Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy

2008 ◽  
Vol 167 (12) ◽  
pp. 1369-1377 ◽  
Author(s):  
Sina Nettekoven ◽  
Alexander Ströhle ◽  
Birgit Trunz ◽  
Maike Wolters ◽  
Susanne Hoffmann ◽  
...  
Keyword(s):  
Vitamin D ◽  
Drug Therapy ◽  
Bone Turnover ◽  
Antiepileptic Drug ◽  
Biochemical Markers ◽  
Vitamin D Status ◽  
Markers Of Bone Turnover ◽  
Antiepileptic Drug Therapy

scholarly journals Vitamin D status and markers of bone turnover in Caucasian and South Asian postmenopausal women living in the UK

2010 ◽  
Vol 103 (12) ◽  
pp. 1706-1710 ◽  
Author(s):  
Nicola M. Lowe ◽  
Soma R. Mitra ◽  
Peter C. Foster ◽  
Issak Bhojani ◽  
John F. McCann
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
South Asian ◽  
Bone Quality ◽  
Biochemical Markers ◽  
Vitamin D Status ◽  
Amino Terminal ◽  
Markers Of Bone Turnover ◽  
Serum Pth

Suboptimal vitamin D status among the South Asian UK population is widely reported; however, its impact on bone health is unclear. The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality. A cross-sectional study of community-dwelling women aged 50–66 years was carried out. A total of sixty-six SA women of Pakistani origin and forty-two C women living in the same community were recruited. Fasting blood was taken for the measurement of vitamin D, PTH and biochemical markers of bone turnover, including type-1 collagen β C-telopeptide (βCTX), procollagen type-1 amino-terminal propeptide (P1NP), and bone-specific alkaline phosphatase (BAP) activity. Bone quality was assessed using broadband ultrasound attenuation (BUA). Total serum 25-hydroxyvitamin D (25(OH)D) was significantly lower in the SA women than the C women (medians: SA 10·5 v. C 47·1 nmol/l; P < 0·001) This was associated with a significantly elevated serum PTH concentration in the SA group (medians: SA 7·3 v. C 4·5 pmol/l; P < 0·01). BAP activity was also significantly higher in the SA group, indicating elevated osteoblast activity and bone turnover (medians: SA 23·0 v. C 20·0 U/l; P < 0·05). No significant differences were observed between the two groups for P1NP, βCTX or BUA. Although the SA women had significantly higher serum PTH and lower 25(OH)D concentrations than C women, this was not associated with significantly higher markers of bone resorption, or reduced bone quality in the SA women.

scholarly journals Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents

2004 ◽  
Vol 58 (9) ◽  
pp. 1257-1265 ◽  
Author(s):  
F Ginty ◽  
C Cavadini ◽  
P-A Michaud ◽  
P Burckhardt ◽  
M Baumgartner ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Nutrient Intake ◽  
Vitamin D Status ◽  
Markers Of Bone Turnover

scholarly journals Bone mineral density in children with long-term antiepileptic therapy

2013 ◽  
Vol 141 (5-6) ◽  
pp. 329-332 ◽  
Author(s):  
Milena Dimic ◽  
Aleksandar Dimic ◽  
Zoran Milosevic ◽  
Jelena Vojinovic
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Bone Mineral ◽  
Control Group ◽  
Mineral Density ◽  
Antiepileptic Therapy ◽  
Epileptic Children ◽  
Antiepileptic Drug Therapy

Introduction. Vitamin D active metabolites deficit that is altered by negative calcium and phosphorus balance is a potential complication during long?term antiepileptic drug therapy. Objective. The aim of this study was to examine lumbar bone mineral density (BMD) in epileptic children receiving antiepileptic drug therapy longer than one year. methods. The examined sample consisted of 34 epileptic children, 18 male and 16 female, aged 6?12 (9.77?2.01) years, treated with carbamazepine, valproate, phenobarbital, lamotrigine or their combination without vitamin D supplementation. The lumbar spine BMD (L1?L4) was estimated by a Lunar densitometer and obtained results were compared with results of 35 matched population of healthy children from the control group. results. Lumbar BMD Z?score was significantly lower in female patients treated with antiepileptic therapy compared with those in the control group (?1.048?1.35 vs. ?0.399?0.518; p=0.03). Bone mineral density Z?score decrease of both gender groups receiving antiepileptic polytherapy was significantly lower compared to the control group (?1.153?0.938 vs. ?0.043?0.815; p=0.007). Therapy duration had no influence on the lumbar BMD level decrease either in boys (rxy=0.33; p=0.174) or in girls (rxy=0.02; p=0.935) treated with antiepileptic therapy. Conclusion. Our results have indicated that antiepileptic drug therapy usage longer than one year can have adverse affects on the lumbar spine BMD (L1?L4) in epileptic children, and that prophylactic vitamin D supplementation is also necessary in these patients.

The Effects of Regular Tanning Bed Use and Increased Vitamin D Status on Serum Markers of Bone Turnover in Healthy Adult Women

2009 ◽  
Vol 2 ◽  
pp. CMWH.S2031
Author(s):  
Catherine A. Peterson ◽  
Mary E. Heffernan ◽  
Kay A. Sisk ◽  
Susan M. Ring
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Type I ◽  
Adult Women ◽  
Uvb Radiation ◽  
Vitamin D Status ◽  
Tanning Beds ◽  
Healthy Women ◽  
Markers Of Bone Turnover ◽  
Uvb Exposure

Background Vitamin D is a key nutrient in bone health and the vitamin D status of individuals with regular exposure to solar or artificial ultraviolet B (UVB) radiation is generally superior to those with limited exposure. Objective By means of a cross-sectional, observational design, explore the association of serum 25-hydroxy vitamin D (25(OH)D) concentrations and biochemical markers of bone turnover across a spectrum of vitamin D status by comparing women who regularly use tanning beds with women of minimal UVB exposure. Methods A total of 69 healthy women, ages 25–82 y, were recruited. Serum concentrations of 25(OH)D, intact parathyroid hormone (iPTH), leptin, bone-specific alkaline phosphatase (BAP), osteocalcin (OC), and C-terminal telopeptides of Type I collagen (CTx) were measured. Results There were no significant differences in age, height, weight, BMI and dietary intakes between groups. Serum 25(OH)D concentrations were significantly higher in tanners (n = 20) compared with non-tanners (n = 49) (p < 0.0001). Serum iPTH concentrations were lower in tanners than in non-tanners (p < 0.0001) and were negatively correlated with serum 25(OH)D concentrations (r = –4571, p < 0.0001). Of the bone turnover markers, only serum OC concentrations were lower in tanners compared with non-tanners (p = 0.0002). After adjusting for age and menopausal status, osteocalcin was negatively correlated (r = –0.0178; p = 0.04) with 25(OH)D and positively correlated with iPTH (r = 0.035; p = 0.05). Conclusions Our results show healthy women with regular UVB exposure via tanning beds have significantly greater vitamin D status and lower serum osteocalcin concentrations than those without and that there is a significant inverse relationship between serum serum 25(OH)D and osteocalcin concentrations which appears to be PTH-dependent.

scholarly journals Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women

2018 ◽  
Vol 56 (212) ◽  
pp. 754-758 ◽  
Author(s):  
Bikram Khadka ◽  
Mohan Lal Tiwari ◽  
Ravi Gautam ◽  
Binod Timalsina ◽  
Nandu Prasad Pathak ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Inorganic Phosphorus ◽  
Menopausal Women ◽  
Markers Of Bone Turnover ◽  
Post Menopausal ◽  
Year Since Menopause

Introduction: Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important of research in low income country like Nepal.  Methods: A hospital-based cross-sectional study conducted during the period of November 2016 to December 2017 among 354 women. Blood samples for calcium, inorganic phosphorus, alkaline phosphatase and vitamin D were collected and analyzed using a validated and calibrated tools. Data were analyzed using Statistical Package for the Social Sciences software version 20. Results: Mean±Standard deviation of age of post-menopausal women was significantly higher compared to pre-menopausal women (post-menopausal women, (57.98±8.08) vs. pre-menopausal, (31.35±5.83), (P<0.001). Selected biochemical markers of bone-turnover such as alkaline phosphatase levels were significantly higher with year since menopause (P<0.001), whereas serum calcium, and vitamin D were decreasing with year since menopause among post-menopausal women. In addition, calcium and vitamin D were significantly negatively correlated with year since menopause (P<0.01) while body mass index, inorganic phosphorus and alkaline phosphatase were significantly positively correlated with year since menopause (P<0.01). Conclusions: Our study revealed that body mass index, inorganic phosphorus and alkaline phosphatase positively correlated with year since menopause while calcium and vitamin D were negatively correlated suggesting for a medical supervision of hormonal changes and periodic dosing of calcium and vitamin D among post-menopausal women to reduce the problem of bone health.

scholarly journals The Effect of Antiepileptic Drug Therapy on Bone Metabolism and its Relationship with Vitamin D Receptor Gene

2019 ◽  
Vol 28 (3) ◽  
pp. 121-127
Author(s):  
Özlem ÖZCANLI ÇAY ◽  
Hepsen Mine SERİN ◽  
Zehra Pınar KOÇ ◽  
Deniz EROL ◽  
Erdal YILMAZ
Keyword(s):  
Vitamin D ◽  
Drug Therapy ◽  
Antiepileptic Drug ◽  
Bone Metabolism ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Antiepileptic Drug Therapy
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