Analysis of the human brain in primary progressive multiple sclerosis with mapping of the spatial distributions using 1H MR spectroscopy and diffusion tensor imaging

Background: The research of primary progressive multiple sclerosis (PPMS) has not been able to capitalize on recent progresses in advanced magnetic resonance imaging (MRI) protocols.Objective: The presented cross-sectional study evaluated the utility of four different MRI relaxation metrics and diffusion-weighted imaging in PPMS.Methods: Conventional free precession T1 and T2, and rotating frame adiabatic T1ρ and T2ρ in combination with diffusion-weighted parameters were acquired in 13 PPMS patients and 13 age- and sex-matched controls.Results: T1ρ, a marker of crucial relevance for PPMS due to its sensitivity to neuronal loss, revealed large-scale changes in mesiotemporal structures, the sensorimotor cortex, and the cingulate, in combination with diffuse alterations in the white matter and cerebellum. T2ρ, particularly sensitive to local tissue background gradients and thus an indicator of iron accumulation, concurred with similar topography of damage, but of lower extent. Moreover, these adiabatic protocols outperformed both conventional T1 and T2 maps and diffusion tensor/kurtosis approaches, methods previously used in the MRI research of PPMS.Conclusion: This study introduces adiabatic T1ρ and T2ρ as elegant markers confirming large-scale cortical gray matter, cerebellar, and white matter alterations in PPMS invisible to other in vivo biomarkers.

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Correlation of proton MR spectroscopy and diffusion tensor imaging

Magnetic Resonance Imaging ◽

10.1016/j.mri.2005.06.005 ◽

2005 ◽

Vol 23 (8) ◽

pp. 851-858 ◽

Cited By ~ 23

Author(s):

Roy Irwan ◽

Paul E. Sijens ◽

Jan-Hendrik Potze ◽

Matthijs Oudkerk

Keyword(s):

Diffusion Tensor Imaging ◽

Mr Spectroscopy ◽

Diffusion Tensor ◽

Proton Mr Spectroscopy ◽

And Diffusion

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Effect of teriflunomide on gray and white matter brain pathology in multiple sclerosis using volumetric and diffusion-tensor imaging MRI measures

Journal of the Neurological Sciences ◽

10.1016/j.jns.2018.03.028 ◽

2018 ◽

Vol 388 ◽

pp. 175-181 ◽

Cited By ~ 8

Author(s):

Robert Zivadinov ◽

Niels Bergsland ◽

Jesper Hagemeier ◽

Ellen Carl ◽

Hanna Kolb ◽

...

Keyword(s):

Multiple Sclerosis ◽

Diffusion Tensor Imaging ◽

White Matter ◽

Diffusion Tensor ◽

Brain Pathology ◽

And Diffusion

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Alterations in sensorimotor and mesiotemporal cortices and diffuse white matter changes in primary progressive multiple sclerosis detected by adiabatic relaxometry

10.21203/rs.3.rs-85334/v1 ◽

2020 ◽

Author(s):

Pavel Filip ◽

Michal Dufek ◽

Silvia Mangia ◽

Shalom Michaeli ◽

Martin Bares ◽

...

Keyword(s):

Multiple Sclerosis ◽

White Matter ◽

Large Scale ◽

Diffusion Tensor ◽

Neuronal Loss ◽

Progressive Multiple Sclerosis ◽

Primary Progressive Multiple Sclerosis ◽

Primary Progressive ◽

T1 And T2

Abstract Background: The research of primary progressive multiple sclerosis (PPMS) has not been able to capitalize on recent progresses in advanced MRI protocols searching for disease-specific microstructural changes. Methods: Conventional free precession T1 and T2, and rotating frame adiabatic T1ρ and T2ρ maps in combination with diffusion weighted parameters were acquired in 13 PPMS patients and 13 age and sex-matched controls.Results: T1ρ, a marker of crucial relevance for PPMS due to its sensitivity to neuronal loss, revealed large-scale changes in mesiotemporal structures, sensorimotor cortex and cingulate, in combination with diffuse alterations in the white matter and cerebellum. T2ρ, particularly sensitive to local tissue background gradients and thus indicator of iron accumulation, concurred with similar topography of damage, but of lower extent. Moreover, these adiabatic protocols completely dwarfed the outcomes of both conventional T1 and T2 maps and diffusion tensor/kurtosis approaches –methods previously implicated in the MRI research of PPMS.Conclusion: This study introduces adiabatic T1ρ and T2ρ as elegant markers confirming large-scale cortical grey matter, cerebellar and white matter alterations in PPMS invisible to other in vivo biomarkers.

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