Correction to: Diagnostic value of 18F-FDG PET/CT in infective endocarditis

(1) Background: Treatment of cardiac arrhythmias and conduction disorders with the implantation of a cardiac implantable electronic device (CIED) may lead to complications. Cardiac device-related infective endocarditis (CDRIE) stands out as being one of the most challenging in terms of its diagnosis and management. Developing molecular imaging modalities may provide additional insights into CDRIE diagnosis. (2) Methods: We performed a systematic literature review to critically appraise the evidence for the diagnostic performance of the following hybrid techniques: single photon emission tomography with technetium99m-hexamethylpropyleneamine oxime–labeled autologous leukocytes (99mTc-HMPAO-SPECT/CT) and positron emission tomography with fluorodeoxyglucose (18F-FDG PET/CT). An analysis was performed in accordance with PRISMA and GRADE criteria and included articles from PubMed, Embase and Cochrane databases. (3) Results: Initially, there were 2131 records identified which had been published between 1971–2021. Finally, 18 studies were included presenting original data on the diagnostic value of 99mTc-HMPAO-SPECT/CT or 18F-FDG PET/CT in CDRIE. Analysis showed that these molecular imaging modalities provide high diagnostic accuracy and their inclusion in diagnostic criteria improves CDRIE work-up. (4) Conclusions: 99mTc-HMPAO-SPECT/CT and 18F-FDG PET/CT provide high diagnostic value in the identification of patients at risk of CDRIE and should be considered for inclusion in the CDRIE diagnostic process.

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Diagnostic value of 18F-FDG PET/CT in infective endocarditis

Clinical Research in Cardiology ◽

10.1007/s00392-021-01975-z ◽

2021 ◽

Author(s):

Vanesa Anton-Vazquez ◽

Antonio Cannata ◽

George Amin-Youssef ◽

Samuel Watson ◽

Amanda Fife ◽

...

Keyword(s):

Infective Endocarditis ◽

Fdg Pet ◽

Diagnostic Value ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Advantages of 18F-FDG PET/CT Imaging over Modified Duke Criteria and Clinical Presumption in Patients with Challenging Suspicion of Infective Endocarditis

Diagnostics ◽

10.3390/diagnostics11040720 ◽

2021 ◽

Vol 11 (4) ◽

pp. 720

Author(s):

Valentin Pretet ◽

Cyrille Blondet ◽

Yvon Ruch ◽

Matias Martinez ◽

Soraya El Ghannudi ◽

...

Keyword(s):

Infective Endocarditis ◽

Predictive Value ◽

Fdg Pet ◽

Clinical Suspicion ◽

Duke Criteria ◽

High Clinical Suspicion ◽

Pet Ct ◽

18F Fdg ◽

Sensitivity Specificity ◽

Fdg Pet Ct

According to European Society of Cardiology guidelines (ESC2015) for infective endocarditis (IE) management, modified Duke criteria (mDC) are implemented with a degree of clinical suspicion degree, leading to grades such as “possible” or “rejected” IE despite a persisting high level of clinical suspicion. Herein, we evaluate the 18F-FDG PET/CT diagnostic and therapeutic impact in IE suspicion, with emphasis on possible/rejected IE with a high clinical suspicion. Excluding cases of definite IE diagnosis, 53 patients who underwent 18F-FDG PET/CT for IE suspicion were selected and afterwards classified according to both mDC (possible IE/Duke 1, rejected IE/Duke 0) and clinical suspicion degree (high and low IE suspicion). The final status regarding IE diagnosis (gold standard) was based on the multidisciplinary decision of the Endocarditis Team, including the ‘imaging specialist’. PET/CT images of the cardiac area were qualitatively interpreted and the intensity of each focus of extra-physiologic 18F-FDG uptake was evaluated by a maximum standardized uptake value (SUVmax) measurement. Extra-cardiac 18F-FDG PET/CT pathological findings were considered to be a possible embolic event, a possible source of IE, or even a concomitant infection. Based on the Endocarditis Team consensus, final diagnosis of IE was retained in 19 (36%) patients and excluded in 34 (64%). With a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and global accuracy of 79%, 100%, 100%, 89%, and 92%, respectively, PET/CT performed significantly better than mDC (p = 0.003), clinical suspicion degree (p = 0.001), and a combination of both (p = 0.001) for IE diagnosis. In 41 patients with possible/rejected IE but high clinical suspicion, sensitivity, specificity, PPV, NPV, and global accuracies were 78%, 100%, 100%, 85%, and 90%, respectively. Moreover, PET/CT contributed to patient management in 24 out of 53 (45%) cases. 18F-FDG PET/CT represents a valuable diagnostic tool that could be proposed for challenging IE cases with significant differences between mDC and clinical suspicion degree. 18F-FDG PET/CT allows a binary diagnosis (definite or rejected IE) by removing uncertain diagnostic situations, thus improving patient therapeutic management.

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Diagnostic value of 18F-FDG PET/CT in patients with biochemical recurrent prostate cancer and negative 68Ga-PSMA PET/CT

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-021-05221-6 ◽

2021 ◽

Author(s):

Ruohua Chen ◽

Yining Wang ◽

Yiping Shi ◽

Yinjie Zhu ◽

Lian Xu ◽

...

Keyword(s):

Prostate Cancer ◽

Fdg Pet ◽

Diagnostic Value ◽

Recurrent Prostate Cancer ◽

Psma Pet ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Diagnostic value of [18F]-FDG PET/CT in children with fever of unknown origin or unexplained signs of inflammation

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-009-1185-y ◽

2009 ◽

Vol 37 (1) ◽

pp. 136-145 ◽

Cited By ~ 62

Author(s):

Niklas Jasper ◽

Jan Däbritz ◽

Michael Frosch ◽

Markus Loeffler ◽

Matthias Weckesser ◽

...

Keyword(s):

Fdg Pet ◽

Fever Of Unknown Origin ◽

Unknown Origin ◽

Diagnostic Value ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Nuclear Imaging in Infective Endocarditis

Pharmaceuticals ◽

10.3390/ph15010014 ◽

2021 ◽

Vol 15 (1) ◽

pp. 14

Author(s):

Nidaa Mikail ◽

Fabien Hyafil

Keyword(s):

Computed Tomography ◽

Infective Endocarditis ◽

Fdg Pet ◽

Imaging Techniques ◽

Nuclear Imaging ◽

Emission Tomography ◽

Cardiac Devices ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Infective endocarditis (IE) is a life-threatening disease with stable prevalence despite prophylactic, diagnostic, and therapeutic advances. In parallel to the growing number of cardiac devices implanted, the number of patients developing IE on prosthetic valves and cardiac implanted electronic device (CIED) is increasing at a rapid pace. The diagnosis of IE is particularly challenging, and currently relies on the Duke-Li modified classification, which include clinical, microbiological, and imaging criteria. While echocardiography remains the first line imaging technique, especially in native valve endocarditis, the incremental value of two nuclear imaging techniques, 18F-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG-PET/CT) and white blood cells single photon emission tomography with computed tomography (WBC-SPECT), has emerged for the management of prosthetic valve and CIED IE. In this review, we will summarize the procedures for image acquisition, discuss the role of 18F-FDG-PET/CT and WBC-SPECT imaging in different clinical situations of IE, and review the respective diagnostic performance of these nuclear imaging techniques and their integration into the diagnostic algorithm for patients with a suspicion of IE.

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Diagnostic value of 18F-FDG PET/CT for atypical hepatic hemangioma

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyab149 ◽

2021 ◽

Author(s):

Jianlin Wang ◽

Aiqi Shi ◽

Xiaofang Ding ◽

Jiangyan Liu

Keyword(s):

Fdg Pet ◽

Diagnostic Value ◽

Hepatic Hemangioma ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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333018F-Fluorodeoxyglucose Positron Emission Tomography Computed Tomography (PET/CT) for the diagnosis of prosthetic valve infective endocarditis (PVIE): a prospective multicenter study

European Heart Journal ◽

10.1093/eurheartj/ehz745.0082 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

M Philip ◽

L Tessonnier ◽

J Mancini ◽

J L Mainardi ◽

D Lussato ◽

...

Keyword(s):

Infective Endocarditis ◽

Predictive Value ◽

Fdg Pet ◽

Prosthetic Valve ◽

Cardiac Uptake ◽

Pet Ct ◽

Major Criterion ◽

18F Fdg ◽

Fdg Pet Ct

Abstract Background and objectives 18F-FDG PET/CT has recently been added as a major criterion in the ESC 2015 infective endocarditis (IE) guidelines, but the value of this new diagnostic algorithm has never been prospectively assessed. Purposes 1. Primary objective: to assess the value of the new ESC criteria including 18F-FDG PET/CT in prosthetic valve infective endocarditis (PVIE). 2. Secondary objectives: to determine the reproducibility of 18F-FDG PET/CT; to assess its ability to predict embolic events. Methods Between 2014 and 2017, 175 patients with suspected PVIE were prospectively included in 3 French centers. After exclusion of patients with uninterpretable or not feasible PET/CT,115 patients were finally included in the analysis, including 91 definite IE and 24 rejected IE, as defined by an expert Consensus of Endocarditis Team after 3-month follow-up as Gold Standard Nuclear data were blindly analyzed by two independent nuclear medicine physicians. Patients follow-up was scheduled at one and three months after hospitalization Results Significant cardiac uptake by PET/CT (major criterion) was observed in 67 among 91 patients with definite PVIE and 6 patients with rejected IE (sensitivity 73.6%, specificity 75%, positive predictive value 91%, negative predictive value 42%). Considering cardiac uptake as a major criterion, the ESC 2015 classification increased the sensitivity of Duke criteria from 57 to 84% (p<0.001) but decreased its specificity from 84 to 70% (p<0.001). Intraobserver reproducibility of cardiac uptake evaluation was good (kappa = 0.84) but inter observer reproductibility was less satisfactory (kappa = 0.63). Embolic events occurred in 31 patients (27%) and were correlated with vegetation size by ECHO (p<0.001), Staphylococcus infection (p=0.003), and PET/CT cardiac uptake (p=0.02). Conclusion 1. the value of PET CT and ESC criteria is confirmed and may allow earlier diagnosis of PVIE 2. PET CT is associated with an increased risk of false positive results probably related to the technical improvements 3. Reproducibility of nuclear measurements seems unsatisfactory, justifying efforts to standardize PET studies interpretation 4. Our study describes for the first time a positive correlation between a positive PET/Ct and occurrence of embolic events, warranting additional studies.

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