Histo-molecular characterization of pancreatic cancer with microsatellite instability: intra-tumor heterogeneity, B2M inactivation, and the importance of metastatic sites

2021 ◽  
Author(s):  
Claudio Luchini ◽  
Andrea Mafficini ◽  
Deyali Chatterjee ◽  
Maria L. Piredda ◽  
Concetta Sciammarella ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Microsatellite Instability ◽  
Molecular Characterization ◽  
Tumor Heterogeneity ◽  
Metastatic Sites

Cellular and molecular characterization of IDH1-mutated diffuse low grade gliomas reveals tumor heterogeneity and absence of EGFR/PDGFRα activation

Glia ◽  
2017 ◽  
Vol 66 (2) ◽  
pp. 239-255 ◽  
Author(s):  
S. Azar ◽  
N. Leventoux ◽  
C. Ripoll ◽  
V. Rigau ◽  
C. Gozé ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Tumor Heterogeneity ◽  
Low Grade ◽  
Low Grade Gliomas

scholarly journals Can miRNA Biomarkers Be Utilized to Improve the Evaluation and Management of Pancreatic Cystic Lesions?

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Linda S. Lee ◽  
Anna E. Szafranska-Schwarzbach ◽  
Bernard F. Andruss ◽  
Darwin L. Conwell
Keyword(s):  
Pancreatic Cancer ◽  
Early Diagnosis ◽  
Diagnostic Accuracy ◽  
Molecular Characterization ◽  
Clinical Management ◽  
Cystic Lesions ◽  
Molecular Tools ◽  
Cystic Pancreatic Lesions ◽  
Novel Therapeutic

AbstractThis article reviews the current strategies and challenges of diagnosing pancreatic cystic lesions, and presents an overview of molecular tools that are available to enhance diagnostic accuracy. Specifically, we highlight the emergence of microRNAs (miRNAs) as diagnostic markers. miRNA signatures have been reported for both solid tissue and biofluid specimens, including cyst fluid, collected from patients with solid and cystic pancreatic lesions. These miRNA signatures offer the opportunity to improve molecular characterization of pancreatic lesions, to help guide clinical management through early diagnosis and informed prognosis, and to provide novel therapeutic targets for pancreatic cancer.

scholarly journals Generation and molecular characterization of pancreatic cancer patient-derived xenografts reveals their heterologous nature

Oncotarget ◽  
2016 ◽  
Vol 7 (38) ◽  
pp. 62533-62546 ◽  
Author(s):  
Jaeyun Jung ◽  
Cue Hyunkyu Lee ◽  
Hyang Sook Seol ◽  
Yeon Sook Choi ◽  
Eunji Kim ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Patient ◽  
Molecular Characterization ◽  
Pancreatic Cancer Patient

scholarly journals Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis

2020 ◽  
Vol 59 (4) ◽  
pp. 417-426 ◽  
Author(s):  
Luís Nunes ◽  
Kristine Aasebø ◽  
Lucy Mathot ◽  
Viktor Ljungström ◽  
Per-Henrik Edqvist ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Primary Tumor ◽  
Tumor Location ◽  
Colorectal Cancers ◽  
Primary Tumor Location ◽  
Metastatic Sites ◽  
Unselected Cohort

Molecular characterization of cytotoxic and resistance mechanisms induced by NCX 4040, a novel NO-NSAID, in pancreatic cancer cell lines*

APOPTOSIS ◽  
2006 ◽  
Vol 11 (8) ◽  
pp. 1321-1330 ◽  
Author(s):  
Marco Rosetti ◽  
Anna Tesei ◽  
Paola Ulivi ◽  
Francesco Fabbri ◽  
Ivan Vannini ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Molecular Characterization ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines ◽  
Resistance Mechanisms

scholarly journals Epigenetic regulation and molecular characterization of C/EBPα in pancreatic cancer cells

2009 ◽  
Vol 124 (4) ◽  
pp. 827-833 ◽  
Author(s):  
Takashi Kumagai ◽  
Tadayuki Akagi ◽  
Julian C. Desmond ◽  
Norihiko Kawamata ◽  
Sigal Gery ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Molecular Characterization ◽  
Epigenetic Regulation ◽  
Pancreatic Cancer Cells

Molecular Characterization of Pancreatic Cancer Cell Lines

2010 ◽  
pp. 457-469 ◽  
Author(s):  
David J. McConkey ◽  
Woonyoung Choi ◽  
Keith Fournier ◽  
Lauren Marquis ◽  
Vijaya Ramachandran ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Molecular Characterization ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines

Establishment and molecular characterization of six primary pancreatic cancer cell lines

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
F Rückert ◽  
D Aust ◽  
I Böhme ◽  
HD Saeger ◽  
C Pilarsky ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Molecular Characterization ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines
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