603 Background: Analytic morphomics have emerged as promising biomarkers of post-surgical outcomes. Decision-making in patients with mRCC is nuanced, as benefits of cytoreductive nephrectomy (CN) must be balanced against risks of delaying or forgoing systemic therapy. We sought to identify if pre-operative morphometrics predict survival in patients undergoing CN. Methods: We reviewed clinical, histopathologic, and radiographic data for patients who underwent CN at our institution from 2006-2012. Pre-operative cross-sectional images of T12 to L4 were assessed. Subcutaneous fat content (average distance from skin to fascia in midline); visceral fat (average distance from fascia to anterior vertebral body); and total body fat (visceral + subcutaneous fat) were quantitated. Psoas muscle area and density at L4 were indexed. Primary outcomes were OS and DSS. Results: 62 patients had complete data for review. Median age at surgery was 60 years (range 40-77), Charlson score was 1 (0-5), and ECOG PS was 0 (0-2). There were 42 patients with lung , 26 with bone, 8 with liver, and 5 with brain metastases (average metastatic sites per patient = 1.8). 46 patients (75.4%) received adjuvant systemic therapy. At 16 months follow-up, 23 patients (37.1%) died from disease, while 17 (27.4%) died of other causes. Median survival following surgery was 13 months (range 1-75). Morphomic metrics did not correlate with survival (Table). Conclusions: Pre-operative morphometrics did not correlate with survival outcomes in a cohort of patients undergoing cytoreductive nephrectomy. Perhaps acuity of mRCC onset and speed of progression reduce prognostic value of morphometrics in this population. [Table: see text]
Psoas muscle area as a predictor of mortality and morbidity following endovascular aneurysm repair
