RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?

The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene.

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The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update

The Scientific World JOURNAL ◽

10.1100/tsw.2006.268 ◽

2006 ◽

Vol 6 ◽

pp. 1705-1712 ◽

Cited By ~ 14

Author(s):

Mirna M Maarabouni ◽

Gwyn T Williams

Keyword(s):

Gene Locus ◽

Human Cancer ◽

Suppressor Gene ◽

Tumour Suppressor Gene ◽

Tumour Suppressor ◽

Suppressor Activity ◽

Major Significance ◽

Tumour Suppressor Activity ◽

Alternatively Spliced ◽

Candidate Tumour Suppressor

The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene.

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PTEN: A molecular target for neurodegenerative disorders

Translational Neuroscience ◽

10.2478/s13380-012-0018-9 ◽

2012 ◽

Vol 3 (2) ◽

Cited By ~ 6

Author(s):

Azza Ismail ◽

Ke Ning ◽

Abdulmonem Al-Hayani ◽

Basil Sharrack ◽

Mimoun Azzouz

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Neurodegenerative Disorders ◽

Neuronal Development ◽

Suppressor Gene ◽

Tumour Suppressor Gene ◽

Tumour Suppressor ◽

Suppressor Activity ◽

Tumour Suppressor Activity ◽

The Central Nervous System

AbstractPTEN (phosphatase and tensin homologue deleted in chromosome 10) was first identified as a candidate tumour suppressor gene located on chromosome 10q23. It is considered as one of the most frequently mutated genes in human malignancies. Emerging evidence shows that the biological function of PTEN extends beyond its tumour suppressor activity. In the central nervous system PTEN is a crucial regulator of neuronal development, neuronal survival, axonal regeneration and synaptic plasticity. Furthermore, PTEN has been linked to the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. Recently increased attention has been focused on PTEN as a potential target for the treatment of brain injury and neurodegeneration. In this review we discuss the essential functions of PTEN in the central nervous system and its involvement in neurodegeneration.

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