SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes

2014 ◽  
Vol 467 (6) ◽  
pp. 1227-1236 ◽  
Author(s):  
Kui-Hao Chen ◽  
Hui Liu ◽  
Lei Yang ◽  
Man-Wen Jin ◽  
Gui-Rong Li
Keyword(s):  
Ventricular Myocytes ◽  
Sodium Current ◽  
Voltage Gated ◽  
Rat Ventricular Myocytes

Tedisamil inactivates transient outward K+ current in rat ventricular myocytes

1989 ◽  
Vol 257 (5) ◽  
pp. H1746-H1749 ◽  
Author(s):  
I. D. Dukes ◽  
M. Morad
Keyword(s):  
Ventricular Myocytes ◽  
Sodium Current ◽  
Outward Current ◽  
Cell Voltage ◽  
Transient Outward Current ◽  
Dependent Manner ◽  
Rat Ventricular Myocytes ◽  
K Current ◽  
New Type ◽  
Inwardly Rectifying

The action of tedisamil, a new bradycardiac agent with antiarrhythmic properties, was investigated in single rat ventricular myocytes using the whole cell voltage-clamp technique. Under current clamp conditions, 1-20 microM tedisamil caused marked prolongations of the action potential. Over the same concentration range, in voltage-clamped myocytes, tedisamil suppressed the transient outward current (ito) and enhanced its inactivation in a dose-dependent manner. The half-maximal dose for the effect of tedisamil on ito was approximately 6 microM. Tedisamil had no significant effects on the inwardly rectifying potassium current and calcium current but did suppress the sodium current at concentrations greater than 20 microM. Our findings suggest that tedisamil represents a new type of antiarrhythmic agent that primarily suppresses the transient outward K+ current.

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