Chaya Sindaghatta Krishnarao
◽
Mahendra Maheshwarappa
◽
Thippeswamy Thippeswamy
◽
Jayaraj Biligere Siddaiah
◽
Komarla Sundararaja Lokesh
◽
...
Background:
Chronic Obstructive Pulmonary Disease is an important cause of morbidity
and mortality globally. The onset of pulmonary hypertension and corpulmonale is associated with
decreased survival in patients with COPD.
Objective:
To assess risk factors associated with the development of pulmonary hypertension and
corpulmonale and to identify high-risk phenotypes who may need early evaluation and intervention.
Methods:
Consecutive adult patients with COPD were evaluated for factors influencing the
development of pulmonary hypertension and corpulmonale which included symptomatology,
hospitalization in the previous year, MMRC dyspnea grade, SGRQ score, 6 minute walk test, ABG,
CRP, spirometry and echocardiography.
Results:
We found Pulmonary Hypertension in 36(30%) patients and 27(22.5%) had corpulmonale.
On multivariate analysis, we found PaO2 ≤75 mm Hg and six minute walk test <80% predicted to be
significantly associated with the development of Pulmonary hypertension and we found
hospitalization in the previous year to be significantly and independently associated with the
development of corpulmonale.
Conclusion:
We observed hospitalization in the previous year was an independent risk factor for the
development of corpulmonale and six-minute walk test <80% predicted, PaO2 <75 mm Hg were
independent risk factors for the development of pulmonary hypertension.
Delta Performance of Oxygen Saturation in the Six Minute Walk Test for Pulmonary Hypertension by Echocardiography
