Damping function for narrow and large molecular weight polymers: comparison with the force-balanced network model

2005 ◽  
Vol 44 (4) ◽  
pp. 372-378 ◽  
Author(s):  
Mustapha Iza ◽  
Mosto Bousmina
Keyword(s):  
Molecular Weight ◽  
Network Model ◽  
Damping Function ◽  
Large Molecular Weight ◽  
Balanced Network

The External Shape of Human γ GI Immunoglobulin from Crystal Sections

1971 ◽  
Vol 29 ◽  
pp. 428-429
Author(s):  
L. W. Labaw
Keyword(s):  
Molecular Weight ◽  
Sodium Phosphate ◽  
Osmium Tetroxide ◽  
Unit Cell ◽  
Monoclinic Space Group ◽  
X Ray ◽  
Large Molecular Weight ◽  
Cell Dimensions ◽  
Unit Cell Dimensions ◽  
Crystallographic Axes

Crystals of a human γGl immunoglobulin have the external morphology of diamond shaped prisms. X-ray studies have shown them to be monoclinic, space group C2, with 2 molecules per unit cell. The unit cell dimensions are a = 194.1, b = 91.7, c = 51.6Å, 8 = 102°. The relatively large molecular weight of 151,000 and these unit cell dimensions made this a promising crystal to study in the EM.Crystals similar to those used in the x-ray studies were fixed at 5°C for three weeks in a solution of mother liquor containing 5 x 10-5M sodium phosphate, pH 7.0, and 0.03% glutaraldehyde. They were postfixed with 1% osmium tetroxide for 15 min. and embedded in Maraglas the usual way. Sections were cut perpendicular to the three crystallographic axes. Such a section cut with its plane perpendicular to the z direction is shown in Fig. 1.This projection of the crystal in the z direction shows periodicities in at least four different directions but these are only seen clearly by sighting obliquely along the micrograph.

scholarly journals Association of large molecular weight proteasome 7 gene polymorphism with ankylosing spondylitis

1998 ◽  
Vol 41 (3) ◽  
pp. 560-562 ◽  
Author(s):  
A. Fraile ◽  
A. Nieto ◽  
J. Vinasco ◽  
Y. Bera�n ◽  
J. Mart�n ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Ankylosing Spondylitis ◽  
Gene Polymorphism ◽  
Large Molecular Weight

scholarly journals Detection and isolation of inactive, large molecular weight renin in human kidney and plasma.

Hypertension ◽  
1981 ◽  
Vol 3 (3_pt_2) ◽  
Author(s):  
S A Atlas ◽  
J E Sealey ◽  
B Dharmgrongartama ◽  
T E Hesson ◽  
J H Laragh
Keyword(s):  
Molecular Weight ◽  
Human Kidney ◽  
Large Molecular Weight

Biliary obstruction dissipates bioelectric sinusoidal-canalicular barrier without altering taurocholate uptake

1989 ◽  
Vol 256 (2) ◽  
pp. G312-G318
Author(s):  
J. Cotting ◽  
T. Zysset ◽  
J. Reichen
Keyword(s):  
Molecular Weight ◽  
Biliary Obstruction ◽  
Molecular Size ◽  
Base Line ◽  
Hepatic Extraction ◽  
Short Term ◽  
Extrahepatic Cholestasis ◽  
Large Molecular Weight ◽  
Unidirectional Transfer

To study immediate events during extrahepatic cholestasis, we investigated the effect of short-term biliary obstruction on the bioelectrical sinusoidal-canalicular barrier in the rat using molecular weight-matched uncharged and negatively charged inert solute pairs. The bioelectrical barrier averaged -22 +/- 5 and -18 +/- 4 mV (NS) using the pair carboxy-/methoxyinulin and ferrocyanide/sucrose, respectively. After a 20-min biliary obstruction both decreased by 61 and 11%, respectively, but only the large molecular weight pair (the inulins) returned to base line after release of the obstruction. Inert solute clearances were increased after short biliary obstruction depending on molecular size and negative charge (ferrocyanide greater than sucrose greater than carboxyinulin greater than inulin), suggesting that both permeability and bioelectrical barriers were affected by obstruction. The hepatic extraction in vivo of a passively transported drug not excreted into bile (D-propranolol) was not affected by obstruction, whereas that of an actively transported drug (glycocholate) decreased from 66 +/- 8 to 41 +/- 20% during biliary obstruction (P less than 0.01). Unidirectional transfer of glycocholate was not affected by short-term biliary obstruction in the situ perfused rat liver; however, 2 min after [14C]glycocholate administration, increased return was observed in hepatic venous effluent in obstructed animals. Our findings demonstrate a loss of the bioelectrical barrier immediately after short-term biliary obstruction. Decreased hepatic extraction in the view of unaltered sinusoidal uptake demonstrates regurgitation of bile into blood during short-term biliary obstruction.

Sign in / Sign up

Export Citation Format

Share Document