Maternal blood leptin concentration in small for gestational age: a meta-analysis

Background: Adiponectin, which may have a growth-promoting effect through its insulin-sensitizing action, is thought to play a key role in fetal growth. This study was performed to determine whether maternal and/or cord blood adiponectin concentrations differ between small for gestational age (SGA) and healthy controls. Methods: Databases were searched to identify good quality English language studies providing the number of SGA and healthy controls, and the means and standard deviations of maternal or cord blood adiponectin concentration in both groups. A meta-analysis was performed to summarize the standardized mean differences (SMDs) in maternal and cord blood adiponectin concentrations between SGA and healthy controls. Results: There was no statistically significant difference in maternal blood adiponectin concentration between SGA and healthy controls (n = 8, p = 0.951). However, cord blood adiponectin concentration was significantly lower in SGA than in healthy controls (n = 6, p = 0.028), and the effect was large (i.e., SMD >0.7). Conclusions: Maternal blood adiponectin concentration is not low in SGA compared with healthy controls. However, SGA shows lower cord blood adiponectin concentration than healthy controls.

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Association of maternal blood lead concentration with the risk of small for gestational age: A dose-response meta-analysis

Archives of Environmental & Occupational Health ◽

10.1080/19338244.2021.1874857 ◽

2021 ◽

pp. 1-9

Author(s):

Ahmad Habibian Sezavar ◽

Bahman Pourhassan ◽

Nader Rahimi Kakavandi ◽

Mohammad Reza Hooshangi Shayeste ◽

Morteza Abyadeh

Keyword(s):

Dose Response ◽

Gestational Age ◽

Small For Gestational Age ◽

Lead Concentration ◽

Meta Analysis ◽

Blood Lead ◽

Maternal Blood ◽

Blood Lead Concentration

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Premature birth, low birth weight, small for gestational age and chronic non-communicable diseases in adult life: A systematic review with meta-analysis

Early Human Development ◽

10.1016/j.earlhumdev.2020.105154 ◽

2020 ◽

Vol 149 ◽

pp. 105154 ◽

Cited By ~ 4

Author(s):

Elaine Luiza Santos Soares de Mendonça ◽

Mateus de Lima Macêna ◽

Nassib Bezerra Bueno ◽

Alane Cabral Menezes de Oliveira ◽

Carolina Santos Mello

Keyword(s):

Systematic Review ◽

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Small For Gestational Age ◽

Premature Birth ◽

Meta Analysis ◽

Adult Life ◽

Communicable Diseases ◽

Non Communicable Diseases

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Children Born with Congenital Heart Defects and Growth Restriction at Birth: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17093056 ◽

2020 ◽

Vol 17 (9) ◽

pp. 3056 ◽

Cited By ~ 1

Author(s):

Ali Ghanchi ◽

Neil Derridj ◽

Damien Bonnet ◽

Nathalie Bertille ◽

Laurent J. Salomon ◽

...

Keyword(s):

Systematic Review ◽

Congenital Heart Defects ◽

Gestational Age ◽

Small For Gestational Age ◽

Congenital Heart ◽

Heart Defects ◽

Data Extraction ◽

Meta Analysis ◽

Adverse Outcomes ◽

Growth Restriction

Newborns with congenital heart defects tend to have a higher risk of growth restriction, which can be an independent risk factor for adverse outcomes. To date, a systematic review of the relation between congenital heart defects (CHD) and growth restriction at birth, most commonly estimated by its imperfect proxy small for gestational age (SGA), has not been conducted. Objective: To conduct a systematic review and meta-analysis to estimate the proportion of children born with CHD that are small for gestational age (SGA). Methods: The search was carried out from inception until 31 March 2019 on Pubmed and Embase databases. Studies were screened and selected by two independent reviewers who used a predetermined data extraction form to obtain data from studies. Bias was assessed using the Critical Appraisal Skills Programme (CASP) checklist. The database search identified 1783 potentially relevant publications, of which 38 studies were found to be relevant to the study question. A total of 18 studies contained sufficient data for a meta-analysis, which was done using a random effects model. Results: The pooled proportion of SGA in all CHD was 20% (95% CI 16%–24%) and 14% (95% CI 13%–16%) for isolated CHD. Proportion of SGA varied across different CHD ranging from 30% (95% CI 24%–37%) for Tetralogy of Fallot to 12% (95% CI 7%–18%) for isolated atrial septal defect. The majority of studies included in the meta-analysis were population-based studies published after 2010. Conclusion: The overall proportion of SGA in all CHD was 2-fold higher whereas for isolated CHD, 1.4-fold higher than the expected proportion in the general population. Although few studies have looked at SGA for different subtypes of CHD, the observed variability of SGA by subtypes suggests that growth restriction at birth in CHD may be due to different pathophysiological mechanisms.

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