scholarly journals Signal characteristics of focal bone marrow lesions in patients with multiple myeloma using whole body T1w-TSE, T2w-STIR and diffusion-weighted imaging with background suppression

2010 ◽  
Vol 21 (4) ◽  
pp. 857-862 ◽  
Author(s):  
Gregor Sommer ◽  
Markus Klarhöfer ◽  
Claudia Lenz ◽  
Klaus Scheffler ◽  
Georg Bongartz ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Diffusion Weighted Imaging ◽  
Whole Body ◽  
Background Suppression ◽  
Bone Marrow Lesions ◽  
Diffusion Weighted ◽  
Signal Characteristics ◽  
And Diffusion

Signal characteristics of normal adult bone marrow in whole-body diffusion-weighted imaging

2016 ◽  
Vol 57 (10) ◽  
pp. 1230-1237 ◽  
Author(s):  
Feng-Zhen Cui ◽  
Jian-Ling Cui ◽  
Shi-Lei Wang ◽  
Hong Yu ◽  
Ying-Cai Sun ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Diffusion Weighted Imaging ◽  
Normal Adult ◽  
Whole Body ◽  
Adult Bone Marrow ◽  
Diffusion Weighted ◽  
Signal Characteristics ◽  
Adult Bone

scholarly journals Artifact-robust diffusion-weighted whole-body imaging with background suppression at 3 T using improved turbo spin-echo diffusion-weighted imaging

2019 ◽  
Vol 92 (1094) ◽  
pp. 20180489 ◽  
Author(s):  
Makoto Suzuki ◽  
Satoru Morita ◽  
Yasuhiro Goto ◽  
Hitoshi Tadenuma ◽  
Yu Nishina ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Spin Echo ◽  
Whole Body ◽  
Background Suppression ◽  
Whole Body Imaging ◽  
Turbo Spin Echo ◽  
Body Imaging ◽  
Turbo Spin ◽  
Diffusion Weighted

scholarly journals Association of loss of spleen visualization on whole-body diffusion-weighted imaging with prognosis and tumor burden in patients with multiple myeloma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Toshiki Terao ◽  
Youichi Machida ◽  
Ukihide Tateishi ◽  
Takafumi Tsushima ◽  
Kentaro Narita ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Diffusion Weighted Imaging ◽  
Plasma Cells ◽  
Progression Free Survival ◽  
Myeloma Cell ◽  
Extramedullary Hematopoiesis ◽  
Tumor Burden ◽  
Whole Body ◽  
Diffusion Weighted ◽  
Worse Prognosis

AbstractThis study investigated the clinical significance of loss of spleen visualization (LSV) on whole-body diffusion-weighted imaging (WB-DWI) in patients with multiple myeloma (MM). The WB-DWI of 96 patients with newly diagnosed MM (NDMM) and 15 patients with smoldering MM (sMM) were retrospectively reviewed. LSV was observed in 56 patients with NDMM (58.3%) and 1 patient with sMM (6.7%). Patients with NDMM with LSV had a higher median infiltration of bone marrow plasma cells (80.0% vs. 50.0%, p < 0.001) and median total diffusion volume (median; 540.2 vs. 137.0 mL, p = 0.003) than patients without LSV. Patients with LSV had a lower spleen-to-spinal cord ratio (0.36 vs. 0.96, p < 0.001) and worse 2-year overall survival (OS) (84.6% vs. 100%, p = 0.032). Patients who did not recover spleen visualization during treatment had a worse prognosis, even when they obtained very good partial response (median progression-free survival: 13.2 months). Spleen histopathological findings revealed higher cellularity and diffuse myeloma cell infiltration in a patient with LSV and splenic amyloidosis without extramedullary hematopoiesis in a patient without LSV. Therefore, LSV indicates worse prognosis for patients with MM, even when the patient responds to treatment. Further studies are warranted to clarify the immunological role of spleen in MM.

scholarly journals BONE MARROW LESIONS: DIAGNOSIS WITHOUT BIOPSY

2019 ◽  
pp. 19-25
Author(s):  
Yu. V. Nazinkina
Keyword(s):  
Bone Marrow ◽  
Chemical Shift ◽  
Diffusion Weighted Imaging ◽  
Pulse Sequence ◽  
Pulse Sequences ◽  
Bone Marrow Lesions ◽  
Bone Marrow Diseases ◽  
Standard Pulse ◽  
Spinal Mri ◽  
And Diffusion

Routine spinal MRI can be used for bone marrow lesions detection. The most useful standard pulse sequence is T1- WI, which helps both in local and diffuse bone marrow diseases. Additional new pulse sequences, including chemical shift imaging and diffusion weighted imaging, can be used as solving-problem techniques.

scholarly journals Whole Body Diffusion Weighted MRI (WB DWI) for the Management of Multiple Myeloma: High Concordance between MRI Diffuse Pattern and BONE Marrow Plasma CELL Infiltration RATE

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 5495-5495
Author(s):  
Silvia Mangiacavalli ◽  
Zacchino Michela ◽  
Virginia Valeria Ferretti ◽  
Claudio Salvatore Cartia ◽  
Giovanni Savietto ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Progressive Disease ◽  
Infiltration Rate ◽  
Whole Body ◽  
Radiological Findings ◽  
Focal Lesions ◽  
Diffuse Infiltration ◽  
Diffusion Weighted ◽  
Weighted Sequences

Background: Diffusion-weighted whole body MRI (WB-DWI) is a new functional imaging technique comprising anatomical and functional sequences with an emerging role in the management of multiple myeloma (MM) patients (pts) since it allows highly sensitive detection of diffuse bone marrow (BM) infiltration pattern and focal lesions, avoiding intravenous injections and radiation exposure. The aims of our study were 1) to test the correlation between plasma cells infiltration (BMPC) rate at BM biopsy and the presence of diffuse infiltration pattern at WB-DWI. 2) to compare response according to IMWG criteria and WB-DWI response and to establish the rate of discordancy (WB-DWI progression with increased focal lesions and at least a partial response according to IMWG criteria) Methods: We reviewed data regarding 45 MM patients (pts) observed in our Centre between September 2018 and July 2019 for whom quantification of serum and urine monoclonal component (MC), free light chains value (FLC), BM biopsy, whole body CT scan and WB-DWI data were available at the same time point. Sequential assessment of WB-DWI and laboratory data was available in 20 pts. Patients performed a WB-DWI (Magnetom Area, 1.5T, Siemens Enlarged Germany) for head to knee. The protocol included anatomical sequences T1 and T2 weighted with fat suppression on the sagittal plane specifically for the spine. Coronal T2 weighted fat suppression sequences are performed for the study of femural bone. Axial Dixon T1 weighted sequences of the whole scan region, in breath-old. The functional part is formed by diffusion weighted sequences in the axial plane. MM diagnosis and response were assessed by IMWG criteria. Response were categorized as follows: responsive patients if ≥PR, progressive disease if <PR. BM infiltration rate was used as a continuous variable. WB-DWI findings at first evaluation were categorized as follows: presence/absence of focal lesions, presence/absence of diffuse pattern of BM infiltration. Radiological re-assessment of both focal lesions and diffuse pattern was categorized as follows: reduced/stable/increased. Discordant pattern of progression was defined as: ≥PR + diffuse pattern stable/reduced + focal lesions increased. Association between two categorical variables was evaluated by Fisher's exact test. Mann-Whitney test was used to compare a quantitative variable among two independent groups of patients. P-values<0.05 were considered significant. Results: Table 1 summarizes the clinical and radiological data of the population on study. Median age was 64 years (range 38-86), median number of previous lines of therapy at time of evaluation was 0 (range 0-)2; 47% pts were at the onset, 31% were in follow-up after treatment completion, 22% had progressive disease. WB-DWI showed a diffuse pattern in 22 pts (49%); in 23 patients without a diffuse pattern, 7 (30%) had PBMC >10%; BMPC infiltration rate was significantly higher in pts with presence of diffuse pattern at WB-DWI (p<0.001; Figure 1). WB-DWI showed focal lesions in 35 pts (78%): 19 of them were at onset of disease. Most of the patients performing sequential assessment of WB-DWI were responsive according to IMWG criteria at time of WB-DWI re-evaluation (17 pts with ≥PR, 85%). Table 2 shows radiological findings according to IMWG response. Focusing on patients with ≥PR, WB-DWI diffuse pattern was reduced in 13 pts (76.5%) and stable in 4 pts (23.5%) with complete concordance between hematological and radiological findings (increased diffuse pattern in no pt with ≥PR); focal lesions were reduced in 76.5% and increased in 23.5%; a discordant pattern of progression was found in 4 patients (20%). Conclusions: Our study findsa significant correlation between presence of WB-DWI diffuse infiltration patter and BMPC rate, highlighting the possible future use of this radiological technique for monitoring BM residual disease. In addition, this study shows the possible not negligible emergence of discordant pattern of progression, probably deriving from the spatial heterogeneity of MM clones and their different sensitivity to therapy. Disclosures Mangiacavalli: celgene: Consultancy; Janssen cilag: Consultancy; Amgen: Consultancy. Varettoni:Gilead: Other: travel expenses; ABBVIE: Other: travel expenses; Roche: Consultancy; Janssen: Consultancy. Arcaini:Celgene: Speakers Bureau; Celgene, Roche, Janssen-Cilag, Gilead: Other: Travel expenses; Gilead Sciences: Research Funding; Bayer, Celgene, Gilead Sciences, Roche, Sandoz, Janssen-Cilag, VERASTEM: Consultancy.

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