Clinical characteristics, prognosis, and seropositivity to the anti-aquaporin-4 antibody in Korean patients with longitudinally extensive transverse myelitis

2010 ◽  
Vol 257 (6) ◽  
pp. 920-925 ◽  
Author(s):  
Su Hyun Kim ◽  
Sung Min Kim ◽  
Angela Vincent ◽  
Suk Won Ahn ◽  
Yoon Ho Hong ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Korean Patients ◽  
Aquaporin 4 Antibody ◽  
Extensive Transverse Myelitis

Systemic sclerosis in aquaporin-4 antibody-positive longitudinally extensive transverse myelitis

2011 ◽  
Vol 303 (1-2) ◽  
pp. 139-141 ◽  
Author(s):  
Diego Franciotta ◽  
Elisabetta Zardini ◽  
Roberto Caporali ◽  
Laura Piccolo ◽  
Elisa Alberici ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Aquaporin 4 Antibody ◽  
Extensive Transverse Myelitis

scholarly journals The expanded spectrum of neuromyelitis optica: evidences for a new definition

2012 ◽  
Vol 70 (10) ◽  
pp. 807-813 ◽  
Author(s):  
Marco A Lana-Peixoto ◽  
Dagoberto Callegaro
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Brain Mri ◽  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Index Event ◽  
Aquaporin 4 Antibody ◽  
Extensive Transverse Myelitis

Neuromyelitis optica (NMO) has been traditionally described as the association of recurrent or bilateral optic neuritis and longitudinally extensive transverse myelitis (LETM). Identification of aquaporin-4 antibody (AQP4-IgG) has deeply changed the concept of NMO. A spectrum of NMO disorders (NMOSD) has been formulated comprising conditions which include both AQP4-IgG seropositivity and one of the index events of the disease (recurrent or bilateral optic neuritis and LETM). Most NMO patients harbor asymptomatic brain MRI lesions, some of them considered as typical of NMO. Some patients with aquaporin-4 autoimmunity present brainstem, hypothalamic or encephalopathy symptoms either preceding an index event or occurring isolatedly with no evidence of optic nerve or spinal involvement. On the opposite way, other patients have optic neuritis or LETM in association with typical lesions of NMO on brain MRI and yet are AQP4-IgG seronegative. An expanded spectrum of NMO disorders is proposed to include these cases.

Antibodies to myelin oligodendrocyte glycoprotein in aquaporin 4 antibody seronegative longitudinally extensive transverse myelitis: Clinical and prognostic implications

2015 ◽  
Vol 22 (3) ◽  
pp. 312-319 ◽  
Author(s):  
Álvaro Cobo-Calvo ◽  
María Sepúlveda ◽  
Raphael Bernard-Valnet ◽  
Anne Ruiz ◽  
David Brassat ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Transverse Myelitis ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Aquaporin 4 ◽  
First Episode ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Increase Risk ◽  
Cerebrospinal Fluid Pleocytosis ◽  
Aquaporin 4 Antibody ◽  
Extensive Transverse Myelitis

Objective: We aimed to investigate the frequency and clinical significance of antibodies to myelin oligodendrocyte glycoprotein (MOG-abs) in patients who presented with a first episode of seronegative aquaporin 4 antibody (AQP4-ab) longitudinally extensive transverse myelitis (LETM). Methods: Epidemiological, clinical, and paraclinical data of 56 patients from three European centres were analysed. Patients were retrospectively tested for MOG-abs and AQP4-abs, by cell-based assays. Findings: Thirteen (23.2%) patients were MOG-ab positive. Among the 56 patients, six (10.7%) converted to neuromyelitis optica (NMO), one (1.8%) to multiple sclerosis (MS), nine (16.1%) had recurrent LETM, and 40 (71.4%) remained as monophasic LETM. Compared with seronegative patients, those with MOG-abs were younger (median: 32.5 vs 44 years; p=0.007), had cerebrospinal fluid pleocytosis more frequently (94% vs 45%, p=0.003) and had better outcome (median Expanded Disability Status Scale (EDSS) 2.0 vs 3.0, p=0.027). MOG-ab positive patients also showed an increase risk of optic neuritis relapse and NMO conversion ( p=0.010). Conclusion: Patients with MOG-abs in AQP4-ab seronegative LETM have clinical distinctive features, higher risk of optic neuritis relapses, and better outcome than patients seronegative.

Aquaporin-4 antibody positive longitudinally extensive transverse myelitis following varicella zoster infection

2009 ◽  
Vol 276 (1-2) ◽  
pp. 184-186 ◽  
Author(s):  
Kristin Heerlein ◽  
Sven Jarius ◽  
Christian Jacobi ◽  
Stefan Rohde ◽  
Brigitte Storch-Hagenlocher ◽  
...  
Keyword(s):  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Varicella Zoster ◽  
Aquaporin 4 Antibody ◽  
Varicella Zoster Infection ◽  
Extensive Transverse Myelitis

Longitudinally extensive transverse myelitis immune-mediated in aquaporin-4 antibody negative patients: Disease heterogeneity

2017 ◽  
Vol 373 ◽  
pp. 134-137 ◽  
Author(s):  
Edgar Carnero Contentti ◽  
Javier Pablo Hryb ◽  
Sergio Morales ◽  
Alejandra Gomez ◽  
Edson Chiganer ◽  
...  
Keyword(s):  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Disease Heterogeneity ◽  
Immune Mediated ◽  
Aquaporin 4 Antibody ◽  
Extensive Transverse Myelitis

scholarly journals Long extensive transverse myelitis associated with aquaporin-4 antibody and breast cancer: Favorable response to cancer treatment

2012 ◽  
Vol 35 (4) ◽  
pp. 267-269 ◽  
Author(s):  
Haydar Armağan ◽  
Erdem Tüzün ◽  
Sema İçöz ◽  
Ömer Birişik ◽  
Canan Ulusoy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Aquaporin 4 Antibody ◽  
Extensive Transverse Myelitis
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