Osteoarthritis is one of the most common disorders in joint disease. It is characterized by pain, shiftiness, decreased range of motion which is very close to Sandhigatavat. Sandhigatavat is amongst 80 Nanatmaj Vat Vyadhi. Here is a case of 57 years old male patient who was having complaints of pain, tenderness, crepitus, swelling and restricted movement of both knee joints. Based on these symptoms and clinical sign he was diagnosed as a case of Sandhigatvat. Treatment given to this patient was Snehan, Swedan, Janubasti, Yog, Basti and oral medication . Assessment of patient before and after treatment was done on the basis of pain, tenderness and physical activity to exclude the efficacy of the treatment. Based on assessment parameter, moderate improvement was seen in subjective sign & symptoms after the completion of Schedule of IPD treatment & 1 month follow up. The pain & physical activity were improved significantly.