Relationship between ionized calcium and serum albumin level in children with idiopathic nephrotic syndrome

Background Nephrotic syndrome (NS) patients frequently have abnormalities in calcium metabolism that manifest as hypocalcemia and reduced intestinal absorption of calcium. Hypocalcemia is initially attributed to hypoalbuminemia but it may also relate to a low level of ionized calcium. The ionized calcium level depends on the severity and duration of proteinuria.Objective To assess the rel ationship between ionized calcium and serum albumin level in idiopathic NS children.Methods An analytical study with cross-sectional design was applied to NS and healthy children between 1-14 years old in the Child Health Department of Hasan Sadikin Hospital, Bandung from December 2009 to April 2010. Ionized calcium was examined by Ca2 + analyzer AVL 980 with ion-selective electrodes (ISE) methods.Results A total of34 subjects were recruited, consist of 17 NS and 17 healthy children. The mean ionized calcium and serum albumin level in NS children was 4.56 (SD 0.23) mg/dLand 1.45 (SD 0.24) g/dL, respectively. Statistical difference between ionized calcium level in NS and in healthy children was significant (P<0.05). Pearson correlation test between ionized calcium and serum albumin was significant (P<0.05) with correlation coefficient (r) 0.53. We found the following equation to estimate ionized calcium (y) based on the serum albumin level (x): y=3.84+0.49x.Conclusion There is a moderately positive linear relationship between ionized calcium and serum albumin level in NS children.

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Correlation Between Serum Albumin Level and Ionized Calcium in Idiopathic Nephrotic Syndrome in Children

Urology & Nephrology Open Access Journal ◽

10.15406/unoaj.2016.03.00070 ◽

2016 ◽

Vol 3 (2) ◽

Cited By ~ 1

Author(s):

Azizul Hossain

Keyword(s):

Nephrotic Syndrome ◽

Serum Albumin ◽

Serum Albumin Level ◽

Idiopathic Nephrotic Syndrome ◽

Albumin Level ◽

Ionized Calcium

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Correlation of serum level of albumin with platelet count and platelet aggregation assessed by adenosine diphosphate agonist in children with nephrotic syndrome

Paediatrica Indonesiana ◽

10.14238/pi59.1.2019.7-12 ◽

2019 ◽

Vol 59 (1) ◽

pp. 7-12

Author(s):

Andar Laura Nainggolan ◽

Sri Sudarwati ◽

Dany Hilmanto

Keyword(s):

Nephrotic Syndrome ◽

Platelet Count ◽

Platelet Aggregation ◽

Serum Albumin ◽

Serum Albumin Level ◽

Pediatric Nephrology ◽

Correlation Coefficients ◽

Adenosine Diphosphate ◽

Albumin Level ◽

Cross Sectional

Background Nephrotic syndrome (NS) is the most common renal disease among children, and contributes to life-threatening complications such as thromboembolic disease. Platelets are considered to be important agents in thrombotic events among NS patients. The gold standard assessment for platelet aggregation is the use of adenosine diphosphate (ADP) agonist, however, it is expensive and not accessible in smaller health facilities. Thus, other thrombosis parameters are needed. Previous studies suggested that low albumin increased the risk of thrombosis in NS patients. Objective To assess for a possible correlation between albumin level and platelet count as well as platelet aggregation. Methods This cross-sectional study was conducted in children with nephrotic syndrome who were admitted to the Pediatric Nephrology Department in Dr. Hasan Sadikin General Hospital, Bandung, West Java, from November 2017 to March 2018. Subjects were selected by consecutive sampling. Serum albumin, platelet count, and platelet aggregation were measured. Statistical analysis was conducted by Spearman’s test. Results A total of 32 patients participated in the study, with mean age of 109 (SD 7.4) months. Most subjects were male (56%). Subjects’ mean serum albumin level was 2.06 (SD 1.23) g/dL; mean platelet count was 453,062.5 (SD 187,443.90)/mm3; and mean platelet aggregation values for ADP agonist concentrations of 10, 5, 2.5, and 1 mM were 86.8 (SD 8.63)%, 82.4 (SD 15.33)%, 66.6 (SD 24.90)%, 34.95 (SD 31.69)%, respectively. Partial correlation analysis revealed significant negative associations between albumin and platelet count as well as platelet aggregation assessed with 1 mM of ADP concentration (P<0.001), with Spearman correlation coefficients of -0.641 and -0.634, respectively. Conclusion Serum albumin level had a moderately negative correlation with platelet count and platelet aggregation value.

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Subclinical hypothyroidism in pediatric nephrotic syndrome: the correlations with albumin, globulin, and proteinuria

Paediatrica Indonesiana ◽

10.14238/pi60.2.2020.90-4 ◽

2020 ◽

Vol 60 (2) ◽

pp. 90-4

Author(s):

Erni Nuraeni ◽

Faiisal Faisal ◽

Ahmedz Widiasta ◽

Novina Novina

Keyword(s):

Nephrotic Syndrome ◽

Serum Albumin ◽

Subclinical Hypothyroidism ◽

Serum Albumin Level ◽

Cross Sectional Study ◽

Albumin Level ◽

Thyroid Stimulating Hormone ◽

Hormone Deficiency ◽

Cross Sectional ◽

Univariate Logistic Regression Analysis

Background Nephrotic syndrome causes loss of medium-sized plasma proteins and binding proteins, resulting in thyroid hormone deficiency. Objective To assess for potential correlations between subclinical hypothyroidism in pediatric nephrotic syndrome with albumin, globulin, and proteinuria. Methods This cross-sectional study was conducted in the Department of Pediatrics, Hasan Sadikin General Hospital, Bandung, West Java. All types of nephrotic syndrome patients aged 1 month to < 18 years were included. Blood and urine specimens were collected from the patients for albumin, globulin, thyroid function (T3, fT4 and TSH), and proteinuria tests and analyzed with standard techniques. Results There were 26 subjects, 20 males and 6 females. Ten subjects developed subclinical hypothyroidism, with mean albumin and thyroid-stimulating hormone (TSH) levels of 0.92 g/dL and 6.9 mIU/L, respectively. There was a negative correlation between albumin level and subclinical hypothyroidism (rpb=-0.702; P<0.001) and a positive correlation between proteinuria and subclinical hypothyroidism (r=0.573; P=0.003). Univariate logistic regression analysis revealed that globulin had no impact on the presence of subclinical hypothyroidism, but albumin and proteinuria did have such an impact. The odds ratios of albumin and proteinuria with subclinical hypothyroidism were 27.00 (95%CI 1.69 to 17.7) and 19.80 (95%CI 1.94 to 201.63), respectively. Conclusion Subclinical hypothyroidism correlates with serum albumin level and proteinuria in nephrotic syndrome patients. Tha low serum albumin level has a high likelihood of subclinical hypothyroidism.

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Subclinical hypothyroidism in pediatric nephrotic syndrome: the correlations with albumin, globulin, and proteinuria

Paediatrica Indonesiana ◽

10.14238/pi60.2.2020.91-5 ◽

2020 ◽

Vol 60 (2) ◽

pp. 91-5

Author(s):

Erni Nuraeni ◽

Faiisal Faisal ◽

Ahmedz Widiasta ◽

Novina Novina

Keyword(s):

Nephrotic Syndrome ◽

Serum Albumin ◽

Subclinical Hypothyroidism ◽

Serum Albumin Level ◽

Cross Sectional Study ◽

Albumin Level ◽

Thyroid Stimulating Hormone ◽

Hormone Deficiency ◽

Cross Sectional ◽

Univariate Logistic Regression Analysis

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Correlation between serum albumin and creatinine levels in children with nephrotic syndrome

Paediatrica Indonesiana ◽

10.14238/pi48.6.2008.354-7 ◽

2016 ◽

Vol 48 (6) ◽

pp. 354

Author(s):

Gartika Sapartini ◽

Dedi Rachmadi ◽

Herry Garna

Keyword(s):

Nephrotic Syndrome ◽

Serum Creatinine ◽

Serum Albumin ◽

Serum Creatinine Level ◽

Creatinine Level ◽

Pearson Correlation ◽

Renal Perfusion ◽

Cross Sectional Study ◽

Albumin Level ◽

Cross Sectional

Background Nephrotic syndrome is a glomerular disordercharacterized by massive proteinuria, hypoalbuminemia, edema,and hyperlipidemia. Hypoalbuminemia in nephrotic syndromeleads to hypovolemia, a decrease in renal perfusion and glomerularfiltration rate. Serum creatinine level reflects the glomerularfiltration rate.Objective The aim of this study was to determine the correlationbetween serum albumin and creatinine levels in children withnephrotic syndrome.Methods A cross-sectional study was carried out on children withidiopathic nephrotic syndrome, aged between 1 to 14 years old,admitted to Pediatric Department in Hasan Sadikin Hospitalfrom January 2001 to September 2007. We used data frompatients' medical records to obtain serum albumin and creatininelevels during nephrotic stage. Statistical analysis using Pearsoncorrelation test was performed to establish the correlation betweenserum albumin and creatinine levels. The type of correlation wasdetermined by regression analysis.Results Subjects were 113 children, consisted of 81 boys (72%)with mean of age 6.8 (SD 3.3) years. Mean of serum albumin andcreatinine levels were 1.4 (SD 0.4) g/dL and 0.7 (SD 0.4) mg/dL, respectively. Analysis using Pearson correlation test showeda moderate (r=-0.478) significant correlation (P<O.Ol) betweenserum albumin and creatinine levels in children with nephroticsyndrome. Regression analysis suggested a negative linearrelationship between serum albumin level as the independentvariable (X) and serum creatinine level as the dependent variable(Y) by using equation Y = 1.328-0.460X.Conclusion In patients with nephrotic syndrome there is amoderate negative correlation between serum albumin andcreatinine levels.

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Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndrome

Clinical and Experimental Nephrology ◽

10.1007/s10157-011-0578-y ◽

2011 ◽

Vol 16 (3) ◽

pp. 411-414 ◽

Cited By ~ 8

Author(s):

Kazunari Kaneko ◽

Takahisa Kimata ◽

Shoji Tsuji ◽

Tomohiko Shimo ◽

Masaya Takahashi ◽

...

Keyword(s):

Nephrotic Syndrome ◽

Serum Albumin ◽

Serum Albumin Level ◽

Idiopathic Nephrotic Syndrome ◽

Albumin Level

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SERUM MAGNESIUM LEVEL

The Professional Medical Journal ◽

10.29309/tpmj/2010.17.02.2382 ◽

2010 ◽

Vol 17 (02) ◽

pp. 279-285

Author(s):

SADIA ZAFAR ◽

HINA AYESHA ◽

ASGHAR BUTT ◽

Bushra Abdul Malik

Keyword(s):

Serum Albumin Level ◽

Serum Magnesium ◽

Simple Random Sampling ◽

Albumin Level ◽

Magnesium Level ◽

Healthy Children ◽

Persistent Diarrhea ◽

Serum Magnesium Level ◽

Cross Sectional ◽

Study Setting

Objectives: To evaluate serum magnesium level in children with 3rd degree malnutrition and to compare these values with healthy children. Study Design: Cross sectional comparative study. Setting and Duration: Pediatric Department of Allied Hospital Faisalabad from Oct. 2003 to Nov. 2004. Subjects: Cases: 60 children of age six month to five year having weight < 60% of that for age. Control: 60 healthy children of age six month to five year having weight > 80% of that for age. Methods: Both cases & controls were selected from indoor & outdoor through simple random sampling. Detailed history & examination was done and S/Mg level were measured by atomic absorption spectrophotometer. Data was analyzed with the help of SPSS by applying T test and was presented by frequency tables. Results: The cases showed decreased S/Mg level (1.11+/- 0.24 mg/dl) as compared to controls (2.01+/- 0.78mg/dl).S/Mg levels were also decreased in cases with height < 80 % of that for age (0.98+/-0.5mg/dl) as compared to controls having height > 90 % of that for age. S/Mg levels were markedly low in cases who had low albumin level (0.98+/- 0.05 mg/dl) and those children who presented with persistent diarrhea (0.96+/-0.12mg/dl) Conclusion: S/Mg levels were decreased in children with PEM as compared to those with age and sex matched control. This decrease in S/Mglevels was marked in those cases who had decrease serum albumin level and persistent diarrhea.

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Serum Albumin Level as a Prognostic Marker for Covid-19 Positive Patients in Western Uttar Pradesh - A Cross Sectional Study

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/39 ◽

2021 ◽

Vol 8 (04) ◽

pp. 204-207

Author(s):

Shreyansh Talera ◽

Saurabh Singhal ◽

Nishant Wadhera ◽

Mayank Arora ◽

Ravi Pratap

Keyword(s):

Serum Albumin ◽

Prognostic Marker ◽

Serum Albumin Level ◽

Uttar Pradesh ◽

Cross Sectional Study ◽

Albumin Level ◽

The Body ◽

Cross Sectional ◽

Significant Difference

BACKGROUND WHO has declared Coronavirus disease 2019 (Covid-19) as a pandemic. Covid-19 leads to sickness and death. Human serum albumin (HSA) is the most common circulating protein in the body having oncotic as well as non-oncotic properties. The role of albumin in death among Covid-19 subjects, especially in this part of the country has not been frequently reported. The aim of the study was to analyse the role of serum albumin level as prognostic marker for Covid-19 positive patients. METHODS The present study was conducted in the department of Medicine at Chhatrapati Shivaji Subharti Hospital, Subharti Medical College, Meerut, UP. The study comprised of 100 subjects who were Covid positive from May 2020 to July 2020. A detailed explanation was given to all the participating respondents regarding the study and their contribution to it. Covid-19 was diagnosed on the basis of the WHO interim guidelines. A questionnaire was prepared to collect the patients’ demographic profile. Patients date of admission and discharge was recorded along with the outcome i.e., whether patient expired or survived. Patients’ diagnosis was identified along with the comorbidity (if present). Laboratory investigations comprised of CBC and serum albumin detection. Data so collected was tabulated in an excel sheet, under the guidance of statistician. Collected data was analysed using Statistical Package for the Social Sciences (SPSS) software version 24 and the tests used were t test and Fisher’s exact test and the level of significance was set at p < 0.05. RESULTS The study comprised of 100 subjects, out of which 45 were males and 55 were females. The overall mean age of the study subjects was 37.52 years. In our study, mortality was 35.29 %, 9.33 % and 85.7 % of the subjects having Covid-19+ type 2 diabetes (T2DM), only Covid-19 and Covid-19+ hypertension respectively with statistically significant difference as p < 0.05. Albumin level was significantly lower in expired patients (2.99) as compared to survivors (3.85) as p < 0.05. Hospital stay was also higher in expired patients. CONCLUSIONS Covid-19 patients had low serum albumin levels and that might play a role in the survival of patient. KEYWORDS Covid-19, Mortality, Albumin

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ESOPHAGEAL VARICES;

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.03.3255 ◽

2019 ◽

Vol 26 (03) ◽

Author(s):

Nadia Ijaz ◽

Tazeen Nazar ◽

Bilal Aziz

Keyword(s):

Liver Cirrhosis ◽

Hepatitis B ◽

Serum Albumin ◽

Esophageal Varices ◽

Serum Albumin Level ◽

Significant Negative Correlation ◽

Albumin Level ◽

P Value ◽

Cross Sectional ◽

Grade Ii

Objectives: To determine the correlation between serum albumin levels and the grades of esophageal varices in patients of liver cirrhosis due to hepatitis B and C. Study Design: Cross-sectional descriptive study. Place and Duration of Study: Unit I, Department of Medicine, Allied Hospital, Faisalabad from 29th June, 2014 to 28th December, 2014. Methodology: 95 patients of either sex between 20-70 years of age, with the diagnosis of liver cirrhosis due to hepatitis B and C were selected using non - probability consecutive sampling. The presence of esophageal varices was confirmed by endoscopy. Results: Out of a total of 95 patients, 59 (62.11%) were between the age group of 20-50 years while 36 (37.89%) were between 51-70 years of age. Mean+SD was calculated as 48.37+11.75 years. Gender distribution showed that 51 (53.68%) patients were males and 44 (46.32%) were females. Correlation between serum albumin level and the grade of esophageal varices in patients of liver cirrhosis due to hepatitis B & C showed that out of 26 cases with serum albumin level <2.8, 10 had Grade I and 16 had Grade II while out of 69 cases with ≥2.8 serum albumin level, 40 had grade I and 29 had grade II EV. r value was recorded to be -0.697 whereas p-value was calculated as 0.000. Conclusion: There is a significant negative correlation between serum albumin level and grade of esophageal varices in patients of liver cirrhosis due to hepatitis B and C.

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Association Between Hypoalbuminemia, Degree of Proteinuria, and Lupus Nephritis Class: A Single-Center Cross-Sectional Biopsy Study

Nephro-Urology Monthly ◽

10.5812/numonthly.112883 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Ngoc Nguyen Thi ◽

Dien Tran Minh ◽

Huong Nguyen Thu ◽

Phuong Luong Thi ◽

Nam Thai Thien ◽

...

Keyword(s):

Lupus Nephritis ◽

Serum Albumin ◽

Renal Biopsy ◽

Serum Albumin Level ◽

Albumin Level ◽

Viet Nam ◽

Albumin Concentration ◽

Single Center ◽

Cross Sectional ◽

The Mean

Background: The current study intended to determine whether serum albumin level and urine protein/creatinine rate (uPCR) are appropriate predictors of severe lupus nephritis in childhood-onset SLE. Objectives: Following a cross-sectional single-center design, 85 LN children referred to the National Children Hospital, Ha Noi, Viet Nam, from 6/2019 to 6/2020 were recruited. Renal biopsy was performed for all participants. Methods: Following a cross-sectional single-center design, 85 LN children referred to the National Children Hospital, Ha Noi, Viet Nam, from 6/2019 to 6/2020 were recruited. Renal biopsy was performed for all participants. Results: The mean SLEDAI score of all patients was 14.69. The proportion of patients with high and very high SLEDAI was 61.2 and 17.6%, respectively. The mean concentration of serum albumin was 28.55 g/L, and the proportion of decreased albumin concentration was 55.3%. The median uPCR was 446.6 mg/mmol in which 76.5% of values were ≥ 200 mg/mmol. Pathological morphology of LN class from I to VI was observed in 0%, 17.6%, 37.6 %, 37.6%, 7.1%, and 0%, respectively. Serum albumin level and uPCR presented the predictive value for severe and active LN (class IV and V); (AUC: 0.725 P < 0.001 for both). Conclusions: Serum albumin and uPCR were appropriate predictors for severe and active LN in Vietnamese children.

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