Personalized application of machine learning algorithms to identify pediatric patients at risk for recurrent ureteropelvic junction obstruction after dismembered pyeloplasty

2021 ◽  
Author(s):  
Erik Drysdale ◽  
Adree Khondker ◽  
Jin K. Kim ◽  
Jethro C. C. Kwong ◽  
Lauren Erdman ◽  
...  
Keyword(s):  
Machine Learning ◽  
At Risk ◽  
Pediatric Patients ◽  
Ureteropelvic Junction Obstruction ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Ureteropelvic Junction ◽  
Patients At Risk

1290-P: Gut Microbiota in New-Onset Pediatric Patients with Type 1 Diabetes: Machine Learning Algorithms to Classify Microorganisms Disease-Linked

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1290-P
Author(s):  
GIUSEPPE D’ANNUNZIO ◽  
ROBERTO BIASSONI ◽  
MARGHERITA SQUILLARIO ◽  
ELISABETTA UGOLOTTI ◽  
ANNALISA BARLA ◽  
...  
Keyword(s):  
Machine Learning ◽  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Pediatric Patients ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
New Onset

scholarly journals Identifying those at risk of reattendance at discharge from emergency departments using explainable machine learning

2020 ◽  
Author(s):  
F. P. Chmiel ◽  
M. Azor ◽  
F. Borca ◽  
M. J. Boniface ◽  
D. K. Burns ◽  
...  
Keyword(s):  
Machine Learning ◽  
At Risk ◽  
Emergency Departments ◽  
Risk Groups ◽  
Machine Learning Algorithms ◽  
Care Indicator ◽  
Number Of Patients ◽  
Increased Risk ◽  
Single Centre Study ◽  
Patients At Risk

ABSTRACTShort-term reattendances to emergency departments are a key quality of care indicator. Identifying patients at increased risk of early reattendance can help reduce the number of patients with missed or undertreated illness or injury, and could support appropriate discharges with focused interventions. In this manuscript we present a retrospective, single-centre study where we create and evaluate a machine-learnt classifier trained to identify patients at risk of reattendance within 72 hours of discharge from an emergency department. On a patient hold-out test set, our highest performing classifier obtained an AUROC of 0.748 and an average precision of 0.250; demonstrating that machine-learning algorithms can be used to classify patients, with moderate performance, into low and high-risk groups for reattendance. In parallel to our predictive model we train an explanation model, capable of explaining predictions at an attendance level, which can be used to help inform the design of interventional strategies.

scholarly journals Predicting Obstetric Disease With Machine Learning Applied to Patient-Reported Data (Preprint)

2018 ◽  
Author(s):  
Danielle Bradley ◽  
Erin Landau ◽  
Adam Wolfberg ◽  
Alex Baron
Keyword(s):  
Machine Learning ◽  
At Risk ◽  
Mobile Apps ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Obstetric Outcomes ◽  
Patient Reported ◽  
Data Points ◽  
Reported Data

BACKGROUND The rise of highly engaging digital health mobile apps over the past few years has created repositories containing billions of patient-reported data points that have the potential to inform clinical research and advance medicine. OBJECTIVE To determine if self-reported data could be leveraged to create machine learning algorithms to predict the presence of, or risk for, obstetric outcomes and related conditions. METHODS More than 10 million women have downloaded Ovia Health’s three mobile apps (Ovia Fertility, Ovia Pregnancy, and Ovia Parenting). Data points logged by app users can include information about menstrual cycle, health history, current health status, nutrition habits, exercise activity, symptoms, or moods. Machine learning algorithms were developed using supervised machine learning methodologies, specifically, Gradient Boosting Decision Tree algorithms. Each algorithm was developed and trained using anywhere from 385 to 5770 features and data from 77,621 to 121,740 app users. RESULTS Algorithms were created to detect the risk of developing preeclampsia, gestational diabetes, and preterm delivery, as well as to identify the presence of existing preeclampsia. The positive predictive value (PPV) was set to 0.75 for all of the models, as this was the threshold where the researchers felt a clinical response—additional screening or testing—would be reasonable, due to the likelihood of a positive outcome. Sensitivity ranged from 24% to 75% across all models. When PPV was adjusted from 0.75 to 0.52, the sensitivity of the preeclampsia prediction algorithm rose from 24% to 85%. When PPV was adjusted from 0.75 to 0.65, the sensitivity of the preeclampsia detection or diagnostic algorithm increased from 37% to 79%. CONCLUSIONS Algorithms based on patient-reported data can predict serious obstetric conditions with accuracy levels sufficient to guide clinical screening by health care providers and health plans. Further research is needed to determine whether such an approach can improve outcomes for at-risk patients and reduce the cost of screening those not at risk. Presenting the results of these models to patients themselves could also provide important insight into otherwise unknown health risks.

scholarly journals The Right Time for Crowd Communication during Campaigns for Sustainable Success of Crowdfunding: Evidence from Kickstarter Platform

2020 ◽  
Vol 12 (18) ◽  
pp. 7642 ◽  
Author(s):  
Michael J. Ryoba ◽  
Shaojian Qu ◽  
Ying Ji ◽  
Deqiang Qu
Keyword(s):  
Machine Learning ◽  
At Risk ◽  
Prediction Accuracy ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Success Prediction ◽  
Combined Effects ◽  
Baseline Model ◽  
Predicting Success ◽  
The Right

Only a small percentage of crowdfunding projects succeed in securing funds, the fact of which puts the sustainability of crowdfunding platforms at risk. Researchers have examined the influences of phased aspects of communication, drawn from updates and comments, on success of crowdfunding campaigns, but in most cases they have focused on the combined effects of the aspects. This paper investigated campaign success contribution of various combinations of phased communication aspects from updates and comments, the best of which can help creators to successfully manage campaigns by focusing on the important communication aspects. Metaheuristic and machine learning algorithms were used to search and evaluate the best combination of phased communication aspects for predicting success using Kickstarter dataset. The study found that the number of updates in phase one, the polarity of comments in phase two, readability of updates and polarity of comments in phase three, and the polarity of comments in phase five are the most important communication aspects in predicting campaign success. Moreover, the success prediction accuracy with the aspects identified after phasing is more than the baseline model without phasing. Our findings can help crowdfunding actors to focus on the important communication aspects leading to improved likelihood of success.

scholarly journals Machine Learning and Statistical Approaches for Classification of Risk of Coronary Artery Disease using Plasma Cytokines.

2020 ◽  
Author(s):  
Seema Singh Saharan ◽  
Pankaj Nagar ◽  
Kate Townsend Creasy ◽  
Eveline O. Stock ◽  
James Feng ◽  
...  
Keyword(s):  
Machine Learning ◽  
Coronary Artery Disease ◽  
At Risk ◽  
Coronary Artery ◽  
Random Forest ◽  
Large Scale ◽  
Statistical Significance ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Artery Disease

Abstract Background As per the 2017 WHO fact sheet, Coronary Artery Disease (CAD) is the primary cause of death in the world, and accounts for 31% of total fatalities. The unprecedented 17.6 million deaths caused by CAD in 2016 underscores the urgent need to facilitate proactive and accelerated pre-emptive diagnosis. The current research took an innovative approach to implement K Nearest Neighbor (k-NN) and ensemble Random Forest Machine Learning algorithms to achieve a targeted “At Risk” Coronary Artery Disease (CAD) classification. To ensure better generalizability mechanisms like k-fold cross validation, hyperparameter tuning and statistical significance (p<.05) were employed. The classification is also unique from the aspect of incorporating 35 cytokines as biomarkers within the predictive feature space of Machine Learning algorithms.Results A total of seven classifiers were developed, with four built using 35 cytokine predictive features and three built using 9 cytokines statistically significant (p<.05) across CAD versus Control groups determined by independent two sample t tests. The best prediction accuracy of 100% was achieved by Random Forest ensemble using nine significant cytokines. Significant cytokines were selected to decrease the noise level of the data, allowing for better classification. Additionally, from the bio-medical perspective, it was enlightening to empirically observe the interplay of the cytokines. Compared to Controls, moderately correlated (correlation coefficient r=.5) cytokines “IL1-β”, “IL-10” were both significant and down regulated in the CAD group. Both cytokines were primarily responsible for the Random forest generated 100% classification. In conjunction with Machine Learning (ML) algorithms, the traditional statistical techniques like correlation and t tests were leveraged to obtain insights that brought forth a role for cytokines in the investigation of CAD risk.Conclusions Presently, as large-scale efforts are gaining momentum to enable early detection of individuals at risk for CAD by the application of novel and powerful ML algorithms, detection can be further improved by incorporating additional biomarkers. Investigation of emerging role of cytokines in CAD can materially enhance the detection of risk and the discovery of mechanisms of disease that can lead to new therapeutic approaches.

A Demonstration of Machine Learning in Detecting Frequency Following Responses in American Neonates

2020 ◽  
pp. 003151252096039
Author(s):  
Breanna N. Hart ◽  
Fuh-Cherng Jeng
Keyword(s):  
Machine Learning ◽  
At Risk ◽  
High Efficiency ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Pitch Processing ◽  
Intervention Services

In this study, we sought to evaluate the efficiencies of multiple machine learning algorithms in detecting neonates’ Frequency Following Responses (FFRs). We recorded continuous brainwaves from 43 American neonates in response to a pre-recorded monosyllable/i/with a rising frequency contour. Recordings were classified into response and no response categories. Six response features were extracted from each recording and served as predictors in FFR identification. Twenty-three supervised machine learning algorithms with mean efficiency values of 86.0%, 94.4%, 97.2%, and 97.5% when 1, 10, 100, and 1000 random iterations were implemented, respectively. These high efficiency values obtained from the neonatal FFRs demonstrate that machine learning algorithms can help assess pitch processing in neonates and can be applied to auditory screening and intervention services for neonates at risk for disorders associated with decreased pitch processing.

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