Synthesis of calcium carbonate nanocrystals and their potential application as vessels for drug delivery

2015 ◽  
Author(s):  
Viviana Vergaro ◽  
Elisabetta Carata ◽  
Elisa Panzarini ◽  
Francesca Baldassare ◽  
Luciana Dini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Carbonate ◽  
Potential Application

Synthesis of PMMA-b-PS Block Copolymer by Emulsion ATRP and its Self-Assembly Property

2013 ◽  
Vol 705 ◽  
pp. 115-119
Author(s):  
Bao Yong Tian ◽  
Er Jun Tang ◽  
Miao Yuan ◽  
Rui Xia Hao ◽  
Cun Man Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Self Assembly ◽  
Potential Application ◽  
Morphological Characteristic ◽  
Living Polymerization ◽  
The Self ◽  
Emulsion System ◽  
Copolymer Concentration ◽  
Ft Ir

The well-defined block copolymer PMMA-b-PS was prepared by two-step ATRP in emulsion system. GPC results indicate that Mn increased linearly with conversion and polydispersity remained relatively narrow. It presents the characteristics of living polymerization in emulsion system. FT-IR demonstrated that block copolymer PMMA-b-PS could be successfully synthesized by ATRP with macroinitiator PMMA-Cl in emulsion system. The morphological characteristic of the self-assembly depends on the block copolymer concentration and transforms between spheres and rodlike micelles. The property indicates a perfect potential application in drug delivery materials.

scholarly journals Synthesis and characterization of perfluoro-tert-butyl semifluorinated amphiphilic polymers and their potential application in hydrophobic drug delivery

2014 ◽  
Vol 5 (22) ◽  
pp. 6461-6471 ◽  
Author(s):  
Sarah Decato ◽  
Troy Bemis ◽  
Eric Madsen ◽  
Sandro Mecozzi
Keyword(s):  
Drug Delivery ◽  
Potential Application ◽  
Amphiphilic Polymers ◽  
Synthesis And Characterization ◽  
Hydrophobic Drug ◽  
Tert Butyl ◽  
Theranostic Applications ◽  
Polymer Surfactants

Semifluorinated polymer surfactants containing one, two, or three perfluoro-tert-butyl groups were synthesized and fully characterized. Theranostic applications are discussed.

Degradable Nanomotors Using Platinum Deposited Complex of Calcium Carbonate and Hyaluronate Nanogels for Targeted Drug Delivery

2019 ◽  
Vol 37 (1) ◽  
pp. 1900418 ◽  
Author(s):  
Hyunsik Choi ◽  
Byung Woo Hwang ◽  
Kyeng Min Park ◽  
Ki Su Kim ◽  
Sei Kwang Hahn
Keyword(s):  
Drug Delivery ◽  
Calcium Carbonate ◽  
Targeted Drug Delivery ◽  
Targeted Drug

Nanoencapsulation of benznidazole in calcium carbonate increases its selectivity to Trypanosoma cruzi

Parasitology ◽  
2018 ◽  
Vol 145 (9) ◽  
pp. 1191-1198 ◽  
Author(s):  
Louise Donadello Tessarolo ◽  
Ramon Róseo Paula Pessoa Bezerra de Menezes ◽  
Clarissa Perdigão Mello ◽  
Dânya Bandeira Lima ◽  
Emanuel Paula Magalhães ◽  
...  
Keyword(s):  
Public Health ◽  
Drug Delivery ◽  
Cell Death ◽  
Calcium Carbonate ◽  
Trypanosoma Cruzi ◽  
Mitochondrial Membrane ◽  
Scientific Community ◽  
Public Health Problem ◽  
Selectivity Index ◽  
Limited Effectiveness

AbstractChagas disease is a public health problem, affecting about 7 million people worldwide. Benznidazole (BZN) is the main treatment option, but it has limited effectiveness and can cause severe adverse effects. Drug delivery through nanoparticles has attracted the interest of the scientific community aiming to improve therapeutic options. The aim of this study was to evaluate the cytotoxicity of benznidazole-loaded calcium carbonate nanoparticles (BZN@CaCO3) on Trypanosoma cruzi strain Y. It was observed that BZN@CaCO3 was able to reduce the viability of epimastigote, trypomastigote and amastigote forms of T. cruzi with greater potency when compared with BZN. The amount of BZN necessary to obtain the same effect was up to 25 times smaller when loaded with CaCO3 nanoparticles. Also, it was observed that BZN@CaCO3 enhanced the selectivity index. Furthermore, the cell-death mechanism induced by both BZN and BZN@CaCO3 was evaluated, indicating that both substances caused necrosis and changed mitochondrial membrane potential.

A Tunable pH-Responsive Nanomaterials for Cancer Delivery

2013 ◽  
Vol 750-752 ◽  
pp. 1476-1479 ◽  
Author(s):  
Bin Liu ◽  
Guan Hui Gao ◽  
Peng Liu ◽  
Hu Qiang Yi ◽  
Wei Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Potential Application ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Positive Potential ◽  
Ph Values ◽  
Drugs In Blood ◽  
Poly Ethylene

In this paper, we successfully designed a pH-responsive micelles based on hybrid polypeptide copolymers of poly (L-lysine-4-Azepan-1-yl-butyric)-b-poly (ethylene glycol)-b-poly (L-lysine-Diisopropylamide)-b-poly (L-leucine) (PLL(A)-PEG-PLL(B)-PLLeu) for efficient drug delivery. This pH-responsive nanoparticles were able to response to different pH values (pH=6.8 and 5.5). In vitro, these nanoparticles exhibited a stable and evenly distributed approximately 51 nm, a slightly positive potential about 10.3 mv at pH 7.4, which were crucial for the circulation of drugs in blood. While size and potential were about 130 nm and 34.7 mv at pH 6.8, which were good for drugs in membrane. Furthermore, the loading capability of DOX was up to 11.3%, and the pH-responsive release efficiency reached to 68.3% at pH 5.5. The results indicated that these micelles had huge potential application in cancer delivery.

Hierarchically Nanostructured Magnetic Hollow Spheres of Fe3O4and γ-Fe2O3:  Preparation and Potential Application in Drug Delivery

2008 ◽  
Vol 112 (6) ◽  
pp. 1851-1856 ◽  
Author(s):  
Shao-Wen Cao ◽  
Ying-Jie Zhu ◽  
Ming-Yan Ma ◽  
Liang Li ◽  
Ling Zhang
Keyword(s):  
Drug Delivery ◽  
Potential Application ◽  
Hollow Spheres

Construction of pH-responsive drug delivery platform with calcium carbonate microspheres induced by chitosan gels

2018 ◽  
Vol 44 (7) ◽  
pp. 7902-7907 ◽  
Author(s):  
Jingwei Wang ◽  
Yong Kong ◽  
Feng Liu ◽  
Dan Shou ◽  
Yongxin Tao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Carbonate ◽  
Ph Responsive ◽  
Delivery Platform
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