scholarly journals Photodynamic therapy of early stage oral cavity and oropharynx neoplasms: an outcome analysis of 170 patients

2010 ◽  
Vol 268 (2) ◽  
pp. 281-288 ◽  
Author(s):  
Baris Karakullukcu ◽  
Kim van Oudenaarde ◽  
Marcel P. Copper ◽  
W. M. C. Klop ◽  
Robert van Veen ◽  
...  
2012 ◽  
Vol 270 (3) ◽  
pp. 1093-1097 ◽  
Author(s):  
Baris Karakullukcu ◽  
Sharon D. Stoker ◽  
Anne P. E. Wildeman ◽  
Marcel P. Copper ◽  
Maarten A. Wildeman ◽  
...  

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P34-P34
Author(s):  
Vanessa G Schweitzer ◽  
Melissa L Somers

Objective To evaluate the efficacy of PHOTOFRIN-mediated photodynamic therapy (PDT) for treatment of diffuse ‘field cancerization’ and Tis-T2N0M0 squamous cell carcinoma (SqCCa) of the oral cavity and oral pharynx in patients not amenable to or that failed conventional head and neck treatment. Methods This is nonrandomized prospective study of 28 patients with field cancerization and early stage Tis-T2N0M0 squamous cell carcinoma of the oral cavity/oropharynx treated with PHOTOFRIN-mediated PDT. Intravenous PHOTOFRIN (porfimer sodium)(dose 2.0 mg/kg) was administered outpatient, followed 48–60 hours later by intraoperative photoactivation at 630nm via fiberoptic microlens surface delivery (surgical light dose 50–100 J/cm2). Results 21 of 27 patients (77%) have demonstrated complete remission (follow-up 1 month to 12 years). There were 5 patients that had partial remission with recurrence observed at 3, 3, 8, 22, and 23 months subsequently retreated with conventional therapy. All locally disease-free individuals were followed up between 1 to 144 months. 14 of the 21 patients in complete remission were disease-free for a period greater than 1 year following photodynamic therapy. Conclusions PHOTOFRIN-mediated photodynamic therapy can be used as a primary modality to treat Tis-T2N0 tumors of the oral cavity and oropharynx or for treatment for those that have failed prior surgery and/or radiation therapy. PDT allows for preservation of function and structure with absence of systemic toxicity, and patients may have multiple drug administrations and laser light retreatments for local disease control.


2012 ◽  
Vol 153 (45) ◽  
pp. 1779-1786 ◽  
Author(s):  
Mária Resch ◽  
Ágnes Nagy

Since the 1990s numerous international experts have reported about the somatic complications of eating disorders including those having a dental and stomatological nature. Several reports emphasised that deformations in the oral cavity resulting from this grave nutritional disease typical of the young generation could already appear in the early stage and, therefore, dentists are among the first to diagnose them. Dentists are still often unaware of the importance of their role in multidisciplinary treatment. Even if they knew what the disease was about and recognised it on the basis of deformations in the oral cavity in time, their advice that their patients should brush their teeth more often would fail to eliminate the root cause of the problem. Not only the earliest possible treatment of the complications of the bingeing-purging mechanism and the maintenance of oral hygiene are important, but controlling and curing pathological habits with active participation of psychiatrists are also required to ensure full recovery. Due to the multidisciplinary nature of the disease, manifold communication is required. For this reason, publishing the dental ramifications of organic and systemic diseases at dental conferences and in technical journals, as well as providing information about oral complications of eating disorders for general practitioners and specialists are particularly important. Orv. Hetil., 2012, 153, 1779–1786.


Author(s):  
Peiru Wang ◽  
Guolong Zhang ◽  
Linglin Zhang ◽  
Zhongxia Zhou ◽  
Lei Shi ◽  
...  

1996 ◽  
Vol 2 (4) ◽  
pp. 203-206 ◽  
Author(s):  
Tetsuya Okunaka ◽  
Harubumi Kato ◽  
Chimori Konaka ◽  
Kinya Furukawa ◽  
Masahiko Harada ◽  
...  

Photodynamic therapy (PDT) utilizing Photofrin is proving to be effective for the treatment of early stage lung cancer. However, wider clinical applications of Photofrin as a photosensitizer for various cancers are hampered by potentially serious and prolonged skin photosensitivity. To prevent these side effects and reduce the hospitalization period, we recently gave reduced doses of Photofrin by bronchial arterial infusion. Five patients with endoscopically evaluated minimally invasive carcinoma of the lung were given 0.7 mg/kg of Photofrin by bronchial arterial infusion 48 hr before PDT. Complete remission was obtained in all 5 cases and no case showed skin photosensitivity when exposed to sunlight under careful surveillance at one week after PDT.


2021 ◽  
Vol 2 (12(81)) ◽  
pp. 39-43
Author(s):  
M. Ibragimov ◽  
Y. Heydarova ◽  
A. Alizade ◽  
L. Ibragimova

This scientific article discusses the oral manifestations of diseases of the gastrointestinal tract. This problem is relevant both for dentists and family doctors. In medicine, for a long period of time, the relationship between diseases affecting the gastrointestinal tract and their symptoms manifested in the oral cavity has been considered. Many scientists and physicians have dealt with this problem, their several opinions are presented in this article. There is a hypothesis among researchers that the oral cavity is a mirror in which all human diseases can be visible. In the oral cavity, most of the alterations occurring in the organism are manifested, due to which, with an attentive attitude to oral manifestations, the disease can be detected already at the initial stage.


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