Serum complement component 3, complement component 4 and complement component 1q levels predict progressive visual field loss in older women with primary angle closure glaucoma

2022 ◽  
pp. bjophthalmol-2021-320541
Author(s):  
Shengjie Li ◽  
Yichao Qiu ◽  
Jian Yu ◽  
Mingxi Shao ◽  
Yingzhu Li ◽  
...  
Keyword(s):  
Visual Field ◽  
Older Women ◽  
Statistical Significance ◽  
Serum Levels ◽  
Complement Component ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Generalised Additive Model ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

AimTo evaluate the association between serum levels of complement component (C) 3, C4 and C1q and visual field (VF) loss in patients with primary angle closure glaucoma (PACG).MethodsIn this prospective cohort study, a total of 308 patients with PACG were included. The patients were followed up every 6 months (at least 2 years), with clinical examination and VF testing. Based on their sex and age, the subjects were stratified into male and female subgroups, and by age at <60 and ≥60 years per subgroup.ResultsOne hundred twenty-three (39.94%) patients showed glaucoma VF progression. The serum levels of C3, C4 and C1q were significantly lower (p<0.05) in the progression group compared with the non-progression group in the ≥60 years female subgroup. In female patients with age ≥60 years, (1) lower levels of baseline C3 (HR=0.98, p<0.001), C4 (HR=0.96, p=0.01) and C1q levels (HR=0.99, p=0.003) were associated with a greater risk of VF progression; (2) patients with lower C3 levels had significantly (p<0.05) higher rates of VF loss progression, similar to those with lower C4 and lower C1q levels; and (3) the generalised additive model revealed a negative correlation between baseline C3 (p<0.001), C4 (p<0.001) and C1q (p<0.001) levels with the risk of VF progression. No statistical significance was observed in the male (<60 and ≥60 years) and female (<60 years) subgroups.ConclusionDecreased C3, C4 and C1q levels at baseline were significantly associated with a greater risk of VF loss progression only in older women with PACG.

scholarly journals Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Shengjie Li ◽  
Mingxi Shao ◽  
Yingzhu Li ◽  
Xiaojuan Li ◽  
Yani Wan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Regression Analysis ◽  
Visual Field ◽  
Serum Levels ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Cox Regression Analysis ◽  
Visual Field Progression ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Purpose. To investigate the serum changes of oxidative stress markers and the relationship between these factors and visual field (VF) progression in patients with primary angle closure glaucoma (PACG). Methods. A case-control and a prospective cohort study. A total of 94 patients with PACG and 89 normal controls were enrolled. Furthermore, 94 PACG subjects were followed up for at least two years (once every six months). All participants were evaluated for serum levels of superoxide dismutase (SOD), total antioxidant status (TAS), hydrogen peroxide (H2O2), malondialdehyde (MDA), glutathione peroxidase, glutathione reductase, and detailed eye and systematic examination. Binary logistic regression analysis and Cox regression analysis were performed. Results. The serum levels of SOD and TAS in the PACG group were significantly lower than those in the control group (p<0.001). Meanwhile, PACG subjects had significantly higher levels of MDA and H2O2 than the normal control subjects (p<0.001). Serum levels of TAS (OR=0.773, 95%CI=0.349−0.714, p<0.001), SOD (OR=0.975, 95%CI=0.955−0.995, p<0.001), MDA (OR=1.155, 95%CI=1.080−1.235, p<0.001), and H2O2 (OR=1.216, 95%CI=1.142−1.295, p<0.001) were independent risk/protective factors for PACG. TAS levels (HR=0.041, 95%CI=0.008–0.218, p<0.001), SOD levels (HR=0.983, 95%CI=0.971–0.994, p=0.003), and MDA levels (HR=1.010, 95%CI=1.001–1.018, p=0.015) at baseline were associated with visual field progression. Kaplan–Meier curves reveal that patients with TAS<0.95/SOD<143/MDA>12 had a significantly higher percentage of PACG progression (p<0.05). Conclusions. Decreased levels of TAS and SOD as well as increased levels of MDA at baseline were associated with VF progression in patients with PACG. These findings suggest that oxidative stress was involved in the onset and development of PACG.

scholarly journals Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ruyue Shen ◽  
Yu Meng Wang ◽  
Carol Y. Cheung ◽  
Poemen P. Chan ◽  
Clement C. Tham
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Field ◽  
Disease Severity ◽  
Optical Coherence Tomography Angiography ◽  
Normal Tension Glaucoma ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Rnfl Thickness

AbstractTo investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A). One or both eyes of each subject were imaged for a 3 × 3 mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined. Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of 49 control subjects were cross-sectionally analyzed. NTG eyes had significantly lower global cpVD (52.369 ± 0.781%) compared with PACG eyes (55.389 ± 0.721%, P = 0.004) that had comparable disease severity and average RNFL thickness. Multivariable analysis revealed that, for PACG and NTG eyes, decreased cpVD ([PACG] β = −4.242; CI: −8.120, −0.363 vs [NTG] β = −5.531; CI: −9.472, −1.590) and cpFD ([PACG] β = −8.894;CI: −11.925, −5.864 vs [NTG] β = −12.064; CI: −17.095, −6.932) were associated with decreased RNFL thickness (all P ≤ 0.032); with a stronger association between decrease cpFD and decreased RNFL thickness in NTG eyes (P = 0.028). Decreased cpVD was associated with decrease mean deviation (MD) in NTG eyes (β = −0.707; CI: −1.090, −0.324; P ≤ 0.001) and not associated with the visual field parameters in PACG eyes. Early NTG had lower global cpVD compared with early PACG, despite similar disease severity and average RNFL thickness.

scholarly journals Levels of Plasma 8-Hydroxy-2'-Deoxyguanosine—A Marker of Oxidative DNA Damage—Are Not Associated with Primary Angle-closure Glaucoma

2021 ◽  
pp. 132-138
Author(s):  
Altaf A. Kondkar
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Statistical Significance ◽  
Characteristic Curve ◽  
Angle Closure Glaucoma ◽  
University Hospital ◽  
Angle Closure ◽  
Clinical Markers ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Aim: The study aimed to estimate plasma 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels, a marker of oxidative deoxyribonucleic acid (DNA) damage, and evaluate their potential association with primary angle-closure glaucoma (PACG) and related clinical markers. Study Design: This is retrospective case-control study. Place and Duration: The study was performed on samples recruited from King Abdulaziz University Hospital, Riyadh, Saudi Arabia between August 2018 through September 2019 in the participants of Saudi origin. Methodology: Plasma 8-OHdG levels were measured in duplicates using automated ELISA analyzer in 43 PACG patients and 45 non-glaucomatous controls. Results: The mean levels of 8-OHdG were 13.59 ng/mL [±4.50] in PACG patients compared to 16.95 ng/mL [±10.66] in controls. The differences did not achieve statistical significance (P = 0.06). Similarly, no significant differences (P = 0.42) were observed in the median levels of 8-OHdG between PACG and controls. Furthermore, except for sex, where males exhibited a significant negative correlation (R = -0.35, P = 0.02), there was no significant correlation between 8-OHdG levels and age (P = 0.85), intraocular pressure (P = 0.58), cup/disc ratio (P = 0.39) and number of antiglaucoma medications (P = 0.41) in the PACG group. Regression analysis showed no significant influence of age, sex, and 8-OHdG levels on PACG outcome. Besides, the area under the receiver operating characteristic curve was 0.55 and non-significant (P = 0.42). Conclusion: There is no association between plasma levels of 8-OHdG and PACG or its specific clinical markers. Further studies in a much larger cohort are needed to validate these findings.

scholarly journals Difference of Heat Shock Protein 70 Serum Level Between Primary Angle Closure Glaucoma and Open Angle Glaucoma Patients: Indonesia Single Center Experience

2021 ◽  
Vol 57 (3) ◽  
pp. 205
Author(s):  
Mohamad Nurdin Zuhri ◽  
Nurwasis Nurwasis ◽  
Endang Retnowati ◽  
Windhu Purnomo
Keyword(s):  
Serum Level ◽  
Open Angle Glaucoma ◽  
Sandwich Elisa ◽  
Serum Levels ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Open Angle ◽  
Hsp 70 ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

This study aimed to analyze the differences in Hsp 70 serum levels in patients with primary angle-closure compared to patients with open-angle glaucoma at Dr. Soetomo General Academic Hospital, Surabaya, East Java. This cross-sectional study was conducted on 41 subjects divided into 2 groups consisting of 21 patients with primary angle-closure glaucoma and 20 patients with open-angle glaucoma. Anterior segment examination was assessed by slit-lamp biomicroscope examination. Intraocular pressure on both eyes was measured by Perkin’s tonometry. Posterior segment examination was performed with 78 D lens and anterior chamber angle was assessed by goniolens. The serum level of Hsp 70 was assessed using a human Hsp 70 sandwich ELISA kit. The data were statistically analyzed with the Mann-Whitney test. The mean serum levels of Hsp 70 in the primary angle-closure group was 5.55  4.75 ng/ml, while the open-angle group was 3.62  2.39 ng/ml (p = 0.134). There was no difference in Hsp 70 serum levels between the two groups, although the trend obtained serum levels of Hsp 70 patients with primary angle-closure was higher compared to patients with open-angle.

scholarly journals Profile of the glaucomas and intervention in a large eye care centre in South-East Nepal

1970 ◽  
Vol 2 (1) ◽  
pp. 3-9 ◽  
Author(s):  
S Sarkar ◽  
C Mardin ◽  
A Henning
Keyword(s):  
Visual Field ◽  
Visually Impaired ◽  
Open Angle Glaucoma ◽  
Outcome Measurement ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Visual Field Defects ◽  
Primary Angle Closure ◽  
North East ◽  
Primary Angle Closure Glaucoma

Introduction: Glaucoma is the second leading cause of blindness worldwide. Objective:To estimate the prevalence and risk factors of glaucoma and modes of therapeutical intervention in a rural population of a developing country. Patients and methods: A single centre-based cross-sectional study was carried out over a seven-month period in Sagarmatha Choudhary Eye Hospital (SCEH), Lahan/NEPAL, including the patients with glaucoma. Outcome measurement: The patients' demography, type of the glaucomas, visual acuity, vertical cup-disc ratio, intra-ocular pressure and visual field findings were the parameters studied. Results: A total of 3986 eyes with suspected glaucoma were identified. 53.7 % of the patients were between 41- 60 years of age. 53.9 % were male. 26.5 % were blind or severely visually impaired. 37.2 % had IOP more than 35 mmHg. 46.4 % had vertical cup-disc ratio (VCDR) higher than 0.8. Severe visual field defects were found in 28.4 % eyes. 35.3% eyes had primary angle-closure glaucoma, 22.6 % eyes primary open-angle glaucoma, and 14.6 % eyes normaltension glaucoma. 10.2 % eyes suffered from lens induced glaucoma. Only in 9 eyes was pseudoexfoliation syndrome with glaucoma diagnosed. 25.7 % eyes were advised for trabeculectomy. 11.5 % eyes underwent extra-capsular cataract surgery. IOP lowering medication was prescribed in 5.9 % patients. Conclusions: The most common glaucoma seen in the out-patient department of a large eyecare centre in South-East Nepal is primary angle-closure glaucoma. 25 % of the glaucoma patients are visually impaired or blind at the time of presentation. In more than one-fourth of the patients, trabeculectomy is the therapy of choice. Keywords: glaucoma; South-East Nepal; North-East India; Bihar; blindness. DOI: 10.3126/nepjoph.v2i1.3697 Nep J Oph 2010;2(1):3-9

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