scholarly journals Comparative quantification of focal and diffuse visual field loss by the SPARK Precision threshold algorithm and SITA

2021 ◽  
Author(s):  
S. K. Foo ◽  
R. P. Cubbidge ◽  
R. Heitmar
Keyword(s):  
Visual Field ◽  
Dynamic Range ◽  
Visual Field Loss ◽  
Linear Interpolation ◽  
Angle Closure ◽  
Testing Time ◽  
Global Indices ◽  
Primary Angle Closure Glaucoma ◽  
Threshold Algorithm ◽  
Long Term Follow Up

Abstract Purpose The aims of this paper were to examine focal and diffuse visual field loss in terms of threshold agreement between the widely used SITA Standard Humphrey Field Analyser (HFA) threshold algorithm with the SPARK Precision algorithm (Oculus Twinfield 2). Methods A total of 39 treated glaucoma patients (34 primary open angle and 5 primary angle closure glaucoma) and 31 cataract patients without glaucoma were tested in succession with the Oculus Twinfield 2 (Oculus Optikgeräte GmbH, Wetzlar, Germany) using the SPARK Precision algorithm and with the HFA 3 (Carl Zeiss Meditec, Dublin, CA) using the 30–2 SITA Standard algorithm. Results SPARK Precision required around half the testing time of SITA Standard. There was a good correlation between the MS of the two threshold algorithms but MD and PSD were significantly less severe with SPARK Precision in both glaucoma (focal field loss) and cataract (diffuse field loss) groups (p < 0.001). There was poor agreement for all global indices (MS, MD and PSD) between the two algorithms and there was a significant proportional bias of MD in the glaucoma group and PSD in both glaucoma and cataract groups. The pointwise sensitivity analysis yielded higher threshold estimates in SPARK Precision than in SITA Standard in the nasal field. Classification of glaucoma severity using AGIS was significantly lower with SPARK Precision compared to SITA Standard (p < 0.001). Conclusion SITA renders deeper defects than SPARK. Compared to the SITA Standard threshold algorithm, SPARK Precision cannot quantify early glaucomatous field loss. This may be due to the mathematical linear interpolation of threshold sensitivity or deeper scotomas due to the plateau effect caused by the reduced dynamic range of the Twinfield 2 perimeter. Although not of clinical significance in early glaucoma, the plateau effect may hinder the long-term follow-up of patients during disease progression.

Pattern of Visual Field Loss in Primary Angle-Closure Glaucoma Across Different Severity Levels

Ophthalmology ◽  
2016 ◽  
Vol 123 (9) ◽  
pp. 1957-1964 ◽  
Author(s):  
Eray Atalay ◽  
Monisha E. Nongpiur ◽  
Sae Cheong Yap ◽  
Tina T. Wong ◽  
David Goh ◽  
...  
Keyword(s):  
Visual Field ◽  
Visual Field Loss ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Severity Levels

scholarly journals Correlation between Intraocular Pressure and Visual Field Loss in Primary Open Angle and Primary Angle Closure Glaucoma: A Cross-Sectional Study

2021 ◽  
Author(s):  
VR Raji ◽  
Susan Philip ◽  
Ambily S
Keyword(s):  
Intraocular Pressure ◽  
Visual Field ◽  
Pearson Correlation ◽  
Visual Field Loss ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Open Angle ◽  
Cross Sectional ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Introduction: Glaucoma is characterised by structural damage to optic nerve head with corresponding visual field defects and often associated with increased Intraocular Pressure (IOP). It may be broadly classified as Primary Angle Closure Glaucoma (PACG) and Primary Open Angle Glaucoma (POAG). It is one of the leading causes of global blindness, and a major proportion occurs in Indian population. Aim: To study the correlation between pretreatment IOP and extent of visual field loss in PACG and POAG. Materials and Methods: A cross-sectional observational study was carried out in Regional Institute of Ophthalmology, Trivandrum, Kerala, India from April 2016 to May 2017. Newly diagnosed cases of PACG (25 patients-13 males, 12 females, mean age 58.72±10.07 years) and POAG (85 patients- 45 males, 40 females, mean age 60.28±10.42 years) underwent a detailed glaucoma evaluation which included IOP measurement with Goldmann applanation tonometer and visual field testing using Humphrey Field Analysis (HFA) 24-2 pattern. Mean Deviation (MD), Pattern Standard Deviation (PSD) and Advanced Glaucoma Intervention Score (AGIS) score was calculated from reliable visual field test result. All data were coded and entered in to statistical software, Statistical Package for Social Sciences (SPSS) version 16.0 for analysis. The correlation between pretreatment IOP and visual field loss in patients with PACG and POAG was determined by Pearson Correlation of Coefficient. Results: Amongst the total 110 patients of this study, 25 patients were of PACG while POAG were in 85 patients. A significant correlation between pre treatment IOP and the extent of visual field loss in PACG was noted. There was no significant correlation in POAG. Linear regression analysis demonstrated a significant positive correlation between IOP and AGIS score in PACG (Pearson correlation coefficient(r)=0.805, p<0.001), not in POAG (r=0.026, p=0.816). Correlation between IOP and MD is statistically significant in PACG (r=0.812, p<0.001) but not in POAG (r=0.058, p=0.597). The correlation between IOP and PSD is not statistically significant in both groups (p-value >0.450). Conclusion: A significant correlation between IOP and visual field loss in PACG indicates that extent of visual field damage can be controlled by controlling IOP alone in PACG. The correlation between the pretreatment IOP and visual field loss in POAG is not statistically significant which agrees with the current proposed pathophysiology of optic neuropathy in which multiple factors influence in addition to IOP.

Visual field loss from primary angle-closure glaucoma

Ophthalmology ◽  
2004 ◽  
Vol 111 (9) ◽  
pp. 1636-1640 ◽  
Author(s):  
Leonard P.K. Ang ◽  
Tin Aung ◽  
Wei-Han Chua ◽  
Leonard W. Yip ◽  
Paul T.K. Chew
Keyword(s):  
Visual Field ◽  
Visual Field Loss ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Serum complement component 3, complement component 4 and complement component 1q levels predict progressive visual field loss in older women with primary angle closure glaucoma

2022 ◽  
pp. bjophthalmol-2021-320541
Author(s):  
Shengjie Li ◽  
Yichao Qiu ◽  
Jian Yu ◽  
Mingxi Shao ◽  
Yingzhu Li ◽  
...  
Keyword(s):  
Visual Field ◽  
Older Women ◽  
Statistical Significance ◽  
Serum Levels ◽  
Complement Component ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Generalised Additive Model ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

AimTo evaluate the association between serum levels of complement component (C) 3, C4 and C1q and visual field (VF) loss in patients with primary angle closure glaucoma (PACG).MethodsIn this prospective cohort study, a total of 308 patients with PACG were included. The patients were followed up every 6 months (at least 2 years), with clinical examination and VF testing. Based on their sex and age, the subjects were stratified into male and female subgroups, and by age at <60 and ≥60 years per subgroup.ResultsOne hundred twenty-three (39.94%) patients showed glaucoma VF progression. The serum levels of C3, C4 and C1q were significantly lower (p<0.05) in the progression group compared with the non-progression group in the ≥60 years female subgroup. In female patients with age ≥60 years, (1) lower levels of baseline C3 (HR=0.98, p<0.001), C4 (HR=0.96, p=0.01) and C1q levels (HR=0.99, p=0.003) were associated with a greater risk of VF progression; (2) patients with lower C3 levels had significantly (p<0.05) higher rates of VF loss progression, similar to those with lower C4 and lower C1q levels; and (3) the generalised additive model revealed a negative correlation between baseline C3 (p<0.001), C4 (p<0.001) and C1q (p<0.001) levels with the risk of VF progression. No statistical significance was observed in the male (<60 and ≥60 years) and female (<60 years) subgroups.ConclusionDecreased C3, C4 and C1q levels at baseline were significantly associated with a greater risk of VF loss progression only in older women with PACG.

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