Allelic loss of the short arm of chromosome 4 in neuroblastoma suggests a novel tumour suppressor gene locus

The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene.

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546 A potential second tumour suppressor gene locus located at chromosome 9p21 in non-small cell lung cancer

Lung Cancer ◽

10.1016/s0169-5002(97)89926-6 ◽

1997 ◽

Vol 18 ◽

pp. 140

Author(s):

Leeanne Mead ◽

Matthew Gillespie ◽

Kathleen Rayeroux ◽

Usha Rane ◽

Lou Irving ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Gene Locus ◽

Suppressor Gene ◽

Tumour Suppressor Gene ◽

Small Cell ◽

Tumour Suppressor ◽

Small Cell Lung ◽

Chromosome 9P21

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Refinement of an ovarian cancer tumour suppressor gene locus on chromosome arm 22q and mutation analysis ofCYP2D6,SREBP2 andNAGA

International Journal of Cancer ◽

10.1002/1097-0215(20000915)87:6<798::aid-ijc6>3.0.co;2-x ◽

2000 ◽

Vol 87 (6) ◽

pp. 798-802 ◽

Cited By ~ 9

Author(s):

Emma J. Bryan ◽

Nicola A. Thomas ◽

Karan Palmer ◽

Elisabeth Dawson ◽

Patricia Englefield ◽

...

Keyword(s):

Ovarian Cancer ◽

Mutation Analysis ◽

Gene Locus ◽

Suppressor Gene ◽

Tumour Suppressor Gene ◽

Tumour Suppressor ◽

Chromosome Arm

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Loss of heterozygosity on chromosome 5q in ovarian cancer is frequently accompanied by TP53 mutation and identifies a tumour suppressor gene locus at 5q13.1-21

British Journal of Cancer ◽

10.1038/bjc.1996.324 ◽

1996 ◽

Vol 74 (1) ◽

pp. 115-119 ◽

Cited By ~ 30

Author(s):

M Tavassoli ◽

H Steingrimsdottir ◽

E Pierce ◽

X Jiang ◽

M Alagoz ◽

...

Keyword(s):

Ovarian Cancer ◽

Loss Of Heterozygosity ◽

Gene Locus ◽

Tp53 Mutation ◽

Suppressor Gene ◽

Tumour Suppressor Gene ◽

Tumour Suppressor ◽

Chromosome 5Q

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Evidence for a new tumour suppressor gene locus for γ-radiation-induced thymic lymphoma located on the proximal part of mouse chromosome 18

Clinical & Translational Oncology ◽

10.1007/bf02710034 ◽

2004 ◽

Vol 6 (2) ◽

pp. 90-93 ◽

Cited By ~ 1

Author(s):

María Matabuena de Yzaguirre ◽

Javier Santos Hernández ◽

José Fernández Piqueras

Keyword(s):

Mouse Chromosome ◽

Gene Locus ◽

Proximal Part ◽

Suppressor Gene ◽

Tumour Suppressor Gene ◽

Tumour Suppressor ◽

Chromosome 18 ◽

Γ Radiation ◽

Thymic Lymphoma ◽

Radiation Induced

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The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update

The Scientific World JOURNAL ◽

10.1100/tsw.2006.268 ◽

2006 ◽

Vol 6 ◽

pp. 1705-1712 ◽

Cited By ~ 14

Author(s):

Mirna M Maarabouni ◽

Gwyn T Williams

Keyword(s):

Gene Locus ◽

Human Cancer ◽

Suppressor Gene ◽

Tumour Suppressor Gene ◽

Tumour Suppressor ◽

Suppressor Activity ◽

Major Significance ◽

Tumour Suppressor Activity ◽

Alternatively Spliced ◽

Candidate Tumour Suppressor

The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene.

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