scholarly journals Handedness and midsagittal corpus callosum morphology: a meta-analytic evaluation

2021 ◽  
Author(s):  
René Westerhausen ◽  
Marietta Papadatou-Pastou
Keyword(s):  
Corpus Callosum ◽  
Hand Preference ◽  
Left Hand ◽  
Cast Doubt ◽  
The Common ◽  
The Mean ◽  
Explained Variance ◽  
Meta Analyses ◽  
The Relationship ◽  
Population Effects

AbstractFollowing a series of seminal studies in the 1980s, left or mixed hand preference is widely thought to be associated with a larger corpus callosum than right handedness, influencing the interpretation of findings and various theories related to interhemispheric processing, brain lateralisation, and hand preference. Recent reviews, however, find inconsistencies in the literature and cast doubt on the existence of such an association. The present study was conducted to clarify the relationship between hand preference and callosal morphology in a series of meta-analyses. For this purpose, articles were identified via a search in PubMed and Web Of Science databases. Studies reporting findings relating to handedness (assessed as hand preference) and corpus-callosum morphology in healthy participants were considered eligible. On the basis of a total of k = 24 identified studies and databases, random-effects meta-analyses were conducted considering four different group comparisons: (a) dominantly right- (dRH) and left-hand preference (dLH), (b) consistent right (cRH) and non-cRH preference, (c) cRH with mixed-hand preference (MH), and (d) cRH with consistent left-hand hand preference (cLH). For none of these meta-analyses did we find a significant effect of hand preference, and narrow confidence intervals suggest that the existence of population effects larger than 1% explained variance could be excluded. For example, considering the comparison of dRH and dLH (k = 14 studies; 1910 dRH and 646 dLH participants) the mean effect size was Hedge’s g = 0.016 (95% confidence interval: − 0.12 to 0.15; explained variance: < 0.001%). Thus, the common practice of assuming an increase in callosal connectivity based on mixed or left hand preference is likely invalid.

scholarly journals Handedness and midsagittal corpus callosum morphology: A systematic meta-analytic evaluation

2021 ◽  
Author(s):  
René Westerhausen ◽  
Marietta Papadatou-Pastou
Keyword(s):  
Corpus Callosum ◽  
Web Of Science ◽  
Hand Preference ◽  
Effect Sizes ◽  
Hemispheric Processing ◽  
Left Hand ◽  
Cast Doubt ◽  
The Common ◽  
Meta Analyses ◽  
Healthy Participants

AbstractFollowing a series of seminal studies in the 1980s, left or mixed hand preference is widely considered to be associated with a larger corpus callosum, influencing the interpretation of findings and various theories related to inter-hemispheric processing, brain lateralisation, and hand preference. Recent reviews of the literature, however, report inconsistencies in the literature and cast doubt on the existence of such an association. The aim of the present study was to systematically evaluate and meta-analytically integrate the available data on the effect of hand preference on corpus-callosum morphology. For this purpose, articles were identified via a search in PubMed and Web of Science databases. Studies reporting findings relating handedness (assessed as hand preference) and corpus-callosum morphology in healthy participants were considered eligible. On the basis of a total ofk= 25 identified studies, random-effects meta-analyses were conducted considering four different group comparisons found in the literature. That is, studies comparing participants of (a) predominantly right- (dRH) and left-hand preference (dLH), (b) consistent right (cRH) and non-cRH preference, (c) cRH with mixed-hand preference (MH), and (d) cRH with consistent left-hand hand preference (cLH). For none of these meta-analyses did we find a significant effect of hand preference, and narrow confidence intervals suggest that the existence of substantial population effect sizes can be excluded. For example, considering the comparison of dRH and dLH, (summarizingk= 14 studies incorporating 1910 dRH and 646 dLH participants) the estimated mean effect size wasg= 0.016 (95% confidence interval: −0.12 to 0.15). Thus, the common practice of assuming an increase in callosal connectivity based on hand preference is likely invalid.

scholarly journals The Relationship of Digit Ratio (2D:4D) With Cerebral Lateralization and Grip Strength in Elite Swimmers

2018 ◽  
Vol 6 (4) ◽  
pp. 84
Author(s):  
Hakan Acar ◽  
Nebahat Eler
Keyword(s):  
Grip Strength ◽  
Hand Preference ◽  
Hand Grip Strength ◽  
Dominant Hand ◽  
Men And Women ◽  
Left Hand ◽  
Hand Grip ◽  
Elite Swimmers ◽  
The Relationship ◽  
Right And Left Hand

The index finger and the 4th finger ratio (2D:4D) is the indicator of the prenatal testosterone. The aim of this study is to investigate the relationship between 2D:4D, hand preference and hand grip strength in swimmers. A total of 80 elite swimmers, participated in the study. Height, body weight, body mass index (BMI), hand 2D:4D finger measurements and hand grip strength tests were performed for athletes. The hand preference was determined by the Oldfield questionnaire and it was evaluated according to the Geschwind score. The data were recorded in the SPSS 20 program and p<0.05 was considered as statistically significant. It was found that in both men and women, a negative correlation was found between right and left hand 2D:4D and both dominant (DHGS) and non-dominant hand grip strength (NDHGS) values. It was found that men had lower 2D:4D ratio than women. For both right and left handed, there was a statistically significant difference between the right and left hand 2D:4D ratios in both men and women (p<0.05) and the dominant hand (DH) 2D:4D ratios were found to be lower than non-dominant hand (NDH) 2D:4D ratios in both men and women (p<0.05)  It can be said that the 2D:4D ratios may be the effect of determining the hand preference, the grip strength and therefore the strength.

scholarly journals Analysing the relationship between nutrition and the microbial composition of the oral biofilm  - insights from the analysis of individual variability

2020 ◽  
Author(s):  
Kirstin Vach ◽  
Ali Al-Ahmad ◽  
Annette Anderson ◽  
Johan Peter Woelber ◽  
Lamprini Karygianni ◽  
...  
Keyword(s):  
Individual Variability ◽  
Oral Microbiota ◽  
Bacterial Concentration ◽  
Oral Biofilm ◽  
Microbial Composition ◽  
Mean Values ◽  
The Mean ◽  
Meta Analyses ◽  
Log Steps ◽  
The Relationship

Abstract Background: The influence of nutrition on the oral microbiota has been discussed in the literature, but usually only changes of the mean values are reported. This paper focuses on the variability of patients’ reactions. Methods: Two types of inter-individual variability in such studies and statistical models to estimate them are introduced. Through smart presentation of the estimates from the studies, a better understanding of the data can be obtained. Random effects meta-analyses are used to analyse the heterogeneity in variability across different bacteria. Results: For the nutrition individually chosen by the participants, we observed an inter-individual variability of the bacterial concentration of three log steps. Given that we found no evidence of heterogeneity in variability across different bacteria, the results can be used to offer recommendations for future studies and compute the number of cases needed. Conclusions: For studies measuring the concentration change of bacteria as a reaction to nutrition change, the use of replications and analysis of the variability is recommended.

The Relationship between Low Intraoperative Hematocrit Levels during Cardiopulmonary Bypass and Postoperative Neurological Events

2013 ◽  
Vol 16 (5) ◽  
pp. E243-E247
Author(s):  
Metin Yılmaz ◽  
Anıl Özen ◽  
Kerem Yay ◽  
Ertekin Utku Ünal ◽  
Ömer Faruk Çiçek ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Bypass Surgery ◽  
Pathological Finding ◽  
Coronary Bypass ◽  
Control Group ◽  
Open Heart ◽  
Left Hand ◽  
The Mean ◽  
The Relationship

Objective: The objective of our study is to analyzewhether low intraoperative hematocrit levels have an effectupon postoperative neurological events.Methods: Our study included 140 patients who underwentisolated coronary bypass under cardiopulmonary bypassbetween 2009 and 2012. The main group of the study was70 patients with intraoperative hematocrit levels lower than22%. These patients’ 30-day postoperative neurological (particularlystroke) follow up was registered as the main data ofthe study. Another group of 70 patients possessing the samedemographic features who underwent open heart surgerywith hematocrit levels remaining above 22% were registeredas the control group for perioperative neurological data.Results: The average age of the patients with hematocritlevels below and above 22% was 56.8 ± 5.8 years and 54.1± 7.3 years, respectively. The mean follow-up period of thepatients was 37.2 ± 8.6 days. None of the patients had anyneurological postoperative sequalae. No mortalities occurred.One patient who had mild paresthesia and motor weaknessof the left hand had no pathological finding on computedtomography and was diagnosed with peripheral neuropathydue to intraoperative sternal retraction.Conclusion: Because our study revealed no cerebrovascularevents, coronary bypass surgery under cardiopulmonarybypass may be safely conducted even in patients with hematocritlevels lower than 22%.

The relationship between 2D:4D ratio and systemizing and empathy quotients in parents of people with autism spectrum disorders

2011 ◽  
Vol 26 (S2) ◽  
pp. 1750-1750 ◽  
Author(s):  
Á. Romero-Martínez ◽  
P. Sariñana-González ◽  
J.M. Roa Natividad ◽  
M.V. Sanchis-Calatayud ◽  
S. De Andrés-García ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Control Group ◽  
Regression Analyses ◽  
Psychological Variables ◽  
Left Hand ◽  
The Mean ◽  
Spectrum Disorders ◽  
The Relationship ◽  
Psychological Dimensions

IntroductionInterdigital 2D:4D ratio has been considered as an indicator of prenatal exposure to androgens, entailing then a smaller ratio more androgenisation. Although it has been related to systemizing and empathy dimensions in the general population, it has never been studied in parents of people with Autism Spectrum Disorders (ASDs).Objectives and aimsTo analyse the relationship between the 2D:4D ratio and these psychological variables in this population.MethodsThe sample was composed by parents of both genders of people with (n = 46) or without (n = 42) ASDs. The ratio was calculated as the mean of 3 measurements of each hand evaluated by 3 different researchers. Psychological dimensions were evaluated by means of the Systemizing and Empathy Quotients (SQ and EQ, respectively).ResultsParents of ASDs persons showed lower scores in the EQ than controls, being these differences replicated only in men. No differences between groups for the 2D:4D ratio were found. Nevertheless, regression analyses indicated that in parents of ASDs a higher 2D:4D left ratio predicted a higher EQ. This result was also observed in men but not in women. In any case, the model was not significant in the control group.ConclusionsParents of ASDs persons showed lower EQ than controls, being this quotient predicted by the left 2D:4D ratio only in the former. When analysing in each gender, these results are only obtained in men. Among other parameters, the D2:D4 ratio (especially the left hand one) could be considered a valid indicator of the ASDs parent's idiosyncrasy.

Do Monkeys Choose the More Skillful Hand in Manual Problem-Solving?

1998 ◽  
Vol 87 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Masanari Kinoshita
Keyword(s):  
Problem Solving ◽  
Macaca Fuscata ◽  
Hand Preference ◽  
Left Hand ◽  
Performance Time ◽  
Japanese Monkeys ◽  
Right Hand ◽  
Manual Skills ◽  
The Relationship

To investigate the relationship between manual skills and hand preference in 4 female Japanese monkeys ( Macaca fuscata), the technique of concurrent investigation of manual skills and hand preference was introduced. 4 female Japanese monkeys were required to take food out of a pipe using the left hand and right hand alternately. The performance time and the number of deviations from alternate sequence were recorded as measure of manual skills and hand preference. In the result, the preferred hand was not always consistently the skillful one; however, only one subject tended to choose the more skillful hand in problem-solving, and another subject learned the alternate sequence of reaching. The performances of two subjects indicated discrimination of both hands in Japanese monkeys is possible.

An Anatomical Study of Morton's Interdigital Neuroma: The Relationship Between the Occurring Site and the Deep Transverse Metatarsal Ligament (DTML)

2007 ◽  
Vol 28 (9) ◽  
pp. 1007-1010 ◽  
Author(s):  
J-Young Kim ◽  
Jae Hyuck Choi ◽  
Jungmin Park ◽  
Joonho Wang ◽  
Inmook Lee
Keyword(s):  
Anterior Margin ◽  
Metatarsophalangeal Joint ◽  
Anatomical Study ◽  
Causative Factor ◽  
Metatarsal Head ◽  
Digital Nerve ◽  
Fresh Frozen ◽  
The Common ◽  
The Mean ◽  
The Relationship

Background: Using clinical and cadaver studies, we examined the relationship between the location of Morton interdigital neuromas and the surrounding structures, including the deep transverse metatarsal ligament (DTML), which has been suspected as a major causative factor in neuroma formation. Methods: Seventeen fresh-frozen cadavers were evaluated to determine the relationship between the location of Morton interdigital neuromas and the DTML at two phases of the gait cycle with 60 degrees of metatarsophalangeal dorsiflexion and with 15 degrees of ankle dorsiflexion. We measured the distance from the bifurcation of the common digital nerve in the foot to the anterior margin of the DTML and also measured the length of the DTML itself. Clinically, we checked the location of the Morton interdigital neuroma and its length during surgery in 32 feet. Results: In the second and third webspace, the mean distance from the bifurcation of the common digital nerve of the foot to the anterior margin of the DTML was 16.7 mm, 15.1 mm in the mid-stance position, and 15.9 mm and 14.6 mm in the heel-off position. The length of the second and third DTML averaged 12.8 mm and 10.6 mm. Clinically, all of the cases of Morton interdigital neuroma started at the bifurcation area of the common digital nerve, and the mean neuroma length was 7.5 mm (6 to 11). Conclusions: Morton interdigital neuromas were located more distally than the DTML in both the mid-stance and the heel-off stage during walking. The main lesion was located between the metatarsal head and the metatarsophalangeal joint and more distal than the DTML, questioning previous studies suggesting that the DTML is the major causative factor in development of Morton interdigital neuroma.

The relationship of hand preference to anatomy of the corpus callosum in men

1991 ◽  
Vol 545 (1-2) ◽  
pp. 175-182 ◽  
Author(s):  
Sandra F. Witelson ◽  
Charles H. Goldsmith
Keyword(s):  
Corpus Callosum ◽  
Hand Preference ◽  
Relationship Of ◽  
The Relationship

316 Comorbidities among medically diagnosed insomnia patients: A MarketScan database study

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A127-A127
Author(s):  
Wenjun Zhong ◽  
Xinyue Liu ◽  
Katrina Mott ◽  
Zaina Qureshi
Keyword(s):  
Claims Data ◽  
Skin Diseases ◽  
Database Analysis ◽  
High Frequencies ◽  
Diagnosis Codes ◽  
Icd 10 ◽  
Physical Disorders ◽  
The Common ◽  
The Mean ◽  
The Relationship

Abstract Introduction A large proportion of patients with insomnia frequently suffer from comorbid medical conditions. Literature on the relationship between insomnia and associated comorbidities is severely limited due to challenges of generalizability, focus on a specific comorbidity and concerns of information biases. We conducted a comprehensive secondary database analysis to describe comorbidities among medically diagnosed insomnia patients. Methods All patients in the MarketScan database in 2018 with a full year of enrollment were included. Insomnia patients were identified using ICD-10-CM diagnosis codes (at least 2 outpatient claims or 1 inpatient claim of insomnia in 2018), along with their comorbidities recorded in that year. The frequencies of comorbidities among patients with insomnia were estimated. For comorbidities with prevalence &gt; 1%, we further grouped them when appropriate to reduce the number of comorbidities. Results Among 20,209,292 enrollees, 259,035 (1.3%) had insomnia in 2018. Patients with insomnia had a median of 2 (IQR: 1–3) insomnia claims. The mean age of these insomnia patients was 49.3 years (std: 15.7), most of them were female (62.5%). About 172 comorbidities with &gt;1% were found in this patient population, and 35 comorbidities had a frequency greater than 10%. The common comorbidities among these insomnia patients included 1): common physical disorders among middle aged and older adults: hyperlipidemia (39%), hypertension (39%), skin diseases (37%), back pain 35%; 2):common mental health disorders such as anxiety disorder (41%), depression (28%); and 3): other diseases such as GERD and thyroid diseases also had high frequencies among insomnia patients (18% and 18.7%, respectively). Conclusion Using claims data, we provided a quantitative assessment of comorbidities among patients with medically diagnosed insomnia. These results could help clinicians become aware of the most frequently occurring comorbidities and assist in integrating management of the insomnia. Support (if any):

scholarly journals Better Cognitive Function Increase the Independence Level of Eldery

1970 ◽  
Vol 5 (02) ◽  
pp. 22-29
Author(s):  
Syahreza Nazhara ◽  
Maria Regina Rachmawati
Keyword(s):  
Cognitive Function ◽  
Daily Activity ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Katz Index ◽  
The Common ◽  
The Mean ◽  
Common Problems ◽  
The Relationship

Background: The number of elderly is increasing, estimated by the year of 2020 reach 28,800,000 (11.34%) ofthe total population. One of the common problems of the elderly is dependence on daily activity function andcognitive function. There is no data about the relationship between cognitive function with independence indaily activity in rthe nursing home. The objective of this study is to analyze the relationship between cognitivefunction with the level of independence on daily activity in the elderly who live in a nursing home.Methods: Study design was analytical observation by the cross-sectional study. The instruments that used inthis study was the Mini Mental Status Evaluation (MMSE) questionnaire, to measure the cognitive function,Katz index questionnaire to measure the level of independency. analyzed by Spearman correlation test.Results: The subjects were 107 elderly, the mean age was 69.7±8.7. MMSE score were 0-17 (severe), 18-23(moderate), and 24-30 (Normal), respectively were; 62 (57.9%) ,26 (24.3%),19 (17.8%). Katz Index score were02 (severe dependency), 3-5 (moderate dependency), and 6 (independence), respectively were; 8 (7,5%), 24(22,4%), 70 (70,1%). There is the positive relationship between cognitive function and the level of independencein elderly (p=0.000, r = 0.335).Conclusion: The higher cognitive function correlates with the higher independence level of elderly in nurseryhome.Keywords: cognitive function, independence level, elderly, nursery home

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