Electroacupuncture decreases inflammatory pain through a pro-resolving mechanism involving the peripheral annexin A1-formyl peptide receptor 2/ALX-opioid receptor pathway

2021 ◽  
Author(s):  
Cintia Vieira ◽  
Daiana C. Salm ◽  
Verônica V. Horewicz ◽  
Daniela D. Ludtke ◽  
Aline A. Emer ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Inflammatory Pain ◽  
Formyl Peptide Receptor ◽  
Annexin A1 ◽  
Peptide Receptor ◽  
Formyl Peptide

Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects

2008 ◽  
Vol 8 (6) ◽  
pp. 765-776 ◽  
Author(s):  
C JOHN ◽  
F GAVINS ◽  
N BUSS ◽  
P COVER ◽  
J BUCKINGHAM
Keyword(s):  
Formyl Peptide Receptor ◽  
Annexin A1 ◽  
Peptide Receptor ◽  
Formyl Peptide ◽  
Receptor Family

scholarly journals Proresolving and Tissue-Protective Actions of Annexin A1–Based Cleavage-Resistant Peptides Are Mediated by Formyl Peptide Receptor 2/Lipoxin A4 Receptor

2013 ◽  
Vol 190 (12) ◽  
pp. 6478-6487 ◽  
Author(s):  
Jesmond Dalli ◽  
Angelo P. Consalvo ◽  
Vicki Ray ◽  
Clara Di Filippo ◽  
Michele D’Amico ◽  
...  
Keyword(s):  
Formyl Peptide Receptor ◽  
Annexin A1 ◽  
Lipoxin A4 ◽  
Peptide Receptor ◽  
Protective Actions ◽  
Formyl Peptide

289 FORMYL PEPTIDE RECEPTOR LIKE‐1 (FPRL1) INVOLVEMENT IN INFLAMMATORY PAIN

2009 ◽  
Vol 13 (S1) ◽  
Author(s):  
M. Colucci ◽  
M. Mastriota ◽  
A. Giannuario ◽  
Q. Liu ◽  
H. Lu ◽  
...  
Keyword(s):  
Inflammatory Pain ◽  
Formyl Peptide Receptor ◽  
Peptide Receptor ◽  
Formyl Peptide

scholarly journals Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair

2012 ◽  
Vol 123 (1) ◽  
pp. 443-454 ◽  
Author(s):  
Giovanna Leoni ◽  
Ashfaqul Alam ◽  
Philipp-Alexander Neumann ◽  
J. David Lambeth ◽  
Guangjie Cheng ◽  
...  
Keyword(s):  
Formyl Peptide Receptor ◽  
Annexin A1 ◽  
Epithelial Repair ◽  
Peptide Receptor ◽  
Formyl Peptide

The Role of Annexin A1 and Formyl Peptide Receptor 2/3 Signaling in Chronic Corticosterone-Induced Depression-Like behaviors and Impairment in Hippocampal-Dependent Memory

2020 ◽  
Vol 19 (1) ◽  
pp. 27-43 ◽  
Author(s):  
Alessio Filippo Peritore ◽  
Rosalia Crupi ◽  
Maria Scuto ◽  
Enrico Gugliandolo ◽  
Rosalba Siracusa ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Calcium Binding ◽  
Neuronal Damage ◽  
Camp Response Element Binding ◽  
Formyl Peptide Receptor ◽  
Annexin A1 ◽  
Behavioural Disorders ◽  
Peptide Receptor ◽  
Formyl Peptide

Background: The activity of the hypothalamic-pituitary-adrenal (HPA) axis is commonly dysregulated in stress-related psychiatric disorders. Annexin A1 (ANXA1), an endogenous ligand of formyl peptide receptor (FPR) 2/3, is a member of the family of phospholipid- and calcium-binding proteins with a well-defined role in the delayed early inhibitory feedback of glucocorticoids (GC) in the pituitary gland and implicated in the occurrence of behavioural disorders such as anxiety. Objective: The present study aimed to evaluate the potential role of ANXA1 and its main receptor, as a cellular mediator of behavioural disorders, in a model of corticosterone (CORT)-induced depression and subsequently the possible correlation between the depressive state and impairment of hippocampal memory. Methods: To induce the depression model, wild-type (WT), ANXA1 knockout (KO), and FPR2/3 KO mice were exposed to orally administration of CORT for 28 days dissolved in drinking water. Histological, biochemical and behavioural analyses were performed. Results: FPR2/3 KO and ANXA1 KO mice showed improvement in anxiety and depression-like behaviour compared with WT mice after CORT administration. In addition, FPR2/3 KO and ANXA1 KO mice showed a reduction in histological alterations and neuronal death in hippocampal sections. Moreover, CORT+ FPR2/3 KO and ANXA1 KO, exhibited an higher expression of brain derived neurotrophic factor (BDNF), phospho-ERK, cAMP response element-binding protein (pCREB) and a decrease of serotonin transporter expression (SERT) compared to WT(CORT+) mice. Conclusion: In conclusion, the absence of the ANXA1 protein, even more than the absence of its main receptor (FPR 2/3), was fundamental to the inhibitory action of GC on the HPA axis; it also maintained the hippocampal homeostasis by preventing neuronal damage associated with depression.

Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets

2011 ◽  
Vol 11 (1) ◽  
pp. 55-66 ◽  
Author(s):  
Lydia Spurr ◽  
Suchita Nadkarni ◽  
Magali Pederzoli-Ribeil ◽  
Nicolas J. Goulding ◽  
Mauro Perretti ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Human Leukocyte ◽  
Formyl Peptide Receptor ◽  
Annexin A1 ◽  
Peptide Receptor ◽  
Formyl Peptide
Sign in / Sign up

Export Citation Format

Share Document