Serum albumin level is associated with mycophenolic acid concentration in children with idiopathic nephrotic syndrome

2021 ◽  
Author(s):  
Tatsuya Nishimura ◽  
Osamu Uemura ◽  
Satoshi Hibino ◽  
Kazuki Tanaka ◽  
Ryoichi Kitagata ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Acid Concentration ◽  
Mycophenolic Acid ◽  
Serum Albumin Level ◽  
Idiopathic Nephrotic Syndrome ◽  
Albumin Level

Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndrome

2011 ◽  
Vol 16 (3) ◽  
pp. 411-414 ◽  
Author(s):  
Kazunari Kaneko ◽  
Takahisa Kimata ◽  
Shoji Tsuji ◽  
Tomohiko Shimo ◽  
Masaya Takahashi ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Idiopathic Nephrotic Syndrome ◽  
Albumin Level

scholarly journals Relation between Renal Resistive Index and Serum Albumin in Nephrotic Syndrome

2021 ◽  
Vol 10 (30) ◽  
pp. 2228-2232
Author(s):  
Pranoy Dey ◽  
Niku Hage
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Left Kidney ◽  
Peak Systolic Velocity ◽  
Resistive Index ◽  
Albumin Level ◽  
Renal Resistive Index ◽  
The Mean ◽  
Renal Doppler

BACKGROUND Renal resistive index (RRI) is a non-invasive marker of renal function, which can be measured by renal USG Doppler. High RI indicates poor prognosis, which has been associated with conditions such as proteinuria, hypertension, chronic kidney disease and renal failure. As nephrotic syndrome is characterised by significant proteinuria and hypoalbuminemia, which may progress to renal failure, it is important to see the correlation of RRI with serum albumin level. The purpose of this study was to assess the relation between renal resistive index and serum albumin in nephrotic syndrome. METHODS USG renal Doppler was done for all the children with nephrotic syndrome and RRI was calculated as [(peak - systolic velocity − end - diastolic velocity) / peak - systolic velocity]. Blood investigations were also done, from which serum albumin values were obtained. RRI was compared with mean serum albumin level. Statistical analysis of data was performed using the computer programme, Statistical Package for Social Sciences (SPSS for windows, version 21.01, Chicago, SPSS Inc.) and Microsoft excel 2010. Results on continuous measurement were presented as mean ± standard deviation and compared using Analysis of Variance (ANOVA). RESULTS The mean serum albumin in the children with nephrotic syndrome in our study was 1.82 ± 0.32 gm / dl. The mean RI value was 0.66 ± 0.14 SD, 0.64 ± 0.15 SD and 0.66 ± 0.12 SD as well as 0.63 ± 0.12 SD, 0.67 ± 0.16 SD and 0.71 ± 0.13 SD on the right and left kidney respectively for each of upper, middle, and lower pole. P value of left kidney and right kidney was 0.0057 and 0.6409 respectively. CONCLUSIONS Lower the mean serum albumin level, higher the range of RRI. KEY WORDS Serum Albumin, Renal Resistive Index, Nephrotic Syndrome, USG Renal Doppler

scholarly journals Correlation of serum level of albumin with platelet count and platelet aggregation assessed by adenosine diphosphate agonist in children with nephrotic syndrome

2019 ◽  
Vol 59 (1) ◽  
pp. 7-12
Author(s):  
Andar Laura Nainggolan ◽  
Sri Sudarwati ◽  
Dany Hilmanto
Keyword(s):  
Nephrotic Syndrome ◽  
Platelet Count ◽  
Platelet Aggregation ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Pediatric Nephrology ◽  
Correlation Coefficients ◽  
Adenosine Diphosphate ◽  
Albumin Level ◽  
Cross Sectional

Background Nephrotic syndrome (NS) is the most common renal disease among children, and contributes to life-threatening complications such as thromboembolic disease. Platelets are considered to be important agents in thrombotic events among NS patients. The gold standard assessment for platelet aggregation is the use of adenosine diphosphate (ADP) agonist, however, it is expensive and not accessible in smaller health facilities. Thus, other thrombosis parameters are needed. Previous studies suggested that low albumin increased the risk of thrombosis in NS patients. Objective To assess for a possible correlation between albumin level and platelet count as well as platelet aggregation. Methods This cross-sectional study was conducted in children with nephrotic syndrome who were admitted to the Pediatric Nephrology Department in Dr. Hasan Sadikin General Hospital, Bandung, West Java, from November 2017 to March 2018. Subjects were selected by consecutive sampling. Serum albumin, platelet count, and platelet aggregation were measured. Statistical analysis was conducted by Spearman’s test. Results A total of 32 patients participated in the study, with mean age of 109 (SD 7.4) months. Most subjects were male (56%). Subjects’ mean serum albumin level was 2.06 (SD 1.23) g/dL; mean platelet count was 453,062.5 (SD 187,443.90)/mm3; and mean platelet aggregation values for ADP agonist concentrations of 10, 5, 2.5, and 1 mM were 86.8 (SD 8.63)%, 82.4 (SD 15.33)%, 66.6 (SD 24.90)%, 34.95 (SD 31.69)%, respectively. Partial correlation analysis revealed significant negative associations between albumin and platelet count as well as platelet aggregation assessed with 1 mM of ADP concentration (P<0.001), with Spearman correlation coefficients of -0.641 and -0.634, respectively. Conclusion Serum albumin level had a moderately negative correlation with platelet count and platelet aggregation value.

scholarly journals Association of serum albumin level and venous thromboembolic events in a large cohort of patients with nephrotic syndrome

2017 ◽  
Vol 32 (1) ◽  
pp. 157-164 ◽  
Author(s):  
Geeta Gyamlani ◽  
Miklos Z. Molnar ◽  
Jun L. Lu ◽  
Keiichi Sumida ◽  
Kamyar Kalantar-Zadeh ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Large Cohort ◽  
Thromboembolic Events ◽  
Venous Thromboembolic Events ◽  
Venous Thromboembolic

scholarly journals Subclinical hypothyroidism in pediatric nephrotic syndrome: the correlations with albumin, globulin, and proteinuria

2020 ◽  
Vol 60 (2) ◽  
pp. 90-4
Author(s):  
Erni Nuraeni ◽  
Faiisal Faisal ◽  
Ahmedz Widiasta ◽  
Novina Novina
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Subclinical Hypothyroidism ◽  
Serum Albumin Level ◽  
Cross Sectional Study ◽  
Albumin Level ◽  
Thyroid Stimulating Hormone ◽  
Hormone Deficiency ◽  
Cross Sectional ◽  
Univariate Logistic Regression Analysis

Background Nephrotic syndrome causes loss of medium-sized plasma proteins and binding proteins, resulting in thyroid hormone deficiency. Objective To assess for potential correlations between subclinical hypothyroidism in pediatric nephrotic syndrome with albumin, globulin, and proteinuria. Methods This cross-sectional study was conducted in the Department of Pediatrics, Hasan Sadikin General Hospital, Bandung, West Java. All types of nephrotic syndrome patients aged 1 month to < 18 years were included. Blood and urine specimens were collected from the patients for albumin, globulin, thyroid function (T3, fT4 and TSH), and proteinuria tests and analyzed with standard techniques. Results There were 26 subjects, 20 males and 6 females. Ten subjects developed subclinical hypothyroidism, with mean albumin and thyroid-stimulating hormone (TSH) levels of 0.92 g/dL and 6.9 mIU/L, respectively. There was a negative correlation between albumin level and subclinical hypothyroidism (rpb=-0.702; P<0.001) and a positive correlation between proteinuria and subclinical hypothyroidism (r=0.573; P=0.003). Univariate logistic regression analysis revealed that globulin had no impact on the presence of subclinical hypothyroidism, but albumin and proteinuria did have such an impact. The odds ratios of albumin and proteinuria with subclinical hypothyroidism were 27.00 (95%CI 1.69 to 17.7) and 19.80 (95%CI 1.94 to 201.63), respectively. Conclusion Subclinical hypothyroidism correlates with serum albumin level and proteinuria in nephrotic syndrome patients. Tha low serum albumin level has a high likelihood of subclinical hypothyroidism.  

scholarly journals Relationship between ionized calcium and serum albumin level in children with idiopathic nephrotic syndrome

2016 ◽  
Vol 50 (6) ◽  
pp. 361
Author(s):  
Viiola Irene Winata ◽  
Dida Akhmad Gurnida ◽  
Nanan Sekarwana
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Calcium Level ◽  
Serum Albumin Level ◽  
Pearson Correlation ◽  
Health Department ◽  
Albumin Level ◽  
Ionized Calcium ◽  
Healthy Children ◽  
Cross Sectional

Background Nephrotic syndrome (NS) patients frequently have abnormalities in calcium metabolism that manifest as hypocalcemia and reduced intestinal absorption of calcium. Hypocalcemia is initially attributed to hypoalbuminemia but it may also relate to a low level of ionized calcium. The ionized calcium level depends on the severity and duration of proteinuria.Objective To assess the rel ationship between ionized calcium and serum albumin level in idiopathic NS children.Methods An analytical study with cross-sectional design was applied to NS and healthy children between 1-14 years old in the Child Health Department of Hasan Sadikin Hospital, Bandung from December 2009 to April 2010. Ionized calcium was examined by Ca2 + analyzer AVL 980 with ion-selective electrodes (ISE) methods.Results A total of34 subjects were recruited, consist of 17 NS and 17 healthy children. The mean ionized calcium and serum albumin level in NS children was 4.56 (SD 0.23) mg/dLand 1.45 (SD 0.24) g/dL, respectively. Statistical difference between ionized calcium level in NS and in healthy children was significant (P<0.05). Pearson correlation test between ionized calcium and serum albumin was significant (P<0.05) with correlation coefficient (r) 0.53. We found the following equation to estimate ionized calcium (y) based on the serum albumin level (x): y=3.84+0.49x.Conclusion There is a moderately positive linear relationship between ionized calcium and serum albumin level in NS children.

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