Drug delivery of sulphanilamide using modified porous calcium carbonate

AbstractChagas disease is a public health problem, affecting about 7 million people worldwide. Benznidazole (BZN) is the main treatment option, but it has limited effectiveness and can cause severe adverse effects. Drug delivery through nanoparticles has attracted the interest of the scientific community aiming to improve therapeutic options. The aim of this study was to evaluate the cytotoxicity of benznidazole-loaded calcium carbonate nanoparticles (BZN@CaCO3) on Trypanosoma cruzi strain Y. It was observed that BZN@CaCO3 was able to reduce the viability of epimastigote, trypomastigote and amastigote forms of T. cruzi with greater potency when compared with BZN. The amount of BZN necessary to obtain the same effect was up to 25 times smaller when loaded with CaCO3 nanoparticles. Also, it was observed that BZN@CaCO3 enhanced the selectivity index. Furthermore, the cell-death mechanism induced by both BZN and BZN@CaCO3 was evaluated, indicating that both substances caused necrosis and changed mitochondrial membrane potential.

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Construction of pH-responsive drug delivery platform with calcium carbonate microspheres induced by chitosan gels

Ceramics International ◽

10.1016/j.ceramint.2018.01.227 ◽

2018 ◽

Vol 44 (7) ◽

pp. 7902-7907 ◽

Cited By ~ 19

Author(s):

Jingwei Wang ◽

Yong Kong ◽

Feng Liu ◽

Dan Shou ◽

Yongxin Tao ◽

...

Keyword(s):

Drug Delivery ◽

Calcium Carbonate ◽

Ph Responsive ◽

Delivery Platform

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Application of calcium carbonate nanocarriers for controlled release of phytodrugs against Xylella fastidiosa pathogen

Pure and Applied Chemistry ◽

10.1515/pac-2018-1223 ◽

2020 ◽

Vol 92 (3) ◽

pp. 429-444 ◽

Cited By ~ 2

Author(s):

Francesca Baldassarre ◽

Angelo De Stradis ◽

Giuseppe Altamura ◽

Viviana Vergaro ◽

Cinzia Citti ◽

...

Keyword(s):

Drug Delivery ◽

Calcium Carbonate ◽

Controlled Release ◽

Drug Delivery Systems ◽

Xylella Fastidiosa ◽

Delivery Systems ◽

In Planta ◽

Potential Control ◽

Antimicrobial Substances ◽

Olive Quick Decline Syndrome

AbstractCalcium carbonate-based hollow or porous particles are one of the preferred carriers for fabrication of drug delivery systems. We have developed an eco-friendly method to produce calcium carbonate nanocrystals, which have shown biocompatibility and optimal capacity to across cell membrane in human cell lines providing new tools in cancer therapy. The success of drug delivery systems has paved the way for the development of systems for controlled release of agrochemicals. In this work, we exploited calcium carbonate nanocrystals as carriers for targeted release of phytodrugs investigating a potential control strategy for the pathogen Xylella fastidiosa. This pathogen is the causal agent of the Olive Quick Decline Syndrome that is an unprecedented emergency in Italy and potentially in the rest of Europe. We studied nanocrystals interactions with bacteria cells and the application in planta to verify olive plants uptake. Ultrastructural analysis by electron microscopy shown an alteration of bacteria wall following nanocrystals interaction. Nanocrystals were adsorbed from roots and they translocated in plants tissues. Calcium carbonate carriers were able to encapsulate efficiently two types of antimicrobial substances and the potential efficacy was tested in experiment under greenhouse conditions.

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