Changes of D-dimer after total hip arthroplasty in patients with and without intraoperative heparin

2007 ◽  
Vol 128 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Katsuhiko Maezawa ◽  
Masahiko Nozawa ◽  
Kentaro Aritomi ◽  
Mitsuaki Kubota ◽  
Katsuo Shitoto ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Total Hip ◽  
D Dimer

scholarly journals Does Prophylactic Administration of Edoxaban Increase D-Dimer Levels after Total Hip Arthroplasty?

2019 ◽  
Vol 8 (5) ◽  
pp. 678 ◽  
Author(s):  
Toshiyuki Kawai ◽  
Yutaka Kuroda ◽  
Koji Goto ◽  
Shuichi Matsuda
Keyword(s):  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Multivariate Regression ◽  
Multivariate Regression Analysis ◽  
Regression Analyses ◽  
Independent Variables ◽  
Total Hip ◽  
Clinically Important Difference ◽  
Duration Of Surgery ◽  
D Dimer

This study aimed to examine the effect of thromboprophylactic edoxaban on D-dimer levels and anemia after total hip arthroplasty (THA). We retrospectively analyzed data from 349 patients undergoing primary THA. Univariate regression and multivariate regression analyses were performed with D-dimer levels on the 7th, 14th, and 21st days postoperatively as the dependent variable Edoxaban use, age, sex, body mass index (BMI), renal function, drop in hemoglobin (Hb) drop, intraoperative blood loss and duration of surgery as were independent variables. Multivariate regression analysis was also performed with Hb drop as the dependent variable. Edoxaban administration of 15 mg/day and 30 mg/day after THA was correlated with higher D-dimer levels at 21, but not at 7 or 14, days postoperatively. Other significant independent predictors for high D-dimer levels were the duration of surgery (at 7 and 14 days), BMI (at 7 days), sex (at 14 days), and age (at 14 and 21 days). Edoxaban use was significantly, weakly correlated with a larger Hb drop at 7 and 14 days, but this was less than a clinically important difference. D-dimer levels after THA can be elevated by thromboprophylactic edoxaban after three weeks postoperatively.

Deep vein thrombosis after total hip arthroplasty in Korean patients and D-dimer as a screening tool

2008 ◽  
Vol 129 (7) ◽  
pp. 887-894 ◽  
Author(s):  
Myung-Chul Yoo ◽  
Yoon-Je Cho ◽  
Elie Ghanem ◽  
Alankar Ramteke ◽  
Kang-Il Kim
Keyword(s):  
Deep Vein Thrombosis ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Screening Tool ◽  
Total Hip ◽  
Korean Patients ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
D Dimer

scholarly journals Usefulness of a novel method for the screening of deep vein thrombosis by using a combined D-dimer- and age-based index before total hip arthroplasty

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0172849 ◽  
Author(s):  
Norio Imai ◽  
Dai Miyasaka ◽  
Hayato Shimada ◽  
Ken Suda ◽  
Tomoyuki Ito ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Total Hip ◽  
Vein Thrombosis ◽  
Novel Method ◽  
Deep Vein ◽  
D Dimer

scholarly journals Comparison of the incidence of venous thromboembolism with minimally invasive total hip arthroplasty: a case control study

2020 ◽  
Author(s):  
Toru Nishiwaki ◽  
Akihito Oya ◽  
Arihiko Kanaji
Keyword(s):  
Venous Thromboembolism ◽  
Total Hip Arthroplasty ◽  
Minimally Invasive ◽  
Hip Arthroplasty ◽  
Surgical Approach ◽  
Operative Time ◽  
Anterolateral Approach ◽  
Multidetector Row Computed Tomography ◽  
Total Hip ◽  
D Dimer

Abstract Background: Venous thromboembolism (VTE) remains a major complication after total hip arthroplasty (THA), irrespective of the surgical approach. This study investigated the incidence of VTE in patients undergoing THA through intermuscular minimally invasive surgical techniques, which included a direct anterior approach (DAA), an anterolateral approach (AL), and anterolateral supine approach (ALS), at a single institution. Methods: One hundred consecutive patients treated with each surgical approach were evaluated. Plasma D-dimer levels 1 month preoperatively and 1 day postoperatively, operative time, and intraoperative blood loss were recorded, and the presence of VTE was evaluated based on multidetector row computed tomography performed the day after surgery. Student’s t-test and Pearson’s chi-square test or one-way analysis of variance were used in statistical analysis. Results: No differences among the groups in terms of age, height, weight, operative time, intraoperative bleeding, and preoperative and postoperative D-dimer levels were observed. The overall incidence of VTE was 21%. The incidences of VTE were 30% in AL, 17% in ALS, and 16% in DAA, representing a significantly higher rate in AL than in ALS and DAA (P=0.025). The incidences of VTE on the operated side were 19% in AL, 13% in ALS, and 12% in DAA, with no statistically significant differences. The incidences of VTE on the non-operated side were 22% in AL, 9% in ALS, and 8% in DAA; these differences were statistically significant (P=0.0045). Conclusions: Results showed that the incidence of VTE was significantly higher in AL than in ALS and DAA, especially for the non-operated side.

scholarly journals Periarticular Analgesic Injection Containing A Corticosteroid Reduces D-Dimer Levels After Total Hip Arthroplasty: Retrospective Comparative Cohort Study

2020 ◽  
Author(s):  
Akira Hashimoto ◽  
Motoki Sonohata ◽  
Hirohito Hirata ◽  
Shunsuke Kawano ◽  
Shuichi Eto ◽  
...  
Keyword(s):  
Cohort Study ◽  
Total Hip Arthroplasty ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Hip Arthroplasty ◽  
Control Group ◽  
Systemic Effects ◽  
Early Ambulation ◽  
Total Hip ◽  
D Dimer

Abstract Background: Of late, periarticular analgesic injection (PAI) has become a common alternative treatment for pain following total hip arthroplasty (THA). However, the systemic effects of PAI containing corticosteroids in patients subjected to THA have not been investigated. This study evaluated the analgesic efficacy and systemic effects of PAI containing a corticosteroid in patients subjected to THA. Methods: This single-center, retrospective cohort study enrolled patients undergoing unilateral, primary THA. A total of 197 patients (200 hips) were included in the final analyses, with 87 hips in the PAI group and 113 hips in the control group. Numeric Rating Scale (NRS) and laboratory data were assessed preoperatively and on postoperative days (POD) 1 and 7. Pearson’s correlation coefficients were obtained to assess the correlations between the D-dimer level on POD 7 and each outcome measure on POD 1. Results: The postoperative white blood cell count (WBC) was significantly higher in the PAI group than in the control group. Postoperative NRS, creatine phosphokinase (CK), and C-reactive protein (CRP) levels were significantly lower in the PAI group. D-dimer levels were significantly lower in the PAI group on POD 7. Postoperative aspartate transaminase (AST), alanine aminotransferase, blood urea nitrogen, and creatinine levels were within reference ranges. D-dimer levels on POD 7 showed a significant negative correlation with WBC on POD 1 (r=-0.4652) and a significant positive correlation with the NRS score and AST, CK, CRP, and D-dimer levels on POD 1 (r=0.1558, 0.2353, 0.2718, 0.3545, and 0.3359, respectively).Conclusions: PAI containing a corticosteroid may be an effective treatment for pain and inflammation after THA, and it does not seem to cause drug-induced liver or kidney injury. Moreover, corticosteroid PAI can reduce D-dimer levels, which are associated with deep venous thrombosis. Early ambulation may prevent the elevation of postoperative D-dimer levels, and PAI containing a corticosteroid may accelerate early ambulation and reduce the risk of deep venous thrombosis.

scholarly journals Periarticular analgesic injection containing a corticosteroid after total hip arthroplasty may prevent deep venous thrombosis: a retrospective comparative cohort study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Akira Hashimoto ◽  
Motoki Sonohata ◽  
Hirohito Hirata ◽  
Shunsuke Kawano ◽  
Shuichi Eto ◽  
...  
Keyword(s):  
Cohort Study ◽  
Total Hip Arthroplasty ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Hip Arthroplasty ◽  
Control Group ◽  
Systemic Effects ◽  
Reference Ranges ◽  
Total Hip ◽  
D Dimer

Abstract Background Of late, periarticular analgesic injection (PAI) has become a common alternative treatment for pain following total hip arthroplasty (THA). However, the systemic effects of PAI containing corticosteroids in patients subjected to THA have not been investigated. This study evaluated the analgesic efficacy and systemic effects of PAI containing a corticosteroid in patients subjected to THA. Methods This single-center, retrospective cohort study enrolled patients undergoing unilateral, primary THA. A total of 197 patients (200 hips) were included in the final analyses, with 87 hips in the PAI group and 113 hips in the control group. Numeric Rating Scale (NRS) and laboratory data were assessed preoperatively and on postoperative days (POD) 1 and 7. Pearson’s correlation coefficients were obtained to assess the correlations between the D-dimer level on POD 7 and each outcome measure on POD 1. Results The postoperative white blood cell count (WBC) was significantly higher in the PAI group than in the control group. Postoperative NRS, creatine phosphokinase (CK), and C-reactive protein (CRP) levels were significantly lower in the PAI group. D-dimer levels were significantly lower in the PAI group on POD 7. Postoperative aspartate transaminase (AST), alanine aminotransferase, blood urea nitrogen, and creatinine levels were within reference ranges. D-dimer levels on POD 7 showed a significant negative correlation with WBC on POD 1 (r=-0.4652) and a significant positive correlation with the NRS score and AST, CK, CRP, and D-dimer levels on POD 1 (r = 0.1558, 0.2353, 0.2718, 0.3545, and 0.3359, respectively). Conclusions PAI containing a corticosteroid may be an effective treatment for pain and inflammation after THA, and it does not seem to cause drug-induced liver or kidney injury. Moreover, corticosteroid PAI can may accelerate early ambulation, which prevents the elevation of postoperative D-dimer levels, and may reduce the risk of deep venous thrombosis.

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