$$\dot{V}$$ V ˙ O2 and HR kinetics before and after International Space Station missions

2015 ◽  
Vol 116 (3) ◽  
pp. 503-511 ◽  
Author(s):  
U. Hoffmann ◽  
A. D. Moore ◽  
J. Koschate ◽  
U. Drescher
Keyword(s):  
International Space Station ◽  
Space Station ◽  
International Space ◽  
Before And After

scholarly journals Sequencing DNA, RNA and related molecules as a tool to advance space exploration

2018 ◽  
Vol 40 (6) ◽  
pp. 10-13
Author(s):  
Aaron S. Burton
Keyword(s):  
Solar System ◽  
International Space Station ◽  
Human Body ◽  
Space Exploration ◽  
Space Station ◽  
The Moon ◽  
International Space ◽  
Before And After ◽  
Harmful Organisms ◽  
New Challenges

As humans seek to return to the Moon, and eventually to Mars and beyond, new challenges must be overcome to keep astronauts safe and healthy. This includes protecting crew members from harmful organisms in their environment, treating infections that may arise, monitoring nutrition and understanding how the human body adapts to spaceflight during missions that could last multiple years. Since the International Space Station (ISS) was first occupied in 2000, crew health has been monitored with thorough check-ups before and after flight, and the collection of many samples during flight that are brought back to Earth for analysis. During longer missions to more distant solar system locales, where returning samples to Earth is no longer practical, being able to analyse samples aboard the spacecraft could be very important.

scholarly journals Cardiac and vascular responses to thigh cuffs and respiratory maneuvers on crewmembers of the International Space Station

2012 ◽  
Vol 112 (3) ◽  
pp. 454-462 ◽  
Author(s):  
Douglas R. Hamilton ◽  
Ashot E. Sargsyan ◽  
Kathleen Garcia ◽  
Douglas J. Ebert ◽  
Peggy A. Whitson ◽  
...  
Keyword(s):  
International Space Station ◽  
Vascular System ◽  
Nasal Congestion ◽  
Space Station ◽  
Control Center ◽  
International Space ◽  
Vascular Ultrasound ◽  
Fluid Redistribution ◽  
Before And After ◽  
Mueller Maneuver

Background: the transition to microgravity eliminates the hydrostatic gradients in the vascular system. The resulting fluid redistribution commonly manifests as facial edema, engorgement of the external neck veins, nasal congestion, and headache. This experiment examined the responses to modified Valsalva and Mueller maneuvers measured by cardiac and vascular ultrasound (ECHO) in a baseline steady state and under the influence of thigh occlusion cuffs available as a countermeasure device (Braslet cuffs). Methods: nine International Space Station crewmember subjects (expeditions 16–20) were examined in 15 experiment sessions 101 ± 46 days after launch (mean ± SD; 33–185). Twenty-seven cardiac and vascular parameters were obtained with/without respiratory maneuvers before and after tightening of the Braslet cuffs (162 parameter states/session). Quality of cardiac and vascular ultrasound examinations was assured through remote monitoring and guidance by investigators from the NASA Telescience Center in Houston, TX, and the Mission Control Center in Korolyov, Moscow region, Russia. Results: 14 of 81 conditions (27 parameters measured at baseline, Valsalva, and Mueller maneuver) were significantly different when the Braslet was applied. Seven of 27 parameters were found to respond differently to respiratory maneuvers depending on the presence or absence of thigh compression. Conclusions: acute application of Braslet occlusion cuffs causes lower extremity fluid sequestration and exerts commensurate measurable effects on cardiac performance in microgravity. Ultrasound techniques to measure the hemodynamic effects of thigh cuffs in combination with respiratory maneuvers may serve as an effective tool in determining the volume status of a cardiac or hemodynamically compromised patient at the “microgravity bedside.”

Human factors assessment of International Space Station (ISS) medical equipment packs

2005 ◽  
Author(s):  
Danielle Paige Smith ◽  
Vicky E. Byrne ◽  
Cynthia Hudy ◽  
Mihriban Whitmore
Keyword(s):  
Human Factors ◽  
International Space Station ◽  
Medical Equipment ◽  
Space Station ◽  
International Space

Dose Tracker Application for Collecting Medication Use Data from International Space Station Crew

2020 ◽  
Vol 91 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Virginia. E. Wotring ◽  
LaRona K. Smith
Keyword(s):  
Data Collection ◽  
International Space Station ◽  
Sleep Disturbances ◽  
Space Station ◽  
Medication Use ◽  
International Space ◽  
Flight Data ◽  
Open Questions ◽  
Share Data ◽  
Usability Feedback

INTRODUCTION: There are knowledge gaps in spaceflight pharmacology with insufficient in-flight data to inform future planning. This effort directly addressed in-mission medication use and also informed open questions regarding spaceflight-associated changes in pharmacokinetics (PK) and/or pharmacodynamics (PD).METHODS: An iOS application was designed to collect medication use information relevant for research from volunteer astronaut crewmembers: medication name, dose, dosing frequency, indication, perceived efficacy, and side effects. Leveraging the limited medication choices aboard allowed a streamlined questionnaire. There were 24 subjects approved for participation.RESULTS: Six crewmembers completed flight data collection and five completed ground data collection before NASA’s early study discontinuation. There were 5766 medication use entries, averaging 20.6 ± 8.4 entries per subject per flight week. Types of medications and their indications were similar to previous reports, with sleep disturbances and muscle/joint pain as primary drivers. Two subjects treated prolonged skin problems. Subjects also used the application in unanticipated ways: to note drug tolerance testing or medication holiday per research protocols, and to share data with flight surgeons. Subjects also provided usability feedback on application design and implementation.DISCUSSION: The volume of data collected (20.6 ± 8.4 entries per subject per flight week) is much greater than was collected previously (<12 per person per entire mission), despite user criticisms regarding app usability. It seems likely that improvements in a software-based questionnaire application could result in a robust data collection tool that astronauts find more acceptable, while simultaneously providing researchers and clinicians with useful data.Wotring VE, Smith LK. Dose tracker application for collecting medication use data from International Space Station crew. Aerosp Med Hum Perform. 2020; 91(1):41–45.

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