The heat shock protein response following eccentric exercise in human skeletal muscle is unaffected by local NSAID infusion

2013 ◽  
Vol 113 (7) ◽  
pp. 1883-1893 ◽  
Author(s):  
U. R. Mikkelsen ◽  
G. Paulsen ◽  
P. Schjerling ◽  
I. C. Helmark ◽  
H. Langberg ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Eccentric Exercise ◽  
Human Skeletal Muscle ◽  
Protein Response

scholarly journals Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization

2019 ◽  
Vol 127 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Paul S. Hafen ◽  
Kaitlin Abbott ◽  
Jennifer Bowden ◽  
Ryan Lopiano ◽  
Chad R. Hancock ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Skeletal Muscle ◽  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Mitochondrial Function ◽  
Human Skeletal Muscle ◽  
Respiratory Capacity ◽  
Sham Treatment ◽  
Limb Immobilization

Skeletal muscle immobilization leads to atrophy, decreased metabolic health, and substantial losses in function. Animal models suggest that heat stress can provide protection against atrophy in skeletal muscle. This study investigated the effects of daily heat therapy on human skeletal muscle subjected to 10 days of immobilization. Muscle biopsies were collected, and MRIs were analyzed from the vastus lateralis of 23 healthy volunteers (11 women, 12 men) before and after either 10 days of immobilization with a daily sham treatment (Imm) or with a targeted, daily 2-h heat treatment using pulsed shortwave diathermy (Imm + H). Diathermy increased intramuscular temperature 4.2 ± 0.29°C ( P < 0.0001), with no change during sham treatment. As a result, heat shock protein (HSP)70 and HSP90 increased ( P < 0.05) following Imm + H (25 ± 6.6 and 20 ± 7.4%, respectively) but were unaltered with Imm only. Heat treatment prevented the immobilization-induced loss of coupled (−27 ± 5.2% vs. −8 ± 6.0%, P = 0.0041) and uncoupled (−25 ± 7.0% vs. −10 ± 3.9%, P = 0.0302) myofiber respiratory capacity. Likewise, heat treatment prevented the immobilization-induced loss of proteins associated with all five mitochondrial respiratory complexes ( P < 0.05). Furthermore, decreases in muscle cross-sectional area following Imm were greater than Imm + H at both the level of the whole muscle (−7.6 ± 0.96% vs. −4.5 ± 1.09%, P = 0.0374) and myofiber (−10.8 ± 1.52% vs. −5.8 ± 1.49%, P = 0.0322). Our findings demonstrate that daily heat treatments, applied during 10 days of immobilization, prevent the loss of mitochondrial function and attenuate atrophy in human skeletal muscle. NEW & NOTEWORTHY Limb immobilization results in substantial decreases in skeletal muscle size, function, and metabolic capacity. To date, there are few, if any, interventions to prevent the deleterious effects of limb immobilization on skeletal muscle health. Heat stress has been shown to elicit a stress response, resulting in increased heat shock protein expression and improved mitochondrial function. We show that during 10 days of lower-limb immobilization in humans, daily exposure to heat stress maintains mitochondrial respiratory capacity and attenuates atrophy in skeletal muscle. Our findings suggest that heat stress may serve as an effective therapeutic strategy to attenuate the decreases of muscle mass and metabolic function that accompany periods of disuse.

Exercise training-induced gender-specific heat shock protein adaptations in human skeletal muscle

2009 ◽  
Vol 39 (2) ◽  
pp. 230-233 ◽  
Author(s):  
James P. Morton ◽  
Kathryn Holloway ◽  
Paul Woods ◽  
Nigel T. Cable ◽  
Jatin Burniston ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Shock ◽  
Exercise Training ◽  
Heat Shock Protein ◽  
Specific Heat ◽  
Human Skeletal Muscle ◽  
Gender Specific

Microwave Treatment Induces Heat Shock Protein 72 in Human Skeletal Muscle

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S548 ◽  
Author(s):  
Yuji Ogura ◽  
Hisashi Naito ◽  
Norio Saga ◽  
Shizuo Katamoto ◽  
Toshihiro Tsurukawa ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Human Skeletal Muscle ◽  
Microwave Treatment ◽  
Heat Shock Protein 72

The expression of heat shock protein in human skeletal muscle: effects of muscle fibre phenotype and training background

2013 ◽  
Vol 209 (1) ◽  
pp. 26-33 ◽  
Author(s):  
M. Folkesson ◽  
A. L. Mackey ◽  
H. Langberg ◽  
E. Oskarsson ◽  
K. Piehl-Aulin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Muscle Fibre ◽  
Human Skeletal Muscle ◽  
Training Background ◽  
And Training

scholarly journals Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle.

1992 ◽  
Vol 267 (11) ◽  
pp. 7718-7725 ◽  
Author(s):  
K Kato ◽  
H Shinohara ◽  
S Goto ◽  
Y Inaguma ◽  
R Morishita ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Human Skeletal Muscle ◽  
Small Heat Shock Protein

scholarly journals Microwave hyperthermia treatment increases heat shock proteins in human skeletal muscle * COMMENTARY

2007 ◽  
Vol 41 (7) ◽  
pp. 453-455 ◽  
Author(s):  
Y. Ogura ◽  
H. Naito ◽  
T. Tsurukawa ◽  
N. Ichinoseki-Sekine ◽  
N. Saga ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Human Skeletal Muscle ◽  
Hyperthermia Treatment ◽  
Shock Proteins ◽  
Microwave Hyperthermia

scholarly journals Detrimental Role of Heat Shock Protein 60&70 and Toll-like Receptor 4 in Skeletal Muscle Ischaemia In Vitro

2013 ◽  
Vol 57 (5) ◽  
pp. 77S
Author(s):  
Ali Navi ◽  
Rebekah Yu ◽  
Xu Shi-Wen ◽  
Sidney Shaw ◽  
George Hamilton ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 60 ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Muscle Ischaemia

Effect of atrazine and chlorpyrifos exposure on heat shock protein response in the brain of common carp (Cyprinus carpio L.)

2013 ◽  
Vol 107 (2) ◽  
pp. 277-283 ◽  
Author(s):  
Tao Liu ◽  
Ziwei Zhang ◽  
Dechun Chen ◽  
Liangliang Wang ◽  
Haidong Yao ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Common Carp ◽  
Cyprinus Carpio ◽  
Common Carp Cyprinus Carpio ◽  
Carp Cyprinus Carpio ◽  
Protein Response ◽  
The Brain

The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity

Metabolism ◽  
2010 ◽  
Vol 59 (11) ◽  
pp. 1556-1561 ◽  
Author(s):  
Darren C. Henstridge ◽  
Josephine M. Forbes ◽  
Sally A. Penfold ◽  
Melissa F. Formosa ◽  
Sonia Dougherty ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 72 ◽  
The Relationship
Sign in / Sign up

Export Citation Format

Share Document