽

Phase I ◽

Solid Tumors ◽

Cancer Vaccine ◽

Phase I Clinical Trial

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Phase I clinical trial of a five-peptide cancer vaccine combined with cyclophosphamide in advanced solid tumors

Clinical Immunology ◽

10.1016/j.clim.2016.03.015 ◽

2016 ◽

Vol 166-167 ◽

pp. 48-58 ◽

Cited By ~ 21

Author(s):

Mutsunori Murahashi ◽

Yasuki Hijikata ◽

Kazunari Yamada ◽

Yoshihiro Tanaka ◽

Junji Kishimoto ◽

...

Keyword(s):

Clinical Trial ◽

Phase I ◽

Solid Tumors ◽

Cancer Vaccine ◽

Phase I Clinical Trial ◽

Advanced Solid Tumors

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Abstract B009: Phase I clinical trial of a PSA, IL-2, GM-CSF containing prostate cancer vaccine in PSA defined biochemical recurrent prostate cancer patients

10.1158/2326-6066.imm2016-b009 ◽

2016 ◽

Author(s):

Jonathan F. Head ◽

Gregory A. Daniels ◽

Michelle McKinney ◽

Weg Ongkeko ◽

Kyoko Sakamoto ◽

...

Keyword(s):

Prostate Cancer ◽

Clinical Trial ◽

Phase I ◽

Cancer Patients ◽

Cancer Vaccine ◽

Phase I Clinical Trial ◽

Recurrent Prostate Cancer ◽

Gm Csf

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First-in-human phase I clinical trial of the NY-ESO-1 protein cancer vaccine with NOD2 and TLR9 stimulants in patients with NY-ESO-1-expressing refractory solid tumors

Cancer Immunology Immunotherapy ◽

10.1007/s00262-020-02483-1 ◽

2020 ◽

Vol 69 (4) ◽

pp. 663-675 ◽

Cited By ~ 2

Author(s):

Mikiya Ishihara ◽

Yasutaka Tono ◽

Yoshihiro Miyahara ◽

Daisuke Muraoka ◽

Naozumi Harada ◽

...

Keyword(s):

Clinical Trial ◽

Phase I ◽

Solid Tumors ◽

Cancer Vaccine ◽

Phase I Clinical Trial

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A phase I clinical trial to study the safety of treatment with tipifarnib combined with bortezomib in patients with advanced stages of myelodysplastic syndrome and oligoblastic acute myeloid leukemia

Leukemia Research ◽

10.1016/j.leukres.2021.106573 ◽

2021 ◽

Vol 105 ◽

pp. 106573

Author(s):

Petra Muus ◽

Saskia Langemeijer ◽

Sandra van Bijnen ◽

Nicole Blijlevens ◽

Theo de Witte

Keyword(s):

Clinical Trial ◽

Acute Myeloid Leukemia ◽

Myelodysplastic Syndrome ◽

Phase I ◽

Myeloid Leukemia ◽

Phase I Clinical Trial ◽

Advanced Stages ◽

Acute Myeloid

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Phase I Clinical Trial of Cancer Vaccine Combined with Chemotherapy Targeting both Tumor Antigen and Immune Tolerance Against Advanced Solid Tumors

Annals of Oncology ◽

10.1016/s0923-7534(20)34216-2 ◽

2012 ◽

Vol 23 ◽

pp. ix536

Author(s):

M. Murahashi ◽

Y. Hijikata ◽

Y. Tanaka ◽

H. Inoue ◽

T. Marumoto ◽

...

Keyword(s):

Clinical Trial ◽

Phase I ◽

Solid Tumors ◽

Cancer Vaccine ◽

Immune Tolerance ◽

Tumor Antigen ◽

Phase I Clinical Trial ◽

Advanced Solid Tumors

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Abstract A004: HER2 cancer vaccine phase I clinical trial shows clinical benefit in 54% of evaluable patients

10.1158/2326-6074.cricimteatiaacr18-a004 ◽

2019 ◽

Cited By ~ 1

Author(s):

Jay A. Berzofsky ◽

Lauren V. Wood ◽

Hoyoung Maeng ◽

Jane Trepel ◽

David Stroncek ◽

...

Keyword(s):

Clinical Trial ◽

Phase I ◽

Cancer Vaccine ◽

Clinical Benefit ◽

Phase I Clinical Trial

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Phase I clinical trial of cancer vaccine with five novel epitope peptides for patients with metastatic colorectal cancer (mCRC).

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.15_suppl.2510 ◽

2011 ◽

Vol 29 (15_suppl) ◽

pp. 2510-2510 ◽

Cited By ~ 1

Author(s):

S. Hazama ◽

M. Oka ◽

K. Yoshida ◽

T. Tsunoda ◽

S. Yoshino ◽

...

Keyword(s):

Colorectal Cancer ◽

Clinical Trial ◽

Phase I ◽

Metastatic Colorectal Cancer ◽

Cancer Vaccine ◽

Phase I Clinical Trial

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