The Effects of Regular Tanning Bed Use and Increased Vitamin D Status on Serum Markers of Bone Turnover in Healthy Adult Women

Background Vitamin D is a key nutrient in bone health and the vitamin D status of individuals with regular exposure to solar or artificial ultraviolet B (UVB) radiation is generally superior to those with limited exposure. Objective By means of a cross-sectional, observational design, explore the association of serum 25-hydroxy vitamin D (25(OH)D) concentrations and biochemical markers of bone turnover across a spectrum of vitamin D status by comparing women who regularly use tanning beds with women of minimal UVB exposure. Methods A total of 69 healthy women, ages 25–82 y, were recruited. Serum concentrations of 25(OH)D, intact parathyroid hormone (iPTH), leptin, bone-specific alkaline phosphatase (BAP), osteocalcin (OC), and C-terminal telopeptides of Type I collagen (CTx) were measured. Results There were no significant differences in age, height, weight, BMI and dietary intakes between groups. Serum 25(OH)D concentrations were significantly higher in tanners (n = 20) compared with non-tanners (n = 49) (p < 0.0001). Serum iPTH concentrations were lower in tanners than in non-tanners (p < 0.0001) and were negatively correlated with serum 25(OH)D concentrations (r = –4571, p < 0.0001). Of the bone turnover markers, only serum OC concentrations were lower in tanners compared with non-tanners (p = 0.0002). After adjusting for age and menopausal status, osteocalcin was negatively correlated (r = –0.0178; p = 0.04) with 25(OH)D and positively correlated with iPTH (r = 0.035; p = 0.05). Conclusions Our results show healthy women with regular UVB exposure via tanning beds have significantly greater vitamin D status and lower serum osteocalcin concentrations than those without and that there is a significant inverse relationship between serum serum 25(OH)D and osteocalcin concentrations which appears to be PTH-dependent.

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Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents

European Journal of Clinical Nutrition ◽

10.1038/sj.ejcn.1601959 ◽

2004 ◽

Vol 58 (9) ◽

pp. 1257-1265 ◽

Cited By ~ 43

Author(s):

F Ginty ◽

C Cavadini ◽

P-A Michaud ◽

P Burckhardt ◽

M Baumgartner ◽

...

Keyword(s):

Vitamin D ◽

Bone Turnover ◽

Nutrient Intake ◽

Vitamin D Status ◽

Markers Of Bone Turnover

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Serum 25(OH)D3 vitamin status of elderly Finnish women is suboptimal even after summer sunshine but is not associated with bone density or turnover

Acta Endocrinologica ◽

10.1530/eje-09-0739 ◽

2010 ◽

Vol 162 (1) ◽

pp. 183-189 ◽

Cited By ~ 11

Author(s):

Tuula Pekkarinen ◽

Ursula Turpeinen ◽

Esa Hämäläinen ◽

Eliisa Löyttyniemi ◽

Henrik Alfthan ◽

...

Keyword(s):

Vitamin D ◽

Bone Density ◽

Bone Turnover ◽

Population Based ◽

Type I ◽

Vitamin D Status ◽

Mineral Density ◽

Type I Procollagen ◽

Before And After ◽

Before And After Summer

ObjectiveConcentrations of 50 and 75 nmol/l are proposed as serum 25-hydroxyvitamin D (25(OH)D) target for older people from the view of bone health. We evaluated vitamin D status of elderly Finnish women in light of these definitions, its relationship to bone mineral density (BMD) and turnover, and improvement by summer sunshine.DesignPopulation-based study.MethodsA total of 1604 ambulatory women aged 62–79 years were studied; 66% used vitamin D supplements. Serum 25(OH)D3was measured with HPLC before and after summer, and heel BMD in spring. In subgroups, serum parathyroid hormone (PTH) and type I procollagen aminoterminal propeptide (PINP) were analyzed.ResultsIn spring, 60.3% of the women had 25(OH)D3≤50 nmol/l, and the target of 75 nmol/l was reached by 9.1%. For supplement users, the respective numbers were 52.1 and 11.9%. Serum 25(OH)D3did not determine BMD or bone turnover measured by serum PINP. Summer sunshine increased serum 25(OH)D3by 17.4% (P<0.0001), but in autumn 84% of the subjects remained under the target of 75 nmol/l. In supplement users, PTH remained stable but decreased in others during summer (P=0.025).ConclusionsVitamin D status of elderly Finnish women is suboptimal if 25(OH)D3levels of 50 or 75 nmol/l are used as a threshold. It is moderately increased by supplement intake and summer sunshine. However, 25(OH)D3concentrations did not influence bone density in terms of serum PINP and bone turnover rate.

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Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy

European Journal of Pediatrics ◽

10.1007/s00431-008-0672-7 ◽

2008 ◽

Vol 167 (12) ◽

pp. 1369-1377 ◽

Cited By ~ 57

Author(s):

Sina Nettekoven ◽

Alexander Ströhle ◽

Birgit Trunz ◽

Maike Wolters ◽

Susanne Hoffmann ◽

...

Keyword(s):

Vitamin D ◽

Drug Therapy ◽

Bone Turnover ◽

Antiepileptic Drug ◽

Biochemical Markers ◽

Vitamin D Status ◽

Markers Of Bone Turnover ◽

Antiepileptic Drug Therapy

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High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1500909112 ◽

2015 ◽

Vol 112 (26) ◽

pp. 8052-8057 ◽

Cited By ~ 33

Author(s):

Anna K. Coussens ◽

Celeste E. Naude ◽

Rene Goliath ◽

George Chaplin ◽

Robert J. Wilkinson ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Low Cost ◽

Seasonal Pattern ◽

Cape Town ◽

High Dose ◽

Uvb Radiation ◽

Vitamin D Status ◽

Uvb Exposure ◽

Hiv 1

Cape Town, South Africa, has a seasonal pattern of UVB radiation and a predominantly dark-skinned urban population who suffer high HIV-1 prevalence. This coexistent environmental and phenotypic scenario puts residents at risk for vitamin D deficiency, which may potentiate HIV-1 disease progression. We conducted a longitudinal study in two ethnically distinct groups of healthy young adults in Cape Town, supplemented with vitamin D3 in winter, to determine whether vitamin D status modifies the response to HIV-1 infection and to identify the major determinants of vitamin D status (UVB exposure, diet, pigmentation, and genetics). Vitamin D deficiency was observed in the majority of subjects in winter and in a proportion of individuals in summer, was highly correlated with UVB exposure, and was associated with greater HIV-1 replication in peripheral blood cells. High-dosage oral vitamin D3 supplementation attenuated HIV-1 replication, increased circulating leukocytes, and reversed winter-associated anemia. Vitamin D3 therefore presents as a low-cost supplementation to improve HIV-associated immunity.

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Maternal and Cord Blood Concentrations of Biochemical Markers of Bone Turnover - Relationship to Maternal Vitamin D Status 1540

Pediatric Research ◽

10.1203/00006450-199804001-01562 ◽

1998 ◽

Vol 43 ◽

pp. 263-263

Author(s):

Yen-Ning Lau ◽

William Fraser

Keyword(s):

Vitamin D ◽

Bone Turnover ◽

Cord Blood ◽

Biochemical Markers ◽

Vitamin D Status ◽

Blood Concentrations ◽

Maternal Vitamin ◽

Markers Of Bone Turnover ◽

Maternal Vitamin D Status

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Vitamin D status and markers of bone turnover in Caucasian and South Asian postmenopausal women living in the UK

British Journal Of Nutrition ◽

10.1017/s0007114509993850 ◽

2010 ◽

Vol 103 (12) ◽

pp. 1706-1710 ◽

Cited By ~ 29

Author(s):

Nicola M. Lowe ◽

Soma R. Mitra ◽

Peter C. Foster ◽

Issak Bhojani ◽

John F. McCann

Keyword(s):

Vitamin D ◽

Bone Turnover ◽

South Asian ◽

Bone Quality ◽

Biochemical Markers ◽

Vitamin D Status ◽

Amino Terminal ◽

Markers Of Bone Turnover ◽

Serum Pth

Suboptimal vitamin D status among the South Asian UK population is widely reported; however, its impact on bone health is unclear. The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality. A cross-sectional study of community-dwelling women aged 50–66 years was carried out. A total of sixty-six SA women of Pakistani origin and forty-two C women living in the same community were recruited. Fasting blood was taken for the measurement of vitamin D, PTH and biochemical markers of bone turnover, including type-1 collagen β C-telopeptide (βCTX), procollagen type-1 amino-terminal propeptide (P1NP), and bone-specific alkaline phosphatase (BAP) activity. Bone quality was assessed using broadband ultrasound attenuation (BUA). Total serum 25-hydroxyvitamin D (25(OH)D) was significantly lower in the SA women than the C women (medians: SA 10·5 v. C 47·1 nmol/l; P < 0·001) This was associated with a significantly elevated serum PTH concentration in the SA group (medians: SA 7·3 v. C 4·5 pmol/l; P < 0·01). BAP activity was also significantly higher in the SA group, indicating elevated osteoblast activity and bone turnover (medians: SA 23·0 v. C 20·0 U/l; P < 0·05). No significant differences were observed between the two groups for P1NP, βCTX or BUA. Although the SA women had significantly higher serum PTH and lower 25(OH)D concentrations than C women, this was not associated with significantly higher markers of bone resorption, or reduced bone quality in the SA women.

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Bone mineral density, bone turnover and vitamin D status in women with diabetes mellitus type 2 and healthy women with osteoporosis in menopause

Endocrine Abstracts ◽

10.1530/endoabs.35.p87 ◽

2014 ◽

Author(s):

Jovanka Novakovic-Paro ◽

Ivana Bajkin ◽

Dragana Tomic-Naglic ◽

Milena Mitrovic ◽

Tijana Icin ◽

...

Keyword(s):

Diabetes Mellitus ◽

Bone Mineral Density ◽

Vitamin D ◽

Bone Turnover ◽

Bone Mineral ◽

Diabetes Mellitus Type 2 ◽

Diabetes Mellitus Type ◽

Vitamin D Status ◽

Mineral Density

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Serum levels of bone formation and resorption markers in relation to vitamin D status in professional gymnastics and physically active men during upper and lower body high-intensity exercise

Journal of the International Society of Sports Nutrition ◽

10.1186/s12970-021-00430-8 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Jan Mieszkowski ◽

Andrzej Kochanowicz ◽

Elżbieta Piskorska ◽

Bartłomiej Niespodziński ◽

Joanna Siódmiak ◽

...

Keyword(s):

Vitamin D ◽

Bone Formation ◽

Bone Turnover ◽

Bone Turnover Markers ◽

Type I Collagen ◽

Serum Levels ◽

Type I ◽

Vitamin D Metabolites ◽

Physically Active ◽

Turnover Markers

Abstract Purpose/introduction To compare serum levels of bone turnover markers in athletes and non-athletes, and to evaluate the relationship between serum levels of vitamin D metabolites and exercise-induced changes in biomarker levels. Methods Sixteen elite male artistic gymnasts (EG; 21.4 ± 0.8 years-old) and 16 physically active men (the control group, PAM; 20.9 ± 1.2 years-old) performed lower and upper body 30-s Wingate anaerobic tests (LBWT and UBWT, respectively). For biomarker analysis, blood samples were collected before, and 5 and 30 min after exercise. Samples for vitamin D levels were collected before exercise. N-terminal propeptide of type I collagen (PINP) was analysed as a marker of bone formation. C-terminal telopeptide of type I collagen (CTX) was analysed as a marker of bone resorption. Results UBWT fitness readings were better in the EG group than in the PAM group, with no difference in LBWT readings between the groups. UBWT mean power was 8.8% higher in subjects with 25(OH)D3 levels over 22.50 ng/ml and in those with 24,25(OH)2D3 levels over 1.27 ng/ml. Serum CTX levels increased after both tests in the PAM group, with no change in the EG group. PINP levels did not change in either group; however, in PAM subjects with 25(OH)D3 levels above the median, they were higher than those in EG subjects. Conclusion Vitamin D metabolites affect the anaerobic performance and bone turnover markers at rest and after exercise. Further, adaptation to physical activity modulates the effect of anaerobic exercise on bone metabolism markers.

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