Autophagic and proteolytic processes in the Harderian gland are modulated during the estrous cycle

2013 ◽  
Vol 141 (5) ◽  
pp. 519-529 ◽  
Author(s):  
M. García-Macia ◽  
A. Rubio-Gonzalez ◽  
B. de Luxán-Delgado ◽  
Y. Potes ◽  
S. Rodríguez-González ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Harderian Gland

Immunoreactive somatostatin diurnal rhythms in rat pineal, retina and Harderian gland: Effects of sex, season, continuous darkness and estrous cycle

1990 ◽  
Vol 81 (1) ◽  
pp. 63-72 ◽  
Author(s):  
M. A. Peinado ◽  
N. Fajardo ◽  
G. Hern�ndez ◽  
M. Puig-Domingo ◽  
M. Viader ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Harderian Gland ◽  
Diurnal Rhythms ◽  
Continuous Darkness

Mast cells in the Harderian gland of female syrian hamsters during the estrous cycle and pregnancy: effects of the light/dark cycle

1993 ◽  
Vol 25 (1) ◽  
pp. 51-61 ◽  
Author(s):  
Armando Menendez-Pelaez ◽  
Rosa M. Sainz ◽  
Juan C. Mayo ◽  
Maria J. Rodriguez-Colunga ◽  
Julio Vazquez-Rojo ◽  
...  
Keyword(s):  
Mast Cells ◽  
Estrous Cycle ◽  
Harderian Gland ◽  
Dark Cycle ◽  
Syrian Hamsters

scholarly journals Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the estrous cycle: a potential retrieval effect of melatonin

2019 ◽  
Author(s):  
Marina García-Macia ◽  
Adrián Santos-Ledo ◽  
Beatriz Caballero ◽  
Adrián Rubio-González ◽  
Beatriz de Luxán-Delgado ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Harderian Gland ◽  
Mitochondrial Homeostasis ◽  
Perfect Model ◽  
Nrf2 Activation ◽  
Sexual Bias ◽  
The Impact ◽  
Nrf2 Expression ◽  
Retrieval Phase

ABSTRACTSexual dimorphism has been reported in many processes. However, sexual bias in favor of the use of males is very present in science. One of the main reasons is that the impact of hormones in diverse pathways and processes such as autophagy have not been properly addressed in vivo. The Harderian gland is a perfect model to study autophagic modulation as it exhibits important changes during the estrous cycle. The aim of this study is to identify the main processes behind Harderian gland differences under estrous cycle and their modulator. In the present study we show that redox-sensitive transcription factors have an essential role: NF-κB may activate SQSTM1/p62 in estrus, promoting selective types of autophagy: mitophagy and lipophagy. Nrf2 activation in diestrus, leads the retrieval phase and restoration of mitochondrial homeostasis. Melatonin’s receptors show higher expression in diestrus, leading to decreases in pro-inflammatory mediators and enhanced Nrf2 expression. Consequently, autophagy is blocked, and porphyrin release is reduced. All these results point to melatonin as one of the main modulators of the changes in autophagy during the estrous cycle.

Further Studies on the Ultrastructure of Harderian Gland in Adult Rats

1974 ◽  
Vol 32 ◽  
pp. 288-289
Author(s):  
Alfredo Feria-Velasco ◽  
Guadalupe Tapia-Arizmendi
Keyword(s):  
Fine Structure ◽  
Domestic Fowl ◽  
Animal Species ◽  
Acinar Cells ◽  
Harderian Gland ◽  
Myoepithelial Cells ◽  
The Other ◽  
Albino Rats ◽  
Adult Rats ◽  
Cell Components

The fine structure of the Harderian gland has been described in some animal species (hamster, rabbit, mouse, domestic fowl and albino rats). There are only two reports in the literature dealing on the ultrastructure of rat Harderian gland in adult animals. In one of them the author describes the myoepithelial cells in methacrylate-embbeded tissue, and the other deals with the maturation of the acinar cells and the formation of the secretory droplets. The aim of the present work is to analize the relationships among the acinar cell components and to describe the two types of cells located at the perifery of the acini.

Rat Ovarian Renin: Characterization and Changes during the Estrous Cycle*

Endocrinology ◽  
1988 ◽  
Vol 123 (5) ◽  
pp. 2331-2340 ◽  
Author(s):  
RANDY B. HOWARD ◽  
ANTHONY G. PUCELL ◽  
F. MERLIN BUMPUS ◽  
AHSAN HUSAIN
Keyword(s):  
Estrous Cycle

Effects of sex and estrous cycle on the brain and plasma arginine metabolic profile in rats

Amino Acids ◽  
2021 ◽  
Author(s):  
Jiaxian Zhang ◽  
Yu Jing ◽  
Hu Zhang ◽  
Ping Liu
Keyword(s):  
Estrous Cycle ◽  
Metabolic Profile ◽  
Plasma Arginine ◽  
The Brain

scholarly journals 140 Effect of hCG on the last day of the 5-d CIDR-Synch and/or on day 5 of the estrous cycle on luteal dynamics in recipient Holstein heifers

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 112-113
Author(s):  
Marcelo Siqueira El Azzi ◽  
Everardo Anta Galvan ◽  
Teresita Valdes Arciniega ◽  
Iago Leão ◽  
Rodrigo Sala ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Ovulation Rate

Abstract The objective was to determine the effect of hCG (3,300 IU) administered on days 0 and/or 5 of the estrous cycle on total luteal area (TLA) and circulating concentrations of progesterone (P4) in recipient heifers. All heifers (n = 232; BCS = 3.3 ± 0.2) were synchronized with a 5d CIDR-Synch protocol (d-8: used CIDR inserted; d-3: CIDR removed and PGF2α treatment; d0: 100µg GnRH or hCG). Heifers were randomly assigned to four treatments: control, hCGd0, hCGd5, and hCGd0&5. Controls were treated with GnRH on d0, while hCGd0 received hCG on d0. hCGd5 heifers were treated with GnRH on d0 and hCG on d5, while hCGd0&5 received hCG on d0 and 5. Ovaries were scanned by ultrasound on d0, 5, and 12. Blood was collected on d0, 5, 7, and 12. Synchronization rate (94%) did not differ (P = 0.94) by treatment. Treatment differences were only tested in synchronized heifers (n = 218). Proportion of heifers with 1 or 2+ CL on d5 did not differ (P = 0.10) for hCG d0 treatments (hCGd0 + hCGd0&5) vs. GnRH d0 treatments (controls + hCGd5). However, heifers treated with hCG on d0 had greater (P < 0.01) TLA and P4 on d5 vs. treatments with GnRH on d0 (311 ± 13 vs. 257 ± 9 mm2; and 2.39 ± 0.15 vs. 1.90 ± 0.09 ng/mL). Ovulation rate for d5 hCG did not differ (P = 0.63) for hCGd5 vs. hCGd0&5 (93 vs. 84%). Controls had the lowest serum P4 on d7 and 12. In contrast, hCGd0&5 had the highest serum P4 on d7 (Table 1). Serum P4 on d7 did not differ for hCGd0 vs. hCGd5. On d12, serum P4 and TLA were not different for hCGd5 vs. hCGd0&5. These data indicate that hCG can be used on d0 to induce an increase in serum P4 on d5 compared to GnRH. However, only heifers treated with hCG on d5 achieved mean serum P4 > 8ng/mL.

scholarly journals Properties of dihydroxyacetone phosphate acyltransferase in the harderian gland.

1977 ◽  
Vol 252 (18) ◽  
pp. 6363-6366 ◽  
Author(s):  
C O Rock ◽  
V Fitzgerald ◽  
F Snyder
Keyword(s):  
Harderian Gland ◽  
Dihydroxyacetone Phosphate
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