Clinicopathological Significance of Papillary Thyroid Carcinoma Located in the Isthmus: A Meta-Analysis

2021 ◽  
Author(s):  
Young Sang Lyu ◽  
Jung Soo Pyo ◽  
Won Jin Cho ◽  
Sang Yong Kim ◽  
Jin Hwa Kim
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Meta Analysis ◽  
Papillary Thyroid ◽  
Clinicopathological Significance

scholarly journals Clinicopathological Significance of Loss of p27Kip1 Expression in Papillary Thyroid Carcinoma

2017 ◽  
Vol 32 (2) ◽  
pp. 255-259 ◽  
Author(s):  
Nae Yu Kim ◽  
Jin Hwa Kim ◽  
Jung-Soo Pyo ◽  
Won Jin Cho
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Meta Analysis ◽  
Thyroid Tissue ◽  
Clinicopathological Characteristics ◽  
Papillary Thyroid ◽  
Benign Lesions ◽  
Thyroid Microcarcinoma ◽  
Clinicopathological Significance ◽  
Expression Loss

Introduction A meta-analysis was done to investigate the clinicopathological significance of the loss of p27kip1 expression in papillary thyroid carcinoma (PTC). Methods The meta-analysis involving 17 studies included 1,652 PTC and 328 benign cases. The rate of p27kip1 expression loss in PTC and benign lesions, and the correlations between p27kip1 expression loss and clinicopathological characteristics of PTC were determined. Results The estimated rate of p27kip1 expression loss was 0.557 (95% confidence interval [CI] 0.443-0.665) and 0.139 (95% CI 0.062-0.283) in PTC and benign lesions, respectively. In subgroup analysis, the rates of p27kip1 expression loss were 0.683, 0.393, and 0.414 in the classical variant, follicular variant, and papillary thyroid microcarcinoma, respectively. Loss of p27kip1 expression was significantly correlated with lymph node metastasis and distant metastasis (odds ratio 3.559, 95% CI 1.146-11.056 and 4.735, 95% CI 1.322-16.960, respectively). Extrathyroidal extension was correlated with loss of p27kip1 expression, but not in a statistically significant way (p = 0.051). There were no significant correlations between loss of p27kip1 expression and sex, tumor size, BRAFV600E mutation, and tumor multifocality. Conclusions Loss of p27kip1 expression is frequently found in PTC compared with benign lesions and normal thyroid tissue. When present in PTC, it is correlated with aggressive tumor behavior.

Associations between rs965513/rs944289 and papillary thyroid carcinoma risk: a meta-analysis

Endocrine ◽  
2014 ◽  
Vol 47 (2) ◽  
pp. 428-434 ◽  
Author(s):  
Lizhe Ai ◽  
Xiaoli Liu ◽  
Yuhang Yao ◽  
Yaqin Yu ◽  
Hui Sun ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Meta Analysis ◽  
Papillary Thyroid ◽  
Carcinoma Risk

miR-146a rs2910164 Polymorphism and Risk of Papillary Thyroid Carcinoma: A Meta-Analysis

2018 ◽  
Vol 22 (12) ◽  
pp. 674-679
Author(s):  
Huanhuan Chen ◽  
Hao Zhang ◽  
Yin Liu ◽  
Zhihui Chen ◽  
Jingyu Gu ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Meta Analysis ◽  
Papillary Thyroid
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