Effectiveness of expectant management versus methotrexate in tubal ectopic pregnancy: a double-blind randomized trial

2014 ◽  
Vol 291 (4) ◽  
pp. 939-943 ◽  
Author(s):  
Priscila Matthiesen Silva ◽  
Edward Araujo Júnior ◽  
Gustavo Nardini Cecchino ◽  
Julio Elito Júnior ◽  
Luiz Camano
Author(s):  
Anjali Choudhary ◽  
Priyanka Chaudhari ◽  
Neeta Bansal

Background: Ectopic pregnancy is still the leading cause of pregnancy related morbidity in the first trimester. Since majority of the women who present with ectopic pregnancies are sub fertile and young, there is a role for non-surgical options of managing these pregnancies. Expectant and medical management not only serves to conserve the fallopian tubes but also saves women from surgical trauma and morbidity. The objective of this retrospective study was to share our experience of treating un-ruptured tubal ectopic pregnancies conservatively.Methods: Women diagnosed with un-ruptured tubal ectopic pregnancy, fit for conservative /medical management were included. Women with serum beta HCG levels less than 1000 mIU/L were treated expectantly and women with Bet HCG levels >1000 but <10,000 mIU /L were given Injectable methotrixate. Response to treatment was monitored by serial beta HCG levels.Results: Total 37 women included in the study.12% women showed complete resolution with expectant treatment alone and 88% resolved after a single dose methotrixate.Conclusions: Many women with un-ruptured tubal ectopic pregnancies would benefit from expectant management, or methotrixate therapy. Methotrixate used in carefully selected women is safe and effective in resolving these cases with good post treatment reproductive outcome.


2019 ◽  
Vol 12 (12) ◽  
pp. e230876
Author(s):  
Amenda Ann Davis ◽  
Kusum Lata ◽  
Akshita Panwar ◽  
Alka Kriplani

Expectant management of tubal ectopic pregnancies is a feasible and possibly preferable method of management in asymptomatic women with low serum β-human chorionic gonadotropin (hCG). This involves serial monitoring of β-hCG until negative, after which it is deemed as spontaneously resolved ectopic pregnancy. We describe a case of tubal ectopic pregnancy which was expectantly managed with an initial β-hCG of 585 mIU/mL until undetectable. This patient presented with ruptured ectopic pregnancy 8 weeks after the original diagnosis, at the level of 5 mIU/mL. This highlights the importance of close monitoring in the expectant management of tubal ectopic pregnancies, with the incorporation of imaging, even when serial β-hCG shows a persistently reducing trend.


2019 ◽  
Vol 2 (2) ◽  
pp. 38-39
Author(s):  
Agus Cakhantara ◽  
Aditya Prabawa

Objective : To compare treatment in ectopic pregnancy within combination gefitinib, methotrexat and methotrexat only Method : Literature Review Result : Ectopic pregnancies are serious condition that can be fatal, therefore the prompt therapeutic is essential. There some recent studies explain molecular target therapeutic use combination of gefitinib and methotrexat is more effective inducing placental cell death and can rapidly resolve tubal ectopic pregnancy than methotrexate only. If a large clinical randomized trial confirm these finding, these combination could become a new medical option for ectopic pregnancy Conclusion : Combination gefitinib and methotrexate is more effective in ectopic pregnancy than methotrexate only


Sign in / Sign up

Export Citation Format

Share Document