Identification and mapping of 26 human testis mRNAs containing CAG/CTG repeats

1998 ◽  
Vol 9 (9) ◽  
pp. 745-748 ◽  
Author(s):  
A. Pawlak ◽  
N. Chiannikulchai ◽  
W. Ansorge ◽  
F. Bulle ◽  
J. Weissenbach ◽  
...  
Keyword(s):  
Human Testis ◽  
Ctg Repeats

scholarly journals Sporadic testicular germ cell cancers do not exhibit specific alteration in CAG/CTG repeats containing genes expressed in human testis

Oncogene ◽  
2001 ◽  
Vol 20 (39) ◽  
pp. 5548-5553 ◽  
Author(s):  
Yasumasa Ono ◽  
Eva Rajpert De-Meyts ◽  
Georges Guellaën ◽  
Frédérique Bulle
Keyword(s):  
Germ Cell ◽  
Human Testis ◽  
Testicular Germ Cell ◽  
Ctg Repeats ◽  
Specific Alteration

Myotonic dystrophy Rossolimo-Churchman-Steinert-Batten (clinical case)

2020 ◽  
pp. 71-72
Author(s):  
И.А. Синельникова ◽  
И.В. Сопрунова ◽  
О.П. Николаева
Keyword(s):  
Case Report ◽  
Myotonic Dystrophy ◽  
Clinical Case ◽  
Molecular Genetic ◽  
Ctg Repeats ◽  
Molecular Genetic Method ◽  
Genetic Method ◽  
Family Case ◽  
Dmpk Gene

В статье представлено описание семейного случая миотонической дистрофии Россолимо-Штейнерта-Куршмана-Баттена. Диагноз подтвержден в результате ДНК-диагностики: выявлено увеличенное число копий CTG-повтора гена DMPK, ответственного за развитие миотонической дистрофии. A family case report of Rossolimo-Steinert-Curschmann myotonic dystrophy is presented. An increased number of copies of CTG-repeats of the DMPK gene responsible for the development of MD, i.e., the diagnosis was confirmed by molecular genetic method.

scholarly journals Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells

2001 ◽  
Vol 6 (12) ◽  
pp. 1077-1090 ◽  
Author(s):  
Christine M. Sadek ◽  
Anastasios E. Damdimopoulos ◽  
Markku Pelto-Huikko ◽  
Jan-Åke Gustafsson ◽  
Giannis Spyrou ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Germ Cells ◽  
Human Testis ◽  
Ndp Kinase

Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in human testis

Life Sciences ◽  
2002 ◽  
Vol 71 (23) ◽  
pp. 2741-2757 ◽  
Author(s):  
Li Jun Cheng ◽  
Zuo Min Zhou ◽  
Jian Min Li ◽  
Hui Zhu ◽  
Hu Zhu ◽  
...  
Keyword(s):  
Splice Variant ◽  
Human Testis ◽  
Mrna Splice

Improvement in Spermatogenesis Following Depression of the Human Testis with Testosterone

1950 ◽  
Vol 1 (5) ◽  
pp. 415-422 ◽  
Author(s):  
Carl G. Heller ◽  
Warren O. Nelson ◽  
Irvin B. Hill ◽  
Edward Henderson ◽  
William O. Maddock ◽  
...  
Keyword(s):  
Human Testis

Studies on the structure and function of the mammalian testis V. Steroid metabolism by isolated interstitium and seminiferous tubules of the human testis

1974 ◽  
Vol 186 (1083) ◽  
pp. 99-120 ◽  
Keyword(s):  
Metabolic Activity ◽  
General Pattern ◽  
Steroid Metabolism ◽  
Human Testis ◽  
Clinical Aspects ◽  
Seminiferous Tubules ◽  
Bicarbonate Buffer ◽  
The Media ◽  
The Individual ◽  
And Function

Tissue was obtained from the testes of three men, two in the age range 72-75 years (subjects A and B) and one aged 25 years (subject C). Parts of the testes were dissected to obtain samples of interstitium and tubules. The individual components and whole tissue were each incubated with equimolar concentrations of [7 α - 3 H]pregnenolone and [4- 14 C]progesterone in Krebs-Ringer bicarbonate buffer pH 7.4, at 35 °C with the addition of glucose but without cofactors. Some incubations were carried out with the substrates [4- 14 C]androstenedione and [7 α - 3 H]testosterone. The media were extracted both at various time intervals throughout the incubation for a kinetic study of the metabolic activity and after a fixed interval of time at the end of the incubations. In some incubations with whole tissue both media and tissue were extracted. Both the tubules and interstitium displayed steroid metabolic activity. Qualitatively they yielded the same range of metabolites, one series leading to the formation of testosterone (∆ 5 pathway) and the other to a variety of C 21 compounds as represented by 5 α -pregnan-3 β -ol-20-one. With similar amounts of tissue there was little difference in the yields of the main products formed by the tubules as compared with those formed by the interstitium; in incubations with [4- 14 C]androstenedione the rate of conversion to [ 14 C ]testosterone by the tubules greatly exceeded that due to the interstitium. Marked differences were found in the pattern of steroid metabolism by whole tissue as compared to the general pattern presented by the corresponding tubules and interstitium. It is concluded that the seminiferous tubules and interstitium of the human testis are both capable of steroid metabolism and hence that whole tissue incubations alone are of limited value and could give rise to misleading data. Some clinical aspects of the results are briefly discussed.

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