Analysis of cytotoxic T lymphocytes and Fas/FasL in Japanese patients with non-small cell lung cancer associated with HLA-A2

2002 ◽  
Vol 128 (11) ◽  
pp. 581-588 ◽  
Author(s):  
Chie Yoshimura ◽  
Shosaku Nomura ◽  
Shigenori Kanazawa ◽  
Midori Kuwana ◽  
Mikiko Muramatsu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Lymphocytes ◽  
Small Cell Lung Cancer ◽  
Cytotoxic T Lymphocytes ◽  
Cell Lung Cancer ◽  
Japanese Patients ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Small cell lung cancer stem cells display mesenchymal properties and exploit immune checkpoint pathways in activated cytotoxic T lymphocytes

2021 ◽  
Author(s):  
M. Alper Kursunel ◽  
Ekim Z. Taskiran ◽  
Ece Tavukcuoglu ◽  
Hamdullah Yanik ◽  
Funda Demirag ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cells ◽  
T Lymphocytes ◽  
Small Cell Lung Cancer ◽  
Cytotoxic T Lymphocytes ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Tumor Type ◽  
Small Cell Lung ◽  
Ifn Γ

AbstractSmall cell lung cancer (SCLC) is an aggressive tumor type with early dissemination and distant metastasis capacity. Even though optimal chemotherapy responses are observed initially in many patients, therapy resistance is almost inevitable. Accordingly, SCLC has been regarded as an archetype for cancer stem cell (CSC) dynamics. To determine the immune-modulatory influence of CSC in SCLC, this study focused on the characterization of CD44+CD90+ CSC-like subpopulations in SCLC. These cells displayed mesenchymal properties, differentiated into different lineages and further contributed to CD8+ cytotoxic T lymphocytes (CTL) responses. The interaction between CD44+CD90+ CSC-like cells and T cells led to the upregulation of checkpoint molecules PD-1, CTLA-4, TIM-3, and LAG3. In the patient-derived lymph nodes, CD44+ SCLC metastases were also observed with T cells expressing PD-1, TIM-3, or LAG3. Proliferation and IFN-γ expression capacity of TIM-3 and LAG3 co-expressing CTLs are adversely affected over long-time co-culture with CD44+CD90+ CSC-like cells. Moreover, especially through IFN-γ secreted by the T cells, the CSC-like SCLC cells highly expressed PD-L1 and PD-L2. Upon a second encounter with immune-experienced, IFN-γ-stimulated CSC-like SCLC cells, both cytotoxic and proliferation capacities of T cells were hampered. In conclusion, our data provide evidence for the superior potential of the SCLC cells with stem-like and mesenchymal properties to gain immune regulatory capacities and cope with cytotoxic T cell responses. With their high metastatic and immune-modulatory assets, the CSC subpopulation in SCLC may serve as a preferential target for checkpoint blockade immunotherapy .

scholarly journals The Induction of Cytotoxic T Lymphocytes against HLA-A Locus-matched Lung Adenocarcinoma in Patients with Non-small Cell Lung Cancer

1997 ◽  
Vol 88 (8) ◽  
pp. 743-749 ◽  
Author(s):  
Ichiro Yoshino ◽  
Mitsuhiro Takenoyama ◽  
Hiroshi Fujie ◽  
Takeshi Hanagiri ◽  
Takashi Yoshimatsu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Lymphocytes ◽  
Lung Adenocarcinoma ◽  
Small Cell Lung Cancer ◽  
Cytotoxic T Lymphocytes ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

P-091 Targeting small cell lung cancer with virus-specific CD8+cytotoxic t lymphocytes

Lung Cancer ◽  
2005 ◽  
Vol 49 ◽  
pp. S137-S138
Author(s):  
A. Moss ◽  
F. Aladin ◽  
E. Marshal ◽  
N. Blake ◽  
J. Coulson
Keyword(s):  
Lung Cancer ◽  
T Lymphocytes ◽  
Small Cell Lung Cancer ◽  
Cytotoxic T Lymphocytes ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

Adjuvant vinorelbine and cisplatin after complete resection of stage II and III non-small cell lung cancer: long-term follow-up of our study of Japanese patients

Surgery Today ◽  
2018 ◽  
Vol 48 (7) ◽  
pp. 687-694 ◽  
Author(s):  
Makoto Sonobe ◽  
Masatsugu Hamaji ◽  
Hideki Motoyama ◽  
Toshi Menju ◽  
Akihiro Aoyama ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Japanese Patients ◽  
Complete Resection ◽  
Small Cell ◽  
Small Cell Lung ◽  
Long Term Follow Up

scholarly journals The coexpression of multi-immune inhibitory receptors on T lymphocytes in primary non-small-cell lung cancer

2017 ◽  
Vol Volume 11 ◽  
pp. 3367-3376 ◽  
Author(s):  
Wenjie Guo ◽  
Sihan Liu ◽  
Xiaoli Zhang ◽  
Yating Chen ◽  
Ruolan Qian ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Lymphocytes ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Inhibitory Receptors ◽  
Small Cell Lung

scholarly journals Retrospective analysis of Japanese patients with relapse or refractory small-cell lung cancer treated with amrubicin hydrochloride

2010 ◽  
Vol 1 (3) ◽  
pp. 569-572 ◽  
Author(s):  
YOUNG HAK KIM ◽  
TADASHI MIO ◽  
KATSUHIRO MASAGO ◽  
KAORU IRISA ◽  
YUICHI SAKAMORI ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Retrospective Analysis ◽  
Cell Lung Cancer ◽  
Japanese Patients ◽  
Small Cell ◽  
Small Cell Lung
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