Evidence of proliferative activity in human Merkel cells: implications in the histogenesis of Merkel cell carcinoma

2018 ◽  
Vol 311 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Yutaka Narisawa ◽  
Takuya Inoue ◽  
Kotaro Nagase
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Proliferative Activity ◽  
Merkel Cells ◽  
Merkel Cell

Metastasis of cancer from Merkel cells to the thyroid gland

2021 ◽  
Vol 19 (1) ◽  
pp. 86-88
Author(s):  
Piotr Przyczyna ◽  
◽  
Elżbieta Trojnar ◽  
Dorota Bartusik-Aebisher ◽  
David Aebisher ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Thyroid Cancer ◽  
Thyroid Gland ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Uterine Fibroids ◽  
Degenerative Changes ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Left Buttock

Introduction. Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer. Aim. Herein described is a case of hypertensive patient, after removal of Merkel cancer of the left gluteus skin (2011), after pulmonary embolism (2013), with degenerative changes of the spine and uterine myoma, chronically treated with Warfarin, because of suspected thyroid cancer. Description of the case. A 70-year-old woman case after removing Merkel cancer of the left buttock skin (2011), after pulmonary embolism (2013), with degenerative changes of the spine and uterine fibroids treated chronically with Warfarin because of suspected thyroid cancer is described. Conclusion. Increasing evidence of Merkel cell carcinoma with immunodeficiency and neoplasia, and the management and outcome of these patients requires study.

scholarly journals Which Are the Cells of Origin in Merkel Cell Carcinoma?

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Thomas Tilling ◽  
Ingrid Moll
Keyword(s):  
Risk Factors ◽  
Stem Cells ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Neuroendocrine Cells ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Skin Tumour ◽  
Future Studies ◽  
Cells Of Origin

Merkel cell carcinoma (MCC), a highly aggressive skin tumour with increasing incidence, is associated with the newly discovered Merkel cell polyomavirus (MCPyV). Studies on MCC and MCPyV as well as other risk factors have significantly increased our knowledge of MCC pathogenesis, but the cells of origin, which could be important targets in future therapies, are still unknown. Merkel cells (MCs), the neuroendocrine cells of the skin, were believed to be at the origin of MCC due to their phenotypic similarities. However, for several reasons, for example, heterogeneous differentiation of MCCs and postmitotic character of MCs, it is not very likely that MCC develops from differentiated MCs. Skin stem cells, probably from the epidermal lineage, are more likely to be cells of origin in MCC. Future studies will have to address these questions more directly in order to identify the physiological cells which are transformed to MCC cells.

scholarly journals 61-Year-Old White Female with a Non-Healing Ulcerated Ankle Mass

2019 ◽  
Vol 3 (5) ◽  
pp. 344-347
Author(s):  
Christopher Lowther ◽  
Troy Fiddler ◽  
Ian A Whitcroft ◽  
Juanita Sapp ◽  
Etan Marks ◽  
...  
Keyword(s):  
Complete Remission ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Merkel Cell Carcinoma ◽  
Tumor Response ◽  
Polyoma Virus ◽  
White Female ◽  
Merkel Cells ◽  
Merkel Cell ◽  
One Year

Merkel cell carcinoma is a  rare cutaneous carcinoma from the tactile Merkel cells. With fewer than half the patients surviving more than one year and fewer than 20% surviving beyond five years. These tumors are rarely suspected until the biopsy results return. Polyoma virus is associated with up to 80% of the tumors. 53% present on the head and neck and 35% present on the extremities while larger lesions are exceedingly rare in either location. Recently, A newly approved drug, Avelumab, has shown tumor response in patients with some patients experiencing complete remission.

scholarly journals Merkel Cell Polyomavirus and Merkel Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1774 ◽  
Author(s):  
Valeria Pietropaolo ◽  
Carla Prezioso ◽  
Ugo Moens
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Human Tumor ◽  
Merkel Cell Polyomavirus ◽  
Cell Tropism ◽  
Merkel Cells ◽  
Merkel Cell ◽  
Tumor Viruses ◽  
Cells Of Origin ◽  
Rna And Dna

Viruses are the cause of approximately 15% of all human cancers. Both RNA and DNA human tumor viruses have been identified, with Merkel cell polyomavirus being the most recent one to be linked to cancer. This virus is associated with about 80% of Merkel cell carcinomas, a rare, but aggressive cutaneous malignancy. Despite its name, the cells of origin of this tumor may not be Merkel cells. This review provides an update on the structure and life cycle, cell tropism and epidemiology of the virus and its oncogenic properties. Putative strategies to prevent viral infection or treat virus-positive Merkel cell carcinoma patients are discussed.

Merkel cell carcinoma of the skin: the structure and origin of normal Merkel cells

1983 ◽  
Vol 7 (2) ◽  
pp. 229-249 ◽  
Author(s):  
B. FRIGERIO ◽  
C. CAPELLA ◽  
V. EUSEB ◽  
P. TENTI ◽  
J. G. AZZOPARDI
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cells ◽  
Merkel Cell

scholarly journals Comparative transcriptional profiling of human Merkel cells and Merkel cell carcinoma

2014 ◽  
Vol 23 (12) ◽  
pp. 928-930 ◽  
Author(s):  
Nicolas Mouchet ◽  
Nolwenn Coquart ◽  
Nicolas Lebonvallet ◽  
Christelle Le Gall-Ianotto ◽  
Ariane Mogha ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Transcriptional Profiling ◽  
Merkel Cells ◽  
Merkel Cell

Proliferative activity detected by Ki67 correlates with poor outcome in Merkel cell carcinoma

2006 ◽  
Vol 49 (5) ◽  
pp. 551-553 ◽  
Author(s):  
V Koljonen ◽  
E Tukiainen ◽  
C Haglund ◽  
T Böhling
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Proliferative Activity ◽  
Merkel Cell ◽  
Poor Outcome

Merkel cells and Merkel cell carcinoma express the BCL-2 proto-oncogene

1996 ◽  
Vol 5 (3) ◽  
pp. 183-188 ◽  
Author(s):  
Andreas Plettenberg ◽  
Johannes Pammer ◽  
Enwin Tschachler
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cells ◽  
Merkel Cell
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