Morphological correlation of the functional mechanics of the abdominal wall after mesh implantation

1997 ◽  
Vol 382 (2) ◽  
pp. 87 ◽  
Author(s):  
B. Klosterhalfen ◽  
U. Klinge ◽  
U. Henze ◽  
R. Bhardwaj ◽  
J. Conze ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Mesh Implantation ◽  
Morphological Correlation

scholarly journals Physical structure and mechanical properties of knitted hernia mesh materials: A review

2017 ◽  
Vol 48 (1) ◽  
pp. 333-360 ◽  
Author(s):  
Noor Sanbhal ◽  
Linli Miao ◽  
Rui Xu ◽  
Awais Khatri ◽  
Lu Wang
Keyword(s):  
Mechanical Properties ◽  
Hernia Repair ◽  
Pore Size ◽  
Abdominal Wall ◽  
Surgical Techniques ◽  
Physical Structure ◽  
Mesh Implantation ◽  
Mesh Structure ◽  
Hernia Mesh ◽  
Small Pore

Mesh implantation for hernia repair is one of the common surgical techniques. The goal of this review is to highlight the basic requirements of mesh in order to select the most appropriate hernia mesh considering mesh type, physical properties and mechanical properties. Textile warp-knitted synthetic meshes have significantly decreased recurrence rate of hernia. Polypropylene light weight mesh with antimicrobial coating is taking attention of researchers due to its improved compliance, infection resistance, hydrophobicity, inert nature and strong material. Composite meshes have better tissue incorporation, reduced shrinkage and improved mechanical properties. The mesh porosity is an important factor to predict the biocompatibility of all meshes. Usually, large pore size meshes are better than small pore size meshes because of their flexibility, decreased shrinkage, reduced scar bridging and increased tissue ingrowth. All synthetic and composite meshes have higher strength than the human abdominal wall. Mesh type, mesh structure, mechanical properties and mesh implantation techniques are important factors for hernia repair. It is critical to understand the physical structure and mechanical properties of mesh material in relation to human abdominal wall. Moreover, mesh surface functionalization and grafting with plasma is a new development technique to enhance the loading of antimicrobial agent for the prevention of mesh infection.

Nitric oxide modulates metalloproteinase-2, collagen deposition and adhesion rate after polypropylene mesh implantation in the intra-abdominal wall

2012 ◽  
Vol 8 (1) ◽  
pp. 108-115 ◽  
Author(s):  
Ana I.S. Moretti ◽  
Francisco J.P. Souza Pinto ◽  
Vivian Cury ◽  
Marcia C. Jurado ◽  
Wagner Marcondes ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Collagen Deposition ◽  
Mesh Implantation ◽  
Adhesion Rate

scholarly journals Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

2009 ◽  
Vol 24 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Márcia Vaz ◽  
Rodrigo Ketzer Krebs ◽  
Eduardo Neubarth Trindade ◽  
Manoel Roberto Maciel Trindade
Keyword(s):  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Type I Collagen ◽  
Giant Cells ◽  
Type Iii Collagen ◽  
Type I ◽  
Mesh Implantation ◽  
Time Required ◽  
Post Implantation ◽  
Time Point

PURPOSE: This study assessed the collagen deposition and correlated it with local inflammatory responses to evaluate the length of time required for fibroplasia when polypropylene meshes are used to repair incisional abdominal wall hernias in rats. METHODS: Thirty-six male Wistar rats underwent longitudinal resection of a peritoneal and musculoaponeurotic tissue segment (3x2 cm) of the abdominal wall followed by defect reconstruction with polypropylene mesh bridging over aponeurosis. The animals were divided into 6 groups according to the time points for the analysis of fibroplasia: 1, 2, 3, 7, 21 and 30 days post-implantation. Animals were sacrificed at each time point, and the site where the polypropylene mesh was implanted was evaluated histologically to assess inflammatory response and percentage of collagen using computer-assisted videomorphometry. RESULTS: Total collagen was found at the mesh site on the 3rd day post-implantation, and increased progressively on all subsequent days up to the 21st day, when it reached its highest percentage (p<0.001). Type III collagen increased progressively from the 3rd to the 21st days, when it reached its highest percentage (p<0.001); on the 30th day, it decreased significantly (p>0.001). Type I collagen was first found between the 7th and 21st days; it reached its highest percentage on the 21st day and then remained stable until the 30th day. The type I to type III collagen ratio increased significantly and progressively up to the 30th day (p<0.001). Neutrophils were found at the mesh site from the 1st to the 21st day post-implantation. Macrophages, giant cells and lymphocytes were seen on the 2nd day. Thirty days after mesh implantation, neutrophils disappeared, but the percentages of macrophages, giant cells and lymphocytes remained stable (p<0.001). CONCLUSIONS: This study showed that total collagen was first seen on the 3rd day post-implantation, with a higher percentage of type I collagen at the last observational time point. The prolonged healing inflammatory response and the persistence of chronic inflammation surrounding to the mesh did not affect the length of time required for fibroplasia.

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