Therapeutic potential of spheroids of stem cells from human exfoliated deciduous teeth for chronic liver fibrosis and hemophilia A

2019 ◽  
Vol 35 (12) ◽  
pp. 1379-1388
Author(s):  
Yoshiaki Takahashi ◽  
Ratih Yuniartha ◽  
Takayoshi Yamaza ◽  
Soichiro Sonoda ◽  
Haruyoshi Yamaza ◽  
...  
Keyword(s):  
Stem Cells ◽  
Liver Fibrosis ◽  
Hemophilia A ◽  
Therapeutic Potential ◽  
Chronic Liver ◽  
Deciduous Teeth ◽  
Human Exfoliated Deciduous Teeth

scholarly journals In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Takayoshi Yamaza ◽  
Fatima Safira Alatas ◽  
Ratih Yuniartha ◽  
Haruyoshi Yamaza ◽  
Junko K. Fujiyoshi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Liver Fibrosis ◽  
Therapeutic Potential ◽  
Deciduous Teeth ◽  
Human Exfoliated Deciduous Teeth

Stem Cells Derived from Human Exfoliated Deciduous teeth [shed] in Neuronal Disorders: A Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Minu Anoop ◽  
Indrani Datta
Keyword(s):  
Stem Cells ◽  
Neurodegenerative Diseases ◽  
Dental Pulp ◽  
Therapeutic Potential ◽  
Permanent Teeth ◽  
Deciduous Teeth ◽  
Proliferative Potential ◽  
Pulp Tissue ◽  
Human Exfoliated Deciduous Teeth

: Most conventional treatments for neurodegenerative diseases fail due to their focus on neuroprotection rather than neurorestoration. Stem cell‐based therapies are becoming a potential treatment option for neurodegenerative diseases as they can home in, engraft, differentiate and produce factors for CNS recovery. Stem cells derived from human dental pulp tissue differ from other sources of mesenchymal stem cells due to their embryonic neural crest origin and neurotrophic property. These include both dental pulp stem cells [DPSCs] from dental pulp tissues of human permanent teeth and stem cells from human exfoliated deciduous teeth [SHED]. SHED offer many advantages over other types of MSCs such as good proliferative potential, minimal invasive procurement, neuronal differentiation and neurotrophic capacity, and negligible ethical concerns. The therapeutic potential of SHED is attributed to the paracrine action of extracellularly released secreted factors, specifically the secretome, of which exosomes is a key component. SHED and its conditioned media can be effective in neurodegeneration through multiple mechanisms, including cell replacement, paracrine effects, angiogenesis, synaptogenesis, immunomodulation, and apoptosis inhibition, and SHED exosomes offer an ideal refined bed-to-bench formulation in neurodegenerative disorders. However, in spite of these advantages, there are still some limitations of SHED exosome therapy, such as the effectiveness of long-term storage of SHED and their exosomes, the development of a robust GMP-grade manufacturing protocol, optimization of the route of administration, and evaluation of the efficacy and safety in humans. In this review, we have addressed the isolation, collection and properties of SHED along with its therapeutic potential on in vitro and in vivo neuronal disorder models as evident from the published literature.

scholarly journals Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson’s disease

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Junko Fujiyoshi ◽  
Haruyoshi Yamaza ◽  
Soichiro Sonoda ◽  
Ratih Yuniartha ◽  
Kenji Ihara ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wilson’S Disease ◽  
Therapeutic Potential ◽  
Wilson's Disease ◽  
Deciduous Teeth ◽  
Human Exfoliated Deciduous Teeth

scholarly journals Correction: Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0143561 ◽  
Author(s):  
Yuka Hattori ◽  
Hangsoo Kim ◽  
Naotake Tsuboi ◽  
Akihito Yamamoto ◽  
Shinichi Akiyama ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Kidney Injury ◽  
Therapeutic Potential ◽  
Kidney Injury ◽  
Deciduous Teeth ◽  
Human Exfoliated Deciduous Teeth

scholarly journals Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0140121 ◽  
Author(s):  
Yuka Hattori ◽  
Hangsoo Kim ◽  
Naotake Tsuboi ◽  
Akihito Yamamoto ◽  
Shinichi Akiyama ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Kidney Injury ◽  
Therapeutic Potential ◽  
Kidney Injury ◽  
Deciduous Teeth ◽  
Human Exfoliated Deciduous Teeth

In vitro and in vivo characteristics of stem cells from human exfoliated deciduous teeth obtained by enzymatic disaggregation and outgrowth

2014 ◽  
Vol 59 (10) ◽  
pp. 1013-1023 ◽  
Author(s):  
Mijeong Jeon ◽  
Je Seon Song ◽  
Byung-Jai Choi ◽  
Hyung-Jun Choi ◽  
Dong-Min Shin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Deciduous Teeth ◽  
Human Exfoliated Deciduous Teeth
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