Clinicopathological significance of the single nucleotide polymorphism, rs2853669 within the TERT promoter in papillary thyroid carcinoma

2020 ◽  
Vol 70 (4) ◽  
pp. 217-223
Author(s):  
Tatsuya Hirokawa ◽  
Yuu Arimasu ◽  
Tomohiro Chiba ◽  
Masachika Fujiwara ◽  
Hiroshi Kamma
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Tert Promoter ◽  
Clinicopathological Significance

MMP-9-1562 C/T single nucleotide polymorphism associates with increased MMP-9 level and activity during papillary thyroid carcinoma progression

Pathology ◽  
2019 ◽  
Vol 51 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Jelena Roncevic ◽  
Ilona Djoric ◽  
Sonja Selemetjev ◽  
Jelena Jankovic ◽  
Tijana Isic Dencic ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

Effect of single‐nucleotide polymorphism in TERT promoter on follicular thyroid tumor development

2020 ◽  
Vol 70 (4) ◽  
pp. 210-216
Author(s):  
Tatsuya Hirokawa ◽  
Yuu Arimasu ◽  
Yoko Nakazato ◽  
Tomohiro Chiba ◽  
Masachika Fujiwara ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Tumor Development ◽  
Thyroid Tumor ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Tert Promoter

scholarly journals Clinicopathological Significance of Loss of p27Kip1 Expression in Papillary Thyroid Carcinoma

2017 ◽  
Vol 32 (2) ◽  
pp. 255-259 ◽  
Author(s):  
Nae Yu Kim ◽  
Jin Hwa Kim ◽  
Jung-Soo Pyo ◽  
Won Jin Cho
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Meta Analysis ◽  
Thyroid Tissue ◽  
Clinicopathological Characteristics ◽  
Papillary Thyroid ◽  
Benign Lesions ◽  
Thyroid Microcarcinoma ◽  
Clinicopathological Significance ◽  
Expression Loss

Introduction A meta-analysis was done to investigate the clinicopathological significance of the loss of p27kip1 expression in papillary thyroid carcinoma (PTC). Methods The meta-analysis involving 17 studies included 1,652 PTC and 328 benign cases. The rate of p27kip1 expression loss in PTC and benign lesions, and the correlations between p27kip1 expression loss and clinicopathological characteristics of PTC were determined. Results The estimated rate of p27kip1 expression loss was 0.557 (95% confidence interval [CI] 0.443-0.665) and 0.139 (95% CI 0.062-0.283) in PTC and benign lesions, respectively. In subgroup analysis, the rates of p27kip1 expression loss were 0.683, 0.393, and 0.414 in the classical variant, follicular variant, and papillary thyroid microcarcinoma, respectively. Loss of p27kip1 expression was significantly correlated with lymph node metastasis and distant metastasis (odds ratio 3.559, 95% CI 1.146-11.056 and 4.735, 95% CI 1.322-16.960, respectively). Extrathyroidal extension was correlated with loss of p27kip1 expression, but not in a statistically significant way (p = 0.051). There were no significant correlations between loss of p27kip1 expression and sex, tumor size, BRAFV600E mutation, and tumor multifocality. Conclusions Loss of p27kip1 expression is frequently found in PTC compared with benign lesions and normal thyroid tissue. When present in PTC, it is correlated with aggressive tumor behavior.

Coexistence of TERT Promoter and BRAF Mutations in Papillary Thyroid Carcinoma: Added Value in Patient Prognosis?

2015 ◽  
Vol 33 (6) ◽  
pp. 667-668 ◽  
Author(s):  
Miguel Melo ◽  
Adriana Gaspar da Rocha ◽  
João Vinagre ◽  
Manuel Sobrinho-Simões ◽  
Paula Soares
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Added Value ◽  
Papillary Thyroid ◽  
Braf Mutations ◽  
Tert Promoter ◽  
Patient Prognosis

scholarly journals Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients

2021 ◽  
Vol 48 (1) ◽  
pp. 1-8
Author(s):  
K. Vidinov ◽  
R. Dodova ◽  
P. Mitev ◽  
A. Mitkova ◽  
I. Dimitrova ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Genome Stability ◽  
Molecular Genetic ◽  
Molecular Genetic Analysis ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Single Nucleotide ◽  
Clinicopathological Significance ◽  
Present Pilot Study

Abstract Introduction: Thyroid carcinoma is the most common endocrine cancer. Some somatic mutations in genes (BRAF, NRAS and TERT) involved in key signaling pathways and genome stability have been recently identified to play an important role in its development. Very little research has been done on their frequency and clinical relevance in Bulgarian patients with papillary thyroid cancer (PTC). This study is focused on investigating somatic mutation frequency in Bulgarian patients with PTC and their association with clinicopathologic features. Material and Methods: The study included 50 PTC from Bulgarian patients analyzed for mutations in BRAF (V600E), NRAS (Q61K), single nucleotide polymorphism (SNP) rs2853669 and TERT (C228T and C250T) genes by Sanger sequencing. The results were interpreted using Benchling and SeqScape software, and statistical analysis performed with SPSS. Results: In the studied PTC group BRAF(V600E) and TERT (C228T) mutations were found with frequency of 24% and 2%, respectively. Co-occurrence of both mutations was found in 1 patient (2%). The mutations Q61K (NRAS), and C250T (TERT) were not detected. The SNP rs2853669 was found in 18 patients (52.9%). Correlation analysis with the clinical characteristics of the patients revealed statistically significant association with larger size of the tumor for BRAF(V600E) and smaller tumor size for rs2853669. Conclusion: In the present pilot study, we found that BRAF(V600E) and rs2853669 in TERT are common among PCT patients. While the presence of BRAF V600E mutation was associated with large tumors, the presence of rs2853669 in TERT was found in the majority of PCT below 2 cm. More extensive molecular genetic analysis of TERT, BRAF or RAS mutations in larger sample is needed to further elucidate the clinically important diagnostic and prognostic biomarkers for thyroid cancer.

Suspicious ultrasound and clinicopathological features of papillary thyroid carcinoma predict the status of TERT promoter

Endocrine ◽  
2020 ◽  
Vol 68 (2) ◽  
pp. 349-357
Author(s):  
Hui Shi ◽  
Le-Hang Guo ◽  
Yi-Feng Zhang ◽  
Hui-Jun Fu ◽  
Jia-Yi Zheng ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Clinicopathological Features ◽  
Papillary Thyroid ◽  
Tert Promoter ◽  
The Status
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