The Potential Role of Optical Coherence Tomography in the Evaluation of Vulnerable Carotid Atheromatous Plaques: A Pilot Study

OBJECTIVEApproximately 10% of patients with subarachnoid hemorrhage (SAH) become permanently, legally blind. The average cost of lifetime support and unpaid taxes for each blind person amounts to approximately $900,000. This study evaluates the feasibility and potential role of bedside optical coherence tomography (OCT) in Terson’s syndrome (TS) in patients with acute SAH (aSAH) and its potential role in blindness prevention.METHODSThe authors conducted an open-label pilot study, in which 31 patients with an angiographic diagnosis of aSAH were first screened for TS with dilated funduscopy and then with OCT in the acute phase and at 6-week follow-up visits. Outpatient mood assessments (Patient Health Questionnaire–depression module, Hamilton Depression Scale), and quality of life general (NIH Patient-Reported Outcomes Measurement Information System) and visual scales (25-item National Eye Institute Visual Functioning Questionnaire) were measured at 1 and 6 weeks after discharge. Exclusion criteria included current or previous history of severe cataracts, severe diabetic retinopathy, severe macular degeneration, or glaucoma.RESULTSOCT identified 7 patients with TS, i.e., a 22.6% incidence in our aSAH sample: 7 in the acute phase, including a large retinal detachment that was initially missed by funduscopy and diagnosed by OCT in follow-up clinic. Dilated retinal funduscopy significantly failed to detect TS in 4 (57.1%) of these 7 cases. Intraventricular hemorrhage was significantly more common in TS cases (85.7% vs 25%). None of the participants experienced any complications from OCT examinations. Neither decreased quality of life visual scale scores nor a depressed mood correlated with objective OCT pathological findings at the 6-week follow-up after discharge. There were no significant mood differences between TS cases and controls.CONCLUSIONSOCT is the gold standard in retinal disease diagnosis. This pilot study shows that bedside OCT examination is feasible in aSAH. In this series, OCT was a safe procedure that enhanced TS detection by decreasing false-negative/inconclusive funduscopic examinations. It allows early diagnosis of macular holes and severe retinal detachments, which require acute surgical therapy to prevent legal blindness. In addition, OCT aids in ruling out potential false-positive visual deficits in individuals with a depressed mood at follow-up.

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The Role of Anterior Segment Optical Coherence Tomography in Glaucoma

Journal of Ophthalmology ◽

10.1155/2012/476801 ◽

2012 ◽

Vol 2012 ◽

pp. 1-9 ◽

Cited By ~ 14

Author(s):

Sarwat Salim

Keyword(s):

Optical Coherence Tomography ◽

Potential Role ◽

Open Angle Glaucoma ◽

Anterior Segment ◽

Ultrasound Biomicroscopy ◽

Angle Closure ◽

Optical Coherence ◽

Potential Benefits ◽

Quantitative Analyses

The anterior segment optical coherence tomography provides an objective method to assess the anterior segment of the eye, including the anatomy of the anterior chamber angle. This technology allows both qualitative and quantitative analyses of the angle and has shown potential in detecting and managing angle-closure glaucoma. In addition, it has a role in identifying pathology in some forms of secondary open-angle glaucoma and postsurgical management of glaucoma. Limitations of this technology include its cost and inability to visualize well structures posterior to the iris, such as the ciliary body. This paper focuses on potential benefits and limitations of anterior segment optical coherence tomography when compared with conventional gonioscopy and ultrasound biomicroscopy. Various clinical entities will be described to discuss its potential role in glaucoma practice.

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Intraoperative Imaging Modalities and the Potential Role of Speckle Modulating Optical Coherence Tomography

Neurosurgery ◽

10.1093/neuros/nyy199 ◽

2018 ◽

Vol 65 (CN_suppl_1) ◽

pp. 74-77

Author(s):

Derek Yecies ◽

Orly Liba ◽

Adam de la Zerda ◽

Gerald A Grant

Keyword(s):

Optical Coherence Tomography ◽

Potential Role ◽

Intraoperative Imaging ◽

Imaging Modalities ◽

Optical Coherence

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The potential role of in vivo optical coherence tomography for evaluating oral soft tissue: A systematic review

Journal of Oral Pathology and Medicine ◽

10.1111/jop.12589 ◽

2017 ◽

Cited By ~ 4

Author(s):

Enrica Gentile ◽

Claudio Maio ◽

Antonio Romano ◽

Luigi Laino ◽

Alberta Lucchese

Keyword(s):

Systematic Review ◽

Optical Coherence Tomography ◽

Soft Tissue ◽

Potential Role ◽

Optical Coherence ◽

Oral Soft Tissue

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The role of optical coherence tomography as a predictor of cognitive impairment in multiple sclerosis

10.26226/morressier.5b719e465aff74008ae4cdaa ◽

2018 ◽

Author(s):

Cláudia Lima

Keyword(s):

Multiple Sclerosis ◽

Optical Coherence Tomography ◽

Cognitive Impairment ◽

Optical Coherence

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Carcinoma -associated Retinopathy(CAR): Role of Electroretinography(ERG) and Optical coherence Tomography(OCT) in diagnosis and predicting treatment outcome

American Journal of Ophthalmology Case Reports ◽

10.1016/j.ajoc.2020.101008 ◽

2021 ◽

Vol 21 ◽

pp. 101008

Author(s):

R. Neena ◽

Aarti Jain ◽

Giridhar Anantharaman ◽

Michelle Aline Antony

Keyword(s):

Optical Coherence Tomography ◽

Treatment Outcome ◽

Optical Coherence ◽

Predicting Treatment Outcome

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The role of quantitative deep capillary plexus in the pathogenesis of type 3 macular neovascularization: an optical coherence tomography angiography study

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-021-05330-w ◽

2021 ◽

Author(s):

Marina Concilio ◽

Federica Fossataro ◽

Daniela Montorio ◽

Mariapaola Giordano ◽

Gilda Cennamo

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Early Stage ◽

Study Groups ◽

Control Group ◽

Main Role ◽

Optical Coherence ◽

Capillary Plexus ◽

Type 3

Abstract Purpose To quantitatively investigate the role of deep capillary plexus (DCP) in patients affected by type 3 macular neovascularization (MNV), compared to patients with reticular pseudodrusen (RPD) eyes and healthy controls, using optical coherence tomography angiography (OCTA). Methods In this prospective observational study, a total of seventy-eight eyes of 78 patients were included. Group 1 consisted of 40 eyes of 40 patients with stage 1 of type 3 MNV (22 males, 18 females, mean age 73.7, SD ± 6.60) and group 2 included 38 eyes of 38 patients with RPD (17 males, 21 females, mean age 73.2, SD ± 4.55). The control group included 40 eyes of 40 healthy subjects (20 males, 20 females, mean age 71.4, SD ± 6.36 years). We evaluated the retinal vessel density (VD) of superficial capillary plexus (SCP) and deep capillary plexus (DCP) using OCTA. Results Patients with diagnosis of type 3 MNV showed statistically lower values of VD in DCP with respect to controls and to RPD group (p < 0.001), while there were no statistical differences between RPD and control group in macular region. No significant differences in VD of SCP were detected among the three study groups. Conclusion OCTA provides a reproducible, non-invasive detailed quantitative analysis of retinal vascular features and changing in early-stage type 3 MNV patients, which allowed to shed the light on the main role of DCP ischemia in the development of type 3 MNV.

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Retinal microcirculation abnormalities in patients with systemic sclerosis: an explorative optical coherence tomography angiography study

Rheumatology ◽

10.1093/rheumatology/keab258 ◽

2021 ◽

Author(s):

Adriano Carnevali ◽

Giuseppe Giannaccare ◽

Valentina Gatti ◽

Caterina Battaglia ◽

Giorgio Randazzo ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Flow Index ◽

Digital Ulcers ◽

Optical Coherence ◽

Vascular Abnormalities ◽

Capillary Plexus ◽

Retinal Microcirculation ◽

Vascular Plexuses

Abstract Objectives To investigate subclinical and clinical abnormalities in retinal and choroidal vascular plexuses in patients with SSc by means of optical coherence tomography angiography (OCT-A). Methods A total of 20 consecutive SSc patients were recruited and compared with 20 healthy subjects. Quantitative analysis of vessel density (VD), choriocapillaris plexus flow index (CCP-FI) and choroidal vascularity index were performed on OCT-A images in the superficial capillary plexus (SCP), deep capillary plexus (DCP) and CCP for all patients. Images were further reviewed by two independent readers for the assessment of qualitative abnormalities, including tortuosity, rarefaction areas, megacapillaries and macular-foveal capillaries. Results The DCP-VD in the whole scan and in the perifoveal, superior, inferior, nasal and temporal regions was significantly lower in the SSc group. The CCP-FI was significantly higher in SSc patients. When comparing SSc patients with and without digital ulcers, significantly decreased SCP-VD was demonstrated in the whole, perifoveal, superior, inferior, temporal and nasal regions. No difference in any of the OCT-A parameters was observed when comparing patients with and without interstitial lung disease. Qualitative analysis of OCT-A revealed at least one abnormality in 95% of patients. Conclusion We showed the ability of OCT-A to disclose early ocular vascular abnormalities in patients with SSc. Our results may represent a hypothesis-generating basis for exploring the potential role of OCT-A in diagnosis, monitoring and prognosis stratification in SSc.

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