Subclinical hypothyroidism in pediatric nephrotic syndrome: the correlations with albumin, globulin, and proteinuria

Background Nephrotic syndrome causes loss of medium-sized plasma proteins and binding proteins, resulting in thyroid hormone deficiency. Objective To assess for potential correlations between subclinical hypothyroidism in pediatric nephrotic syndrome with albumin, globulin, and proteinuria. Methods This cross-sectional study was conducted in the Department of Pediatrics, Hasan Sadikin General Hospital, Bandung, West Java. All types of nephrotic syndrome patients aged 1 month to < 18 years were included. Blood and urine specimens were collected from the patients for albumin, globulin, thyroid function (T3, fT4 and TSH), and proteinuria tests and analyzed with standard techniques. Results There were 26 subjects, 20 males and 6 females. Ten subjects developed subclinical hypothyroidism, with mean albumin and thyroid-stimulating hormone (TSH) levels of 0.92 g/dL and 6.9 mIU/L, respectively. There was a negative correlation between albumin level and subclinical hypothyroidism (rpb=-0.702; P<0.001) and a positive correlation between proteinuria and subclinical hypothyroidism (r=0.573; P=0.003). Univariate logistic regression analysis revealed that globulin had no impact on the presence of subclinical hypothyroidism, but albumin and proteinuria did have such an impact. The odds ratios of albumin and proteinuria with subclinical hypothyroidism were 27.00 (95%CI 1.69 to 17.7) and 19.80 (95%CI 1.94 to 201.63), respectively. Conclusion Subclinical hypothyroidism correlates with serum albumin level and proteinuria in nephrotic syndrome patients. Tha low serum albumin level has a high likelihood of subclinical hypothyroidism.

Download Full-text

Subclinical hypothyroidism in pediatric nephrotic syndrome: the correlations with albumin, globulin, and proteinuria

Paediatrica Indonesiana ◽

10.14238/pi60.2.2020.91-5 ◽

2020 ◽

Vol 60 (2) ◽

pp. 91-5

Author(s):

Erni Nuraeni ◽

Faiisal Faisal ◽

Ahmedz Widiasta ◽

Novina Novina

Keyword(s):

Nephrotic Syndrome ◽

Serum Albumin ◽

Subclinical Hypothyroidism ◽

Serum Albumin Level ◽

Cross Sectional Study ◽

Albumin Level ◽

Thyroid Stimulating Hormone ◽

Hormone Deficiency ◽

Cross Sectional ◽

Univariate Logistic Regression Analysis

Download Full-text

Serum Albumin Level as a Prognostic Marker for Covid-19 Positive Patients in Western Uttar Pradesh - A Cross Sectional Study

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/39 ◽

2021 ◽

Vol 8 (04) ◽

pp. 204-207

Author(s):

Shreyansh Talera ◽

Saurabh Singhal ◽

Nishant Wadhera ◽

Mayank Arora ◽

Ravi Pratap

Keyword(s):

Serum Albumin ◽

Prognostic Marker ◽

Serum Albumin Level ◽

Uttar Pradesh ◽

Cross Sectional Study ◽

Albumin Level ◽

The Body ◽

Cross Sectional ◽

Significant Difference

BACKGROUND WHO has declared Coronavirus disease 2019 (Covid-19) as a pandemic. Covid-19 leads to sickness and death. Human serum albumin (HSA) is the most common circulating protein in the body having oncotic as well as non-oncotic properties. The role of albumin in death among Covid-19 subjects, especially in this part of the country has not been frequently reported. The aim of the study was to analyse the role of serum albumin level as prognostic marker for Covid-19 positive patients. METHODS The present study was conducted in the department of Medicine at Chhatrapati Shivaji Subharti Hospital, Subharti Medical College, Meerut, UP. The study comprised of 100 subjects who were Covid positive from May 2020 to July 2020. A detailed explanation was given to all the participating respondents regarding the study and their contribution to it. Covid-19 was diagnosed on the basis of the WHO interim guidelines. A questionnaire was prepared to collect the patients’ demographic profile. Patients date of admission and discharge was recorded along with the outcome i.e., whether patient expired or survived. Patients’ diagnosis was identified along with the comorbidity (if present). Laboratory investigations comprised of CBC and serum albumin detection. Data so collected was tabulated in an excel sheet, under the guidance of statistician. Collected data was analysed using Statistical Package for the Social Sciences (SPSS) software version 24 and the tests used were t test and Fisher’s exact test and the level of significance was set at p < 0.05. RESULTS The study comprised of 100 subjects, out of which 45 were males and 55 were females. The overall mean age of the study subjects was 37.52 years. In our study, mortality was 35.29 %, 9.33 % and 85.7 % of the subjects having Covid-19+ type 2 diabetes (T2DM), only Covid-19 and Covid-19+ hypertension respectively with statistically significant difference as p < 0.05. Albumin level was significantly lower in expired patients (2.99) as compared to survivors (3.85) as p < 0.05. Hospital stay was also higher in expired patients. CONCLUSIONS Covid-19 patients had low serum albumin levels and that might play a role in the survival of patient. KEYWORDS Covid-19, Mortality, Albumin

Download Full-text

ANALISIS KADAR ALBUMIN SERUM DENGAN RASIO DE RITIS PADA PENDERITA HEPATITIS B

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v13i2.884 ◽

2018 ◽

Vol 13 (2) ◽

pp. 60

Author(s):

AT. Lopa ◽

B. Rusli ◽

M. Arif ◽

Hardjoeno Hardjoeno

Keyword(s):

Hepatitis B ◽

Serum Albumin ◽

Serum Albumin Level ◽

Chronic Phase ◽

Cross Sectional Study ◽

Albumin Level ◽

P Value ◽

Sectional Study ◽

Cross Sectional ◽

Significant Difference

Hepatitis is a inflammation process which may present in an acute or chronic phase. A decrease of serum albumin level may befound in liver disease. Ratio de Ritis in mild hepatitis is < 1 while in alcoholic hepatitis is >1. To analyze serum albumin level withratio de Ritis in hepatitis B patients. A cross sectional study was carried out comprising 46 subjects from October 2005 to August 2006measuring albumin level SGOT and SGPT levels using Lyasis autoanalyzer. Thirty eight males and eight females, the level of serumalbumin decreased with an average of albumin level 2.98 gr/dL (p<0.05). Twenty two subjects showed a ratio de Ritis ≤ 1 with theaverage albumin level 3.00 gr/dL and 24 subjects were included in group ratio de Ritis > 1 with average albumin level 2.96 gr/dL(p value = 0.658). There was a decrease of serum albumin level in hepatitis B patient but no significant difference between decrease ofserum albumin level with ratio of de Ritis ≤ 1 and ratio of de Ritis >1.

Download Full-text

Correlation of serum level of albumin with platelet count and platelet aggregation assessed by adenosine diphosphate agonist in children with nephrotic syndrome

Paediatrica Indonesiana ◽

10.14238/pi59.1.2019.7-12 ◽

2019 ◽

Vol 59 (1) ◽

pp. 7-12

Author(s):

Andar Laura Nainggolan ◽

Sri Sudarwati ◽

Dany Hilmanto

Keyword(s):

Nephrotic Syndrome ◽

Platelet Count ◽

Platelet Aggregation ◽

Serum Albumin ◽

Serum Albumin Level ◽

Pediatric Nephrology ◽

Correlation Coefficients ◽

Adenosine Diphosphate ◽

Albumin Level ◽

Cross Sectional

Background Nephrotic syndrome (NS) is the most common renal disease among children, and contributes to life-threatening complications such as thromboembolic disease. Platelets are considered to be important agents in thrombotic events among NS patients. The gold standard assessment for platelet aggregation is the use of adenosine diphosphate (ADP) agonist, however, it is expensive and not accessible in smaller health facilities. Thus, other thrombosis parameters are needed. Previous studies suggested that low albumin increased the risk of thrombosis in NS patients. Objective To assess for a possible correlation between albumin level and platelet count as well as platelet aggregation. Methods This cross-sectional study was conducted in children with nephrotic syndrome who were admitted to the Pediatric Nephrology Department in Dr. Hasan Sadikin General Hospital, Bandung, West Java, from November 2017 to March 2018. Subjects were selected by consecutive sampling. Serum albumin, platelet count, and platelet aggregation were measured. Statistical analysis was conducted by Spearman’s test. Results A total of 32 patients participated in the study, with mean age of 109 (SD 7.4) months. Most subjects were male (56%). Subjects’ mean serum albumin level was 2.06 (SD 1.23) g/dL; mean platelet count was 453,062.5 (SD 187,443.90)/mm3; and mean platelet aggregation values for ADP agonist concentrations of 10, 5, 2.5, and 1 mM were 86.8 (SD 8.63)%, 82.4 (SD 15.33)%, 66.6 (SD 24.90)%, 34.95 (SD 31.69)%, respectively. Partial correlation analysis revealed significant negative associations between albumin and platelet count as well as platelet aggregation assessed with 1 mM of ADP concentration (P<0.001), with Spearman correlation coefficients of -0.641 and -0.634, respectively. Conclusion Serum albumin level had a moderately negative correlation with platelet count and platelet aggregation value.

Download Full-text

Relationship between ionized calcium and serum albumin level in children with idiopathic nephrotic syndrome

Paediatrica Indonesiana ◽

10.14238/pi50.6.2010.361-4 ◽

2016 ◽

Vol 50 (6) ◽

pp. 361

Author(s):

Viiola Irene Winata ◽

Dida Akhmad Gurnida ◽

Nanan Sekarwana

Keyword(s):

Nephrotic Syndrome ◽

Serum Albumin ◽

Calcium Level ◽

Serum Albumin Level ◽

Pearson Correlation ◽

Health Department ◽

Albumin Level ◽

Ionized Calcium ◽

Healthy Children ◽

Cross Sectional

Background Nephrotic syndrome (NS) patients frequently have abnormalities in calcium metabolism that manifest as hypocalcemia and reduced intestinal absorption of calcium. Hypocalcemia is initially attributed to hypoalbuminemia but it may also relate to a low level of ionized calcium. The ionized calcium level depends on the severity and duration of proteinuria.Objective To assess the rel ationship between ionized calcium and serum albumin level in idiopathic NS children.Methods An analytical study with cross-sectional design was applied to NS and healthy children between 1-14 years old in the Child Health Department of Hasan Sadikin Hospital, Bandung from December 2009 to April 2010. Ionized calcium was examined by Ca2 + analyzer AVL 980 with ion-selective electrodes (ISE) methods.Results A total of34 subjects were recruited, consist of 17 NS and 17 healthy children. The mean ionized calcium and serum albumin level in NS children was 4.56 (SD 0.23) mg/dLand 1.45 (SD 0.24) g/dL, respectively. Statistical difference between ionized calcium level in NS and in healthy children was significant (P<0.05). Pearson correlation test between ionized calcium and serum albumin was significant (P<0.05) with correlation coefficient (r) 0.53. We found the following equation to estimate ionized calcium (y) based on the serum albumin level (x): y=3.84+0.49x.Conclusion There is a moderately positive linear relationship between ionized calcium and serum albumin level in NS children.

Download Full-text

Correlation between serum albumin and creatinine levels in children with nephrotic syndrome

Paediatrica Indonesiana ◽

10.14238/pi48.6.2008.354-7 ◽

2016 ◽

Vol 48 (6) ◽

pp. 354

Author(s):

Gartika Sapartini ◽

Dedi Rachmadi ◽

Herry Garna

Keyword(s):

Nephrotic Syndrome ◽

Serum Creatinine ◽

Serum Albumin ◽

Serum Creatinine Level ◽

Creatinine Level ◽

Pearson Correlation ◽

Renal Perfusion ◽

Cross Sectional Study ◽

Albumin Level ◽

Cross Sectional

Background Nephrotic syndrome is a glomerular disordercharacterized by massive proteinuria, hypoalbuminemia, edema,and hyperlipidemia. Hypoalbuminemia in nephrotic syndromeleads to hypovolemia, a decrease in renal perfusion and glomerularfiltration rate. Serum creatinine level reflects the glomerularfiltration rate.Objective The aim of this study was to determine the correlationbetween serum albumin and creatinine levels in children withnephrotic syndrome.Methods A cross-sectional study was carried out on children withidiopathic nephrotic syndrome, aged between 1 to 14 years old,admitted to Pediatric Department in Hasan Sadikin Hospitalfrom January 2001 to September 2007. We used data frompatients' medical records to obtain serum albumin and creatininelevels during nephrotic stage. Statistical analysis using Pearsoncorrelation test was performed to establish the correlation betweenserum albumin and creatinine levels. The type of correlation wasdetermined by regression analysis.Results Subjects were 113 children, consisted of 81 boys (72%)with mean of age 6.8 (SD 3.3) years. Mean of serum albumin andcreatinine levels were 1.4 (SD 0.4) g/dL and 0.7 (SD 0.4) mg/dL, respectively. Analysis using Pearson correlation test showeda moderate (r=-0.478) significant correlation (P<O.Ol) betweenserum albumin and creatinine levels in children with nephroticsyndrome. Regression analysis suggested a negative linearrelationship between serum albumin level as the independentvariable (X) and serum creatinine level as the dependent variable(Y) by using equation Y = 1.328-0.460X.Conclusion In patients with nephrotic syndrome there is amoderate negative correlation between serum albumin andcreatinine levels.

Download Full-text

Effect of the Cut-Off Level for Thyroid-Stimulating Hormone on the Prevalence of Subclinical Hypothyroidism among Infertile Mexican Women

Diagnostics ◽

10.3390/diagnostics11030417 ◽

2021 ◽

Vol 11 (3) ◽

pp. 417

Author(s):

Lidia Arce-Sánchez ◽

Salvatore Giovanni Vitale ◽

Claudia Montserrat Flores-Robles ◽

Myrna Souraye Godines-Enriquez ◽

Marco Noventa ◽

...

Keyword(s):

Insulin Resistance ◽

Subclinical Hypothyroidism ◽

Thyroid Autoimmunity ◽

Cross Sectional Study ◽

Thyroid Stimulating Hormone ◽

Mexican Women ◽

Cross Sectional ◽

Group 3 ◽

Group 2 ◽

Group 1

The primary aim of this study was to compare the prevalence of subclinical hypothyroidism (SCH) using two different cut-off levels for TSH values (≥2.5 mIU/L versus ≥4.1 mIU/L). The secondary objective was to analyze the clinical-biochemical characteristics in women with and without SCH. This was a retrospective cross-sectional study. In total, 1496 Mexican women with infertility were included: Group 1, women with TSH levels ranging between 0.3 and 2.49 mIU/L, n = 886; Group 2, women with TSH between 2.5 and 4.09 mIU/L, n = 390; and Group 3, women with TSH ≥4.1 mIU/L n = 220. SCH prevalence was 40.7% (CI 95%: 38.3–43.3%) with TSH cut-off ≥ 2.5 mIU/L, and 14.7% (CI 95%: 12.7–16.5%) with TSH cut-off ≥ 4.1 mIU/L, (p = 0.0001). The prevalence of overweight was higher in Group 2 than in Groups 1 and 3. Thyroid autoimmunity, obesity and insulin resistance were higher in Group 3 than in Group 1 (p < 0.05). No other differences were observed between groups. Conclusions: The prevalence of SCH in our selected patients increased almost three times using a TSH cut-off ≥ 2.5 mIU/L compared with a TSH cut-off ≥ 4.1 mIU/L. Women with TSH ≥4.1 mIU/L compared with TSH cut-off ≤ 2.5 mIU/L more often presented with obesity, thyroid autoimmunity and insulin resistance.

Download Full-text

Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndrome

Clinical and Experimental Nephrology ◽

10.1007/s10157-011-0578-y ◽

2011 ◽

Vol 16 (3) ◽

pp. 411-414 ◽

Cited By ~ 8

Author(s):

Kazunari Kaneko ◽

Takahisa Kimata ◽

Shoji Tsuji ◽

Tomohiko Shimo ◽

Masaya Takahashi ◽

...

Keyword(s):

Nephrotic Syndrome ◽

Serum Albumin ◽

Serum Albumin Level ◽

Idiopathic Nephrotic Syndrome ◽

Albumin Level

Download Full-text

Liver Biomarkers Assay in COVID-19 Cases: A Comparison Study between Alive and Dead Patients

Iranian Journal of Public Health ◽

10.18502/ijph.v51i1.8309 ◽

2022 ◽

Author(s):

Amir Emami ◽

Fatemeh Javanmardi ◽

Ali Akbari ◽

Babak Shirazi Yeganeh ◽

Tahereh Rezaei ◽

...

Keyword(s):

Serum Albumin Level ◽

Critical Role ◽

High Sensitivity ◽

Cross Sectional Study ◽

Albumin Level ◽

Hospital Death ◽

Comparison Study ◽

Sectional Study ◽

Laboratory Findings ◽

Cross Sectional

Background: Identifying effective biomarkers plays a critical role on screening; rapid diagnosis; proper managements and therapeutic options, which is helpful in preventing serious complications. The present study aimed to compare the liver laboratory tests between alive and dead hospitalized cases for prediction and proper management of the patients. Methods: This retrospective, cross sectional study consists of all deceased patients admitted in one center in Shiraz, Iran during 19 Feb 2020 to 22 Aug 2021. For further comparison, we selected a 1:2 ratios alive group randomly. Results: Overall, 875 hospitalized cases died due to COVID-19. We selected 1750 alive group randomly. The median age was significantly higher in died group (65.96 vs 51.20). Regarding the laboratory findings during the hospitalization ALT, AST, Bili.D were significantly higher in non-survivors than survivors but Albumin was less in deceased patients. It was revealed elevated levels of Albumin, AST, Bili.T and Bili.D were associated with increasing the risk of in hospital death. Moreover, the predictive effect of ALP and Bili.D had significantly more than others with high sensitivity and specify. Conclusion: We found patients with COVID-19 have reduced serum albumin level, and increase ALT and AST. The current results revealed abnormal liver chemistries is associated with poor outcome, which highlighted the importance of monitoring these patients more carefully and should be given more caution.

Download Full-text

Fibrinogen status in relapse and remission of childhood nephrotic syndrome

Paediatrica Indonesiana ◽

10.14238/pi46.4.2006.149-53 ◽

2016 ◽

Vol 46 (4) ◽

pp. 149

Author(s):

Veronica Lily Limantara ◽

Ida Bagus Mudita ◽

I Ketut Suarta

Keyword(s):

Nephrotic Syndrome ◽

Serum Albumin ◽

Cross Sectional Study ◽

Fibrinogen Concentration ◽

Strongly Correlated ◽

Sectional Study ◽

Laboratory Findings ◽

Cross Sectional ◽

Remission Status ◽

The Mean

Objective To evaluate fibrinogen concentration of relapsing neph-rotic syndrome (NS) in children, and to investigate relationshipbetween fibrinogen with albumin and cholesterol.Methods A cross-sectional study among NS patients admitted topediatric outpatient clinic and pediatric ward at Sanglah Hospital,Denpasar, from November 1, 2003 to January 31, 2004. All pa-tients were evaluated for clinical and laboratory findings of relapseand remission, including edema, proteinuria, serum albumin, totalcholesterol, as well as total platelet count and fibrinogen concen-tration to evaluate coagulation parameters in nephrotic patients.Results There were 36 patients with the mean age of 7.4 (SD 2.3)years included in this study. Mean fibrinogen concentration in re-lapse state was 671.8 (SD 102.7) mg/dl, while in remission statewas 255.2 (SD 50.5 mg/dl); the mean difference was 416.6 mg/dl(95% CI 362.9;470.4; P<0.001). Fibrinogen was inversely andstrongly correlated with serum albumin concentrations (r=-0.91;P<0.001). Fibrinogen was positively and strongly correlated to to-tal cholesterol (r=0.80; P<0.001). Using multiple regression analy-sis, it was shown that only relapse/remission status was signifi-cantly associated with fibrinogen concentration (P<0.001).Conclusion Fibrinogen status is significantly correlated with re-lapse and remission status of NS in childhood patients.

Download Full-text