scholarly journals Adherence to fecal immunochemical test screening among adults at average risk for colorectal cancer

2021 ◽  
Author(s):  
Deborah A. Fisher ◽  
Nicole Princic ◽  
Lesley-Ann Miller-Wilson ◽  
Kathleen Wilson ◽  
Kathryn DeYoung ◽  
...  
Keyword(s):  
Fecal Immunochemical Test ◽  
Administrative Claims ◽  
Average Risk ◽  
Repeat Testing ◽  
Future Studies ◽  
Increased Risk ◽  
Potential Benefits ◽  
Immunochemical Test ◽  
Alternative Test

Abstract Purpose This study examined adherence to screening for fecal immunochemical test (FIT). Methods Adults (≥ 50–75) with a FIT between 1/1/2014 and 6/30/2019 in MarketScan administrative claims were selected (index = earliest FIT). Patients were followed for 10 years pre- and 3 years post-index. Patients at increased risk for CRC or with prior screening were excluded. Year over year adherence was measured post-index. Results Of 10,253 patients, the proportion adherent to repeat testing at year 2 was 23.4% and 10.6% at year 3. Of 76.6% not adherent in year 2, 5.4% were adherent in year 3. Conclusion Results suggest adherence to FIT tests is poor, minimizing potential benefits. Future studies are needed to consider alternative test options and whether more choice will improve long-term adherence.

scholarly journals Improvement of Asia-Pacific colorectal screening score and evaluation of its use combined with fecal immunochemical test

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xu-xia He ◽  
Si-yi Yuan ◽  
Wen-bin Li ◽  
Hong Yang ◽  
Wen Ji ◽  
...  
Keyword(s):  
High Risk ◽  
Fecal Immunochemical Test ◽  
Asia Pacific ◽  
Average Risk ◽  
Predictive Values ◽  
C Statistic ◽  
Increased Risk ◽  
Immunochemical Test ◽  
Validation Set ◽  
Colorectal Screening

Abstract Background The Asia-Pacific Colorectal Screening (APCS) score is effective to screen high-risk groups of advanced colorectal neoplasia (ACN) patients but needs revising and can be combined with the fecal immunochemical test (FIT). This paper aimed to improve the APCS score and evaluate its use with the FIT in stratifying the risk of ACN. Methods This prospective and multicenter study enrolled 955 and 1201 asymptomatic Chinese participants to form the derivation and validation set, respectively. Participants received the risk factor questionnaire, colonoscopy and FIT. Multiple logistic regression was applied, and C-statistic, sensitivity and negative predictive values (NPVs) were used to compare the screening efficiency. Results A modified model was developed incorporating age, body mass index (BMI), family history, diabetes, smoking and drinking as risk factors, stratifying subjects into average risk (AR) or high risk (HR). In the validation set, the HR tier group had a 3.4-fold (95% CI 1.8–6.4) increased risk for ACN. The C-statistic for the modified score was 0.69 ± 0.04, and 0.67 ± 0.04 for the original score. The sensitivity of the modified APCS score combined with FIT for screening ACN high-risk cohorts was 76.7% compared with 36.7% of FIT alone and 70.0% of the modified APCS score alone. The NPVs of the modified score combined with FIT for ACN were 98.0% compared with 97.0% of FIT alone and 97.9% of the modified APCS score alone. Conclusions The modified score and its use with the FIT are efficient in selecting the HR group from a Chinese asymptomatic population.

The results of 3000 Fit: A prospective study led at Saint Joseph University of Beirut.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15141-e15141
Author(s):  
Ronaldo Elkaddoum ◽  
Roland Eid ◽  
Fady Haddad ◽  
Myrna Germanos ◽  
Cybel Mehawej ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Sex Ratio ◽  
Prospective Study ◽  
False Positive ◽  
Medical Genetics ◽  
Fecal Immunochemical Test ◽  
Average Risk ◽  
Intermediate Risk ◽  
Immunochemical Test ◽  
A Prospective Study

e15141 Background: In terms of frequency, colorectal cancer (CRC) is the 3rd cancer in Lebanon with 1093 incidences registered in 2015. To this date not a single screening campaign has been organized in the country. Fecal immunochemical test (FIT) is an advised screening technique. We found it useful to organize a screening campaign using FIT to determine the prevalence of CRC in a population of 3000 healthy Lebanese allowing the extraction of useful data. Methods: 3000 tubes were distributed to Lebanese adults (45-80 years old) at average risk of developing CRC, followed by explanations. FIT analysis was done at the medical genetics unit (UGM) of Saint-Joseph University and patients with positive FIT were asked to undergo further investigations. Results: Out of the 3000 distributed tests, 705 were returned (23.5%) with 459 fully analyzable. The age median was 56 (45-80). Sex ratio F/M 2.3. Out of the 459 patients, 278 (60.5%) showed 0ng/ml, 137 (29.8%) showed 1-79ng/ml, 3 (0.6%) showed 80-99ng/ml (intermediate risk values), 33 (7.1%) showed 100-800ng/ml considered as a positive value and finally 8 (1.7%) showed over range values. Among the 44 positive patients we contacted 41. Out of the 8 (18%) colonoscopies results received: 5 showed hemorrhoids leading to false positive, 1 ulcerative ileitis, 1 tubular adenomas and 1 carcinoma. Conclusions: While it was hard for us to quantify people for whom a free FIT was proposed, the low restitution rate among those who took the test shows the necessity of national screening and sensitization campaigns.

scholarly journals Usefulness of the fecal immunochemical test in the detection of advanced adenomas in subjects at average risk for colorectal cancer

Endoscopia ◽  
2015 ◽  
Vol 27 (2) ◽  
pp. 64-68 ◽  
Author(s):  
Eduardo Fenocchi ◽  
Patricia Gaggero ◽  
Mariella Rondán ◽  
Juan Carlos López-Alvarenga ◽  
Sergio Sobrino-Cossío ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fecal Immunochemical Test ◽  
Average Risk ◽  
Immunochemical Test ◽  
Advanced Adenomas

Tu1183 Fecal Immunochemical Test Accuracy for Colorectal Cancer and Significant Neoplasia Detection in Average-Risk Population

2012 ◽  
Vol 142 (5) ◽  
pp. S-768 ◽  
Author(s):  
Vicent Hernandez ◽  
Joaquin Cubiella ◽  
Carmen Gonzalez-Mao ◽  
Begoña Iglesias Rodriguez ◽  
Lucia Cid ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fecal Immunochemical Test ◽  
Test Accuracy ◽  
Average Risk ◽  
Risk Population ◽  
Immunochemical Test

Divergent Long-Term Detection Rates of Proximal and Distal Advanced Neoplasia in Fecal Immunochemical Test Screening Programs

2018 ◽  
Vol 169 (9) ◽  
pp. 602 ◽  
Author(s):  
Manuel Zorzi ◽  
Cesare Hassan ◽  
Giulia Capodaglio ◽  
Elena Narne ◽  
Anna Turrin ◽  
...  
Keyword(s):  
Fecal Immunochemical Test ◽  
Detection Rates ◽  
Screening Programs ◽  
Advanced Neoplasia ◽  
Immunochemical Test

scholarly journals Correlating Quantitative Fecal Immunochemical Test Results with Neoplastic Findings on Colonoscopy in a Population-Based Colorectal Cancer Screening Program: A Prospective Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Neal Shahidi ◽  
Laura Gentile ◽  
Lovedeep Gondara ◽  
Jeremy Hamm ◽  
Colleen E. McGahan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Screening Program ◽  
Population Based ◽  
Fecal Immunochemical Test ◽  
Average Risk ◽  
Health Authorities ◽  
Cancer Screening Program ◽  
Immunochemical Test ◽  
A Prospective Study ◽  
The Cost

Background and Aims. The Canadian Partnership Against Cancer (CPAC) recommends a fecal immunochemical test- (FIT-) positive predictive value (PPV) for all adenomas of ≥50%. We sought to assess FIT performance among average-risk participants of the British Columbia Colon Screening Program (BCCSP).Methods.From Nov-2013 to Dec-2014 consecutive participants of the BCCSP were assessed. Data was obtained from a prospectively collected database. A single quantitative FIT (NS-Plus, Alfresa Pharma Corporation, Japan) with a cut-off of ≥10 μg/g (≥50 ng/mL) was used.Results. 20,322 FIT-positive participants underwent CSPY. At a FIT cut-off of ≥10 μg/g (≥50 ng/mL) the PPV for all adenomas was 52.0%. Increasing the FIT cut-off to ≥20 μg/g (≥100 ng/mL) would increase the PPV for colorectal cancer (CRC) by 1.5% and for high-risk adenomas (HRAs) by 6.5% at a cost of missing 13.6% of CRCs and 32.4% of HRAs.Conclusions.As the NS-Plus FIT cut-off rises, the PPV for CRC and HRAs increases but at the cost of missed lesions. A cut-off of ≥10 μg/g (≥50 ng/mL) produces a PPV for all adenomas exceeding national recommendations. Health authorities need to take into consideration endoscopic resources when selecting a FIT positivity threshold.

scholarly journals Follow-up after acute Pulmonary Embolism

2018 ◽  
Vol 38 (01) ◽  
pp. 22-32 ◽  
Author(s):  
Stefano Barco ◽  
Frederikus Klok
Keyword(s):  
Pulmonary Embolism ◽  
Acute Pulmonary Embolism ◽  
Functional Limitations ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Increased Risk ◽  
Recurrent Venous Thromboembolism ◽  
Thromboembolic Pulmonary Hypertension ◽  
Potential Benefits ◽  
Definition Of

SummaryIn addition to among others major bleeding from anticoagulant therapy and recurrent venous thromboembolism (VTE), patients who survived acute pulmonary embolism (PE) face an increased risk of chronic functional limitations and decreased quality of life. In recent years, this latter complications have been better framed within the evolving definition of “post-PE syndrome” of which chronic thromboembolic pulmonary hypertension (CTEPH) represents the most extreme presentation. The post-PE syndrome in all its aspects is a frequent and clinically relevant long-term complication of PE but -except for CTEPH- has been largely understudied. There is great need to better define and understand the natural course of acute PE, to predict the development of the post-PE syndrome and to evaluate the potential benefits evolving treatments such as cardiopulmonary rehabilitation.

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